Myelofibrosis associated with IgG myeloma.
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Biomedical subjects
Publications and source records attributed to M Carlesimo.
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The authors present the results of a study carried on 25 cases (Hodgkin patients) performing before and after standardized radiotherapy on retroperitoneal lymph nodes (45 Gy): - radionephrography and determination of renal plasmatic flux and glomerular filtration; - liver scintigraphy by colloids and 99Tcm-HIDA and liver functional tests by 131I-Bengal rose; - pancreas scintigraphy. Focal damage of the hepatic left lobe in younger patients and transitory impairment of some renal functional tests have been observed.
To investigate whether highly active antiretroviral therapy (HAART) could improve CD28 molecule expression and CD28-costimulation pathway function we tested the effect of CD28-costimulation on T cell receptor/CD3 induced proliferative responses in a group of HIV-1-infected subjects with CD4+ cells>200/mmc before and after HAART. CD3-mediated responses are recovered or improved after HAART. However the ability of potentiating the responses through CD28-costimulation seemed conserved before therapy and decreased in parallel with increase of response to CD3 alone. These results confirm the integrity of CD28-pathway of costimulation in patients with CD4+ cells>200/mmc and suggest an inverse correlation between magnitude of response to CD3 alone and increase of CD3 response due to anti-CD28 addition.
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The clinical radiological and anatomohistological features of fourteen cases of epiphyseal chondroblastoma are described. The seat, origin, and evolution of the tumor are discussed. The diagnosis of the epiphyseal localization is easy, but there are same problems in the differential diagnosis of the epiphyseal-metaphyseal of metaphyseal forms.
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