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Biomedical subjects

M Carter

Publications and source records attributed to M Carter.

At least 127 records · Page 7Linked to original sources
PubMed1983

Neonatal pyruvate carboxylase deficiency with renal tubular acidosis and cystinuria.

This report concerns a patient with severe congenital lacticacidosis associated with proximal renal tubular acidosis and cystinuria. Enzyme studies with cultured skin fibroblasts obtained from the patient revealed zero pyruvate carboxylase activity, but propionyl-CoA carboxylase activity was normal. Administration of various vitamins in large amounts did not improve the clinical condition. In contrast, the patient began to thrive when her diet was supplemented with aspartic acid, asparagine, glutamic acid, and glutamine. The particular dietary treatment used and the biochemical findings merit consideration for management of future cases.

Acidosis↗
PubMed1982

Treatment of hyperargininaemia due to arginase deficiency with a chemically defined diet.

A brother and sister aged 11 and 17 years have been reported previously to have hyperargininaemia and arginase deficiency: they were treated with a semi-synthetic diet consisting of fat, carbohydrate, minerals, vitamins and essential amino acids in amounts equivalent to 0.55-0.65 g protein kg-1 day-1 for 2 years. Plasma arginine levels fell from 0.50-0.90 mumol/1 to 0.13-0.30 mumol/1 (normal range 0.02-0.15). Increased concentrations of arginine in the cerebrospinal fluid (CSF) fell from 0.069-0.098 mumol/l to 0.040-0.056 mumol/l (normal mean +/- SD = 0.020 +/- 0.006). Dibasic aminoaciduria returned to normal within 1 week. Substitution of the keto-acid analogues of five essential amino acids in the formula lowered arginine concentrations further, but proved to be unpalatable. Urinary concentrations of orotic acid, uridine and uracil fell toward normal but remained increased, even when the plasma ammonia concentration was measured as normal. Both patients showed a stable clinical improvement.

Adolescent↗
PubMed1981

Ultrasound of the prostate. Analysis of tissue texture and abnormalities.

Thirty-nine patients with benign prostatic hypertrophy, prostatic carcinoma, or prostatitis underwent ultrasonography using a transabdominal suprapubic approach. In both benign hypertrophy and prostatitis, the gland was enlarged and exhibited a homogeneous echo pattern, being hypoechoic in prostatitis and either hypo- or hyperechoic in hypertrophy. Carcinoma was characterized by focal areas of increased or decreased echogenicity with irregular margins. The various sonographic appearances are explained by correlation with the histological findings, and the advantages of the transabdominal approach are discussed. The authors suggest that widespread application of this technique will improve early detection of prostatic carcinoma.

Adenocarcinoma↗
PubMed1980

Beginnings of the New York State Mental Hygiene Medical Review Board 1976-1980.

A review is provided of the organization and functions of the New York State Mental Hygiene Medical Review Board and the first 4 years of its investigative activities into sudden, unexpected, mysterious, or unnatural deaths among mental patients. In 4 years 384 such deaths have been investigated, among which natural causes, suicide, and accidents are the most common. Certain medical procedures, laws, and administrative methods have been changed due to findings of the Board.

Airway Obstruction↗
PubMed1979

Excretion and synthesis of basement membrane disaccharide units in Masugi nephritis.

During nephrotoxic nephritis in the rat, an increased urinary excretion of glucosyl-galactosyl hydroxylysine and of galactosyl-hydroxylysine has been observed in the autologous phase of the disease. This due mainly to an elevation of the polypeptide-bound fraction of these hydroxylysyl glucosides with a molecular weight over 1,000 daltons. The levels of both urinary hydroxylysyl glucosides were correlated with proteinuria. Their increased excretion appears to originate in the lysed glomerular basement membrane. At the same stage of nephrotoxic nephritis, an increased glucosyl transferase activity could be demonstrated in the isolated glomeruli, correlated with albuminuria, attesting a higher turn-over of the disaccharide units of the glomerular basement membrane.

Albuminuria↗
PubMed1978

Unusual presentation of genital tuberculosis.

We report two cases of unusual presentation of genital tuberculosis. One patient had an enlarging perineal mass as the only clinical evidence of genitourinary tract involvement. The second had a testicular mass difficult to distinguish clinically from testicular tumor. There was no evidence of upper tract disease.

Adult↗
PubMed1974

A new avian influenza virus from feral birds in the USSR: recombination in nature?

Six avian influenza A viruses isolated in the USSR were characterized antigenically by using specific antisera to the isolated surface subunits of the known reference strains. Three of the viruses, all isolated from the same region, were characterized as A/duck/Ukraine/63 (Hav7 Neq2), and a virus isolated from a crow was of the Hong Kong/68 (H3 N2) type. The remaining two viruses were novel in that they possessed Hav7 Nav2 antigens, a combination that has not previously been reported. It is suggested that these new influenza viruses might have arisen by recombination in nature between the A/duck/Ukraine/63 (Hav7 Neq2) and A/tern/So. Africa/61 (Hav5 Nav2) strains of avian influenza viruses.

Animals↗