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Biomedical subjects

M Cassese

Publications and source records attributed to M Cassese.

26 records · Page 2Linked to original sources
PubMedDate not supplied

[A familial strain of amelogenesis imperfecta hypoplastic type with dominant x-linked heredity].

Hypoplastic amelogenesis imperfecta in members of four generations of a Campanian family is described. The females were affected to a lesser degree. A dominant X-linked mutation was apparently involved. The different forms of amelogenesis imperfecta are described in the light of their anatomical, clinical and radiological pictures and their transmission modalities. Suitable corrective treatment is required to offset the damage to masticatory function, and associated psychological and emotional consequences, especially in female subjects.

Adult↗
PubMedDate not supplied

[Weaning in cardiopulmonary bypass patients with compromised cardiac function. Comparison of enoximone and dopamine].

OBJECTIVE: Evaluate the effects of enoximone and dopamine in patients with impaired left ventricular function after cardiopulmonary bypass (CPB). DESIGN: Prospective study on a consecutive series of patients subdivided into two groups: enoximone (Group E) and dopamine (Group D). SETTING: Policlinico Umberto I, University La Sapienza of Rome. PATIENTS AND METHODS: Thirty patients undergoing elective myocardial revascularization. Before weaning from CPB the patients received inotropic drugs as follows: Group E: enoximone: bolus: 1 mg/kg in 10 min, and continuous infusion of 5 mcg/kg/min; Gruppo D: dopamine: continuous infusion of 5 mcg/kg/min. Hemodynamic measurements were made using a Swan-Ganz catheter inserted before the induction of anaesthesia. RESULTS: Enoximone has proved to be effective in decreasing pre-load and after-load of both right and left ventricle by a positive lusitropic effect and a reduction of systolic stress, thereby increasing the cardiac index. In group D patients maintenance of cardiac output has been demonstrated to be dependent on a chronotropic effect. As a consequence in group D the increase in rate-pressure product has reached potentially dangerous values, reflecting a marked increase in myocardial oxygen consumption. On the contrary in Group E the increase in rate-pressure product has been much more limited. Finally both drugs have proven effective, since all patients have been easily weaned from CPB. CONCLUSIONS: Enoximone is a useful and easily-handled drug to facilitate weaning from CPB of patients with preoperative impaired ventricular function.

Assisted Circulation↗