PubMed Health⌕ Search

Biomedical subjects

M Castellani

Publications and source records attributed to M Castellani.

36 records · Page 2Linked to original sources
PubMed1993

Fourier amplitude image circumferential profile analysis in the evaluation of the dipyridamole test.

The aim of this study was to evaluate a circumferential profile method of analysis (CPA) of the Fourier image of amplitude (FA), obtained by equilibrium gated radionuclide angiocardiography (EGRA) in the assessment of the response to the dipyridamole (DIP) test in patients with previous myocardial infarction. The changes in regional wall motion (RWM) induced by DIP in a group of 29 patients with previous MI were compared with those of a ten-patient control group. On the basis of SPECT thallium-201 standard stress-rest scintigraphy the infarcted patients were divided into 9 patients with fixed perfusion defects at four hours and 20 patients with both fixed and reversible perfusion defects. The quantitative CPA was carried out on the FA image normalized by the mean amplitude calculated for the left ventricle (LV) area. A circular ROI was drawn around the FA left ventricle image and two curves (basal and post-DIP) with 60 points were obtained. We compared this method with a five-sector method of analysis applied to the same FA images. An increase of 2 or more SD in the basal post-DIP ratio curve, compared with the average of the ratios in the control group, was found in 16 of 20 patients with reversible perfusion defects (sensitivity: 80%) and an increase in the same ratio was found in 2 of 9 MI patients with fixed perfusion defects (specificity: 78%). A sensitivity and specificity of 60% and 78% respectively were found using sectorial analysis.

Adult↗
PubMed1993

Thallium-201 lung uptake: comparison of an automatic and a manual method of ROI drawing.

An automatic method for ROI drawing to measure 201TI lung uptake after stress testing in planar and tomographic myocardial perfusion imaging, was compared with the more commonly used manual method. A linear correlation in the lung/heart ratio (LHR) and lung washout (LWO) data, obtained in planar and SPECT images with the two methods, was found. Pearson's correlation coefficient between the automatic and manual methods was highly significant both for LHR and for LWO. For LHR we found a high linear correlation between the two methods in the planar anterior (r = 0.71, p < 0.001), SPECT anterior (r = 0.84, p < 0.001), and SPECT LAO (r = 0.96, p < 0.001) views. The analysis of LWO data showed a good linear correlation for the planar anterior (r = 0.84, p < 0.001), SPECT anterior (r = 0.66, p < 0.005) and SPECT LAO (r = 0.79, p < 0.001) views. Furthermore, comparison by the student's t test of the averages of the LHR and LWO values obtained in the same views but with different methods was performed. The advantages and the critical issues associated with the automatic method are discussed; it appears to be quick and easy to perform and to be equivalent to the more time-consuming method based on a manual definition of left lung ROI.

Adult↗
PubMed1993

[Mammographic screening of the health district 38, hospital of Gardone Val Trompia (Brescia - Lombardy). Results of the first 2 rounds].

The authors report the results of the first two rounds of a mammographic screening program by the Health District of Gardone Val Trompia (Brescia) including women 50 to 69 years old. 9,650 women were invited for round one and 6,415 (66.5%) attended; 9,656 were invited for round two and 6,552 (67.8%) attended. Fifty-four cancers were found in round one (detection rate: 8.4/1000): 11.1% of them were in situ carcinomas, 63% were T1 and 24.1% were T2 lesions, or higher. In round two, 32 lesions were detected (detection rate: 4.9/1000): 15.6% of them were in situ carcinomas, 78.1% were T1 and 3.2% were T2 lesions. In the positive cases axillary lymph nodes involvement was observed in 24.1% of cases in round one and was unknown in 27.8%, but the figures decreased to 6.2% and 9.4%, respectively, in round two. Effectiveness indicators were always observed.

Aged↗
PubMed1993

Delayed effect of streptokinase on left ventricular function after acute myocardial infarction assessed by equilibrium gated radionuclide angiocardiography.

A blind comparative study was conducted on 80 consecutive patients who were given Streptokinase (SK) or placebo between 3 and 6 hours after the onset of acute myocardial infarction (AMI). Left ventricular ejection fraction (LVEF), peak ejection rate (PER), peak filling rate (PFR) and regional wall motion (RWM) were evaluated by equilibrium gated radionuclide angiocardiography (EGRA) at 3-5 weeks and 6 months after the onset of AMI. In the anterior AMI SK-group, the mean LVEF values rose from 0.37 at one month to 0.43 at six months, PER (end-diastolic volumes per second) from 1.76 to 2.00, and PFR (end-diastolic volumes per second) from 1.46 to 1.75 (p = 0.01, p < 0.05, and p < 0.05, respectively). In the anterior non-SK group no improvement was seen in any of the LV function parameters. Only a slight improvement was observed in the inferior AMI group, with no significant difference between the treated and non-treated patients. The regional wall motion analysis was in agreement with the global function data. In conclusion, SK treatment given between three and six hours after the onset of anterior AMI may result in some improvement in LV function, which becomes fully appreciable only after the complete resolution of stunning, i.e. after more than one month.

Aged↗
PubMed1993

[Decisive scintigraphic diagnosis in a case of Borrelia infective sacro-iliitis].

The authors describe one case of infections sacro-iliitis caused by Borrelia, where the diagnostic procedures by conventional radiology, computerized tomography and nuclear magnetic resonance imaging have not permitted the localization and the assessment of joint inflammatory disease. The bone "theree phases" scintiscan by 99m Technectium-methylene diphosphonate (99mTC-MDP) has made it possible to localize on left sacro-iliac synchondrosis a modification of radioactivity, due to inflammations. Next microbiological studies gave a positive result for borrelia. The authors finish by underlying the importance of the nuclear medicine methods in the screening of infective osteo-arthritis.

Adult↗
PubMed1980

[Breast metastasis as the initial clinical symptom of renal adenocarcinoma].

Renal adenocarcinoma shows an unpredictable clinical course. At autopsy, metastases are present in as many as 95 percent of patients with renal adenocarcinoma. The percentage of metastases from renal adenocarcinoma is greater than would be expected from the frequency of this carcinoma among all carcinomas. The breast is an exceptional site of metastasis, that is not described in literature. In the present report the metastasis in the breast represented the early symptom of renal adenocarcinoma.

Adenocarcinoma↗
PubMedDate not supplied

Non-invasive assessment of pulmonary artery involvement in Takayasu's arteritis.

OBJECTIVE: To evaluate pulmonary involvement in Italian patients with Takayasu's arteritis (TA). METHODS: A prospective analysis of 15 Italian patients with TA was carried out, including evaluation by perfusion and ventilation lung scintigraphy (planar and tomographic), standard chest X-ray, spirography and color-doppler echocardiography. All the patients were free of respiratory symptoms when examined. RESULTS: In all patients standard chest X-rays and ventilation scintigraphies were normal. 9/15 patients showed unmatched segmental perfusion defects (41 by planar evaluation vs. 48 by SPET). The number of defects was greater in the right lung than in the left (26 vs 18), with a higher frequency of moderate or large defects. Thirteen patients underwent spirography, which proved to be abnormal in 5 cases. Two of these patients were also positive on scintigraphy. No patient showed alterations attributable to TA on color-doppler echocardiography, except for 3 patients with mild to moderate aortic valve regurgitation. CONCLUSIONS: Our results show that vascular pulmonary involvement is frequent in TA (60% of cases) even in the absence of clinical signs. The planar image, simpler than the SPET to acquire, was sufficient to make an accurate diagnosis. Italian patients seem to show a pattern of extrapulmonary and pulmonary vascular involvement very similar to that reported in Japanese subjects, and different from that observed in other ethnic groups.

Adolescent↗