Biomedical subjects
Publications and source records attributed to M Ceccaldi.
Cases of Weismann-Netter and Stuhl disease reported in the literature usually involve stereotyped pictures characterized by the presence of tibio-fibular dysmorphism, most often the only abnormality. The authors present a current review of the literature on the basis of a new case of this tibio-fibular diaphyseal toxopachyosteosis.
The total body water can be assayed by the measurement of the diffusion space of heavy water. A well reproducible and inexpensive method is the infrared spectrometry, using two differential comparisons.
The authors investigated 100 patients (55 males and 45 females) aged 16 to 45 years who experienced cerebral ischemic attack, excluding venous thrombosis. Transient ischemic attacks accounted for 12% only. Attacks were related to usual causes of brain ischemia in 49 cases (premature atherosclerosis in 26, cardiopathy in 20 and lacunar stroke in 3). Thirty-eight events were attributed to most uncommon etiologies. Nonatherosclerotic arteriopathies (10 cases) such as spontaneous dissection, dysplasia or megadolichoarteries were easily diagnosed by angiography. Oral contraceptives (14 cases) and migraine (2 cases) were diagnosis of exclusion. Hematological disorders were a possible cause in 10 patients. Etiology remained undetermined in 13 cases. Four patients died acutely. Follow-up data were obtained in 93 survivors with a mean duration of 26 months (range, 6 to 60 months). Four subjects died during follow-up and 6 experienced recurrent stroke (annual recurrence rate: 3%). In activities of daily living, 64% of patients had complete autonomy while 13% had mild residual disability and 23% had severe handicap.
A 40-year-old man presented with both paraparesia and an athymhormic syndrome. Bicapsular lesions together with abnormal evoked motor potentials suggested cortical and spinal involvement in the deficiency syndrome. The neuropsychologic symptoms appeared to be secondary to bilateral pallidium lesions. Associated signs were adrenoleukocystrophy and adrenomyeloneuropathy suggesting the term, adrenoleukocyeloneuropathy.
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Disturbances of visual function can be the first symptom of Alzheimer disease (AD). Several cases of pathologically proven AD associated with Balint's syndrome have been reported, and, in most of them, an unusual occipito-parietal predominance of neurofibrillary tangles (NFT) and neuritic plaques (NP) was found. Systematic assessment of visual functions in groups of patients presenting with dementia of Alzheimer type (DAT) have shown deficits in several tests, especially in stereo-acuity, in motion sensitivity, in contrast sensitivity for low spatial frequencies and in backward masking sensitivity. In electrophysiological studies, abnormalities of flash visual evoked potentials, contrasting with preservation of pattern visual evoked potentials, have been repeatedly reported. Moreover, decreased glucose metabolism in visual association cortex and in partietal cortex is frequent in DAT. Quantitative studies of regional distribution of NFT and NP in AD indicate constant involvement of associative visual cortex and preservation of primary visual cortex. All these findings, taken together, suggest that the occipito-parietal cortex which constitutes the dorsal visual system and subtends visuo-spatial functions, is selectively affected in AD.