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Biomedical subjects

M Cerf

Publications and source records attributed to M Cerf.

At least 73 records · Page 4Linked to original sources
PubMed1979

[11C]methionine pancreatic scanning with positron emission computed tomography.

By the use of [11C]methionine and positron computed tomography (PCT), images of the pancreas were obtained in 32 patients. The injection of between 10 and 20 mCi of this product enables four to six transverse sections to be obtained. Seventeen of the patients studied had no exocrine pancreatic disease, and in all these cases the pancreas was clearly visible. In four cases of pancreatic carcinoma and one of retroperitoneal tumor, there were abnormalities visible. In five cases of chronic pancreatitis, no pancreatic uptake was observed. In a sixth case, concentration was visible, but only in the head of the pancreas. One case of acute pancreatitis, which showed no concentration during the acute phase, returned to normal after recovery. When visible, the pancreas was easily located and distinguishable from the intestinal image, except in two cases that were uninterpretable for technical reasons. No false positive or negative was observed, but a differential diagnosis between cancer and pancreatitis was impossible.

Carbon Radioisotopes↗
PubMed1978

[Postoperative medical icterus].

The onset of jaundice following a surgical operation sometimes raises difficult problems. It is rarely due to hemolysis, infective hepatitis or decomposated cirrhosis of the liver. One should seek as a routine hepatitis due to halotane. However the most frequent cause is "benign postoperative cholestasis". This variety of jaundice presents in the form of an icterus due to conjugated bilirubine with often a large increase in alkaline phosphatase levels. The ocurse is variable. Almost always due to severe surgical or septic trauma, accompanied by shock and/or anoxia, it raises difficult diagnostic problems. The clinical and physiopathological aspects of benign postoperative cholestasis are recalled. One should remember, above all, that this is not an autonomous clinical entity but the sign of local or general complications which should be sought carefully.

Alkaline Phosphatase↗
PubMed1977

[Impact of immune disorders in digestive pathology].

The digestive tract has a special immune system where predominate the secretory factors of IgA. The IgA secreted by the plasma cells of the digestive mucosa is dimeric and is poured into the intestinal lumen after being attached to a protein of epithelial orgin. These facts lead to defence reactions of a special type. The digestive consequences of a quantitative abnormality of this system (hypogammaglobulinemia) or qualitative abnormality such as alpha heavy chain disease or Whipple's disease, are briefly reviewed. The consequences of an abnormal response of this system are considered in the light of present knowledge concerning coeliac disease. On the whole, these recent studies should lead to a revision of the idea of digestive allergy.

Agammaglobulinemia↗
PubMed1977

Quantitative studies in vitro on uptake and esterification of palmitate into human and rat jejunal mucosa.

Quantitative incorporation and esterification of (9-10) 3H palmitate into jejunal mucosa was studied in vitro comparatively on human biopsies and on everted rings of rat intestine following various incubation times. This procedure is fitted for investigation of the glycophosphate pathway. Quantitatively the total uptake of palmitate was similar in man and rat. But the distribution among the various esterified fractions was different in animal and man and different again in coeliac disease. Notwithstanding incorporation of palmitate into triglyceride the fatty acid composition of mucosal triglyceride showed little or no modification.

Animals↗
PubMed1975

[Encapsulating peri-hepatitis. Apropos of 4 cases].

The authors report 4 cases of encapsulating peri-hepatitis, including an angiographic study. Selective arteriography of the coeliac trunk showed extremely sinuous intra-hepatic arteries in 3 of these cases, and obstruction of the portal vein, in one case. Catheterisation of the hepatic veins showed a pressure gradient between the obstructed hepatic vein and the free supra-hepatic pressure, showing a post-sinusoidal block. In 2 of the 4 cases, ascites was chylous. Lymphography carried out via lymphatics in the foot was negative in 3 cases where it was carried out. One case showed, on two successive laparoscopies, that micro-nodular cirrhosis was present before the development of encapsulating peri-hepatitis.

Adult↗
PubMed1975

[Effect of autotransplantation on various functions of the small intestine in swine].

The effects of anoxia on orthotopic small bowel autotransplantation were studied in 22 pigs respectively on the operative day (before and after transplantation) and post-operatively (on the 1st, 3d, 5th, 7th and 15th day). Absorption of D-xylose (as evaluated by xylosemia curve) and several brush border enzyme activities were compared with histological and histoenzymological data. After transplantation D-xylose test, enzymatic assays and to a lesser degree histoenzymology showed some impairment until the 15th day. By contract mucosal morphology as evaluated by optical microscopy was normalized as soon as the 3d post-operative day. From these data it may be assumed that in allotransplantations, optical microscopic abnormalities seen after the fourth post-operative day are no longer due to anoxia but may be related to early rejection. Other functional tests could be of some value only after the 15th day.

Animals↗