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Biomedical subjects

M Chalabala

Publications and source records attributed to M Chalabala.

At least 19 recordsLinked to original sources
PubMed1998

The use of some hydrophobic substances in tablet technology.

The objective of this work is to continue in a study of utilization of synthetic triacylglycerides of higher aliphatic acids as additives improving the flow properties of granulates and reducing die friction in the tabletting press. These effects are not supposed to interfere with the drug liberation velocity. We have evaluated the effects of the synthetic triacylglycerides in theophylline containing model tablets using magnesium stearate as the reference standard. Magnesium stearate is the lubricant of choice in the production, found in up to 80% of all industrially produced tablets.

Calorimetry, Differential Scanning↗
PubMed1995

[Theory and practice within the framework of pharmaceutical education].

The present paper deals with the problems of the graduate study of pharmacy with regard to the relationship of theoretical and practical teaching. The situation in Slovakia is discussed and compared with the present-day states in some countries of Western Europe.

Education, Pharmacy, Graduate↗
PubMed1995

[Drug forms for drug delivery into the gastrointestinal tract].

Most drugs introduced into the GIT are absorbed into the stomach and/or the small intestine according to their chemical character. Some drugs (their number is on the increase) require targeted supply to a certain site in the GIT if their biological activity is to be manifested and made use of. Fulfilling this condition, which concerns primarily peptides and proteins, requires adjustments of dosage forms. Much effort is put forth to shift absorption into the large intestine (colon), which is advantageous from the viewpoint of circadian biorhythms.

Biological Availability↗
PubMed1981

[Preparation of eye drops with zinc sulphate and adrenaline (author's transl)].

The preparation of stable composed eye drops with epinephrine, zinc sulfate and procaine was studied. It was proved that the preparation using Adrenalnum solutum Spofa does not guarantee sufficient stability. It follows from the results that the stability of eye drops can be prolonged from 2 or 3 d to 1 month by the addition of 0.05% L-cysteine, N-acetylcysteine and sodium metabisulfite respectively.

Acetylcysteine↗