Biomedical subjects

M Chamberland

Publications and source records attributed to M Chamberland.

21 records · Page 2Linked to original sources

PubMed1976

Combined serotyping and biotyping of Serratia marcescens.

The API (Analytab Products, Inc., New York, N.Y.) biotypes of 117 clinical isolates of Serratia marcescens were determined and fell into 13 different patterns. The O and H antigens were determined by tube agglutination, and 27 serotypes were identified. The biotype and serotype appeared to vary indepently. Serotyping and biotyping combined divided these isolates into 56 different types. There was a problem interpreting the end points for inositol fermentation and urease production, which could affect reproducibility of API biotypes. Biotyping is a simple way of screening for possible nosocomial outbreaks of S. marcescens.

Bacterial Infections↗

PubMedDate not supplied

Gene structure of human cardiac hormone precursor, pronatriodilatin.

Atrial cardiocytes contain granules typical of protein-secreting cells, and atrial extracts are known to contain a powerful natriuretic and diuretic activity and to possess smooth muscle relaxant activity. A variety of active atrial peptides have been isolated, including a family of related peptides showing natriuretic, diuretic and smooth muscle relaxant activities in rat and human atria; these peptides were named atrial natriuretic factor (ANF). Another unrelated peptide from pig atria, cardiodilatin, is thought to possess only smooth muscle relaxant activity. Its partial amino acid sequence shows no homology with ANF sequences. The sequence analysis of a large form (106 amino acids) of ANF and of ANF complementary DNA clones indicates that cardiodilatin and ANF peptides are synthesized from a common precursor. This precursor also contains a signal peptide sequence expected of a secretory protein. We now describe the complete structure and sequence of the human gene for this novel hormone precursor that we call pronatriodilatin.

Alleles↗

PubMedDate not supplied

[Paraneoplastic pemphigus and adenocarcinoma of the colon].

An increased incidence of cancer has been observed in patients with pemphigus and described mostly since the 1970. Lymphoreticular malignancies and thymomas were the most often reported neoplasms. Paraneoplastic pemphigus is a newly described syndrome with specific characteristics. In this report, a patient with pemphigus and colonic adenocarcinoma is described. In this case, clinical and histologic features suggest the diagnosis of paraneoplastic pemphigus which would be for the first time described in association with colonic adenocarcinoma.

Adenocarcinoma↗