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Biomedical subjects

M Chappell

Publications and source records attributed to M Chappell.

9 recordsLinked to original sources
PubMed1998

Familiarity breeds differentiation: a subjective-likelihood approach to the effects of experience in recognition memory.

With repeated exposure, people become better at identifying presented items and better at rejecting items that have not been presented. This differentiation effect is captured in a model consisting of item detectors that learn estimates of conditional probabilities of item features. The model is used to account for a number of findings in the recognition memory literature, including (a) the basic differentiation effect (strength-mirror effect), (b) the fact that adding items to a list reduces recognition accuracy (list-length effect) but extra study of some items does not reduce recognition accuracy for other items (null list-strength effect), (c) nonlinear effects of strengthening items on false recognition of similar distractors, (d) a number of different kinds of mirror effects, (e) appropriate z-ROC curves, and (f) one type of deviation from optimality exhibited in recognition experiments.

Humans↗
PubMed1985

Aprotinin induced lipohypertrophy and glomerulonephritis in an insulin dependent diabetic.

In an insulin dependent diabetic who was hyperglycaemic and ketotic despite 3,000 u of insulin injected subcutaneously in 2 divided doses daily, 50 u of intravenous insulin infused over 24 hr restored normal glucose homeostasis. A combination of insulin (800 u) and aprotinin (10,000 u) given twice daily also produced adequate glucose homeostasis for a period of 12 months. The patient then developed local hypertrophy of subcutaneous tissue at the injection site and her diabetic control deteriorated. Non-selective proteinuria followed and she developed nephrotic syndrome. Renal biopsy revealed a membraneous glomerulonephritis with subepithelial immune complexes, appearances consistent with a drug-induced glomerulonephritis. Withdrawal of aprotinin led to a gradual remission of nephrotic syndrome and proteinuria over several months. During this period, her diabetes was well controlled with continuous subcutaneous infusion of insulin at a dose of 500 u/24 hr. This case report demonstrates: the effective use of aprotinin for prolonged periods in insulin dependent diabetics with abnormal absorption of subcutaneously injected insulin; aprotinin induced lipohypertrophy which was not observed when insulin was injected alone; aprotinin-associated glomerulonephritis and nephrotic syndrome; the effective use of CSII--at higher insulin doses--in such patients with subcutaneous malabsorption of insulin.

Adipose Tissue↗