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Biomedical subjects

M Chatani

Publications and source records attributed to M Chatani.

At least 91 records · Page 5Linked to original sources
PubMed1985

[Radiation therapy for primary non-Hodgkin's lymphoma of the head and neck].

Thirty-seven previously untreated cases of primary non-Hodgkin's lymphoma in the head and neck were treated at our department from September 1977 through January 1983. The survival rate at three years by stage was 84% in stage I, 44% in stage II and 0% in stage III and IV. Stage, T- and B-cell markers, initial primary site, the level of lymph node involvement (UICC, 1978) and number were important prognostic factors. Chemotherapy in the pre- or post-radiation period was essential, especially in stage II. It was proved that adequacy of radiation portals with special reference to anatomical considerations was necessary.

Adolescent↗
PubMed1985

Rectal complication after remote afterloading intracavitary therapy for carcinoma of the uterine cervix.

From August 1978 through December 1980, 119 patients of previously untreated carcinoma of the uterine cervix were treated using RALS, remote afterloading high dose rate intracavitary therapy at our department. The data from 92 out of 119 patients were available for analysis of rectal complication. The incidence of major rectal complications was only 2% (2/92). Uni- and multivariate analyses were used based on the external criterion variable of rectal complication which included even minor injuries. By using these methods, it was clearly indicated that these factors such as TDF of rectum, Z-coordinate of weighted geometric center (WGC-Z), the dose of whole pelvic irradiation, history of chemotherapy and Treponema pallidum hemoagglutination test (TPHA) were important for occurrence of rectal complication. According to discriminant score, 71 out of 92 cases (77%) could be correctly discriminated.

Adult↗
PubMed1985

[Acinic cell tumor of the epipharynx--a patient treated with surgery and high-dose intracavitary radiation therapy].

A case of acinic cell tumor of the epipharynx is reported. The patient was a 41-year-old man. The tumor was surgically removed by the transpalatal approach. Light microscopically, the lesion was composed of serous acinic cells with eosinophilic granules, clear cells with water-clear cytoplasm and their intermediate type, vacuolated cells. The serous acinic cells were PAS (periodic acid-Schiff)- and DPAS (PAS with diastase predigestion)-positive. The clear and vacuolated cells were PAS- and DPAS-negative. The patient underwent early postoperative radiation therapy; high-dose intracavitary radiation therapy using remote-controlled afterloading equipment was given subsequent to the external radiation therapy. The patient has been free of recurrence and abnormal findings for one year after treatment.

Adult↗
PubMed1985

Immobilization and reproducibility in radiotherapy for cancer of the larynx and pharynx using simplified shell and bite-block.

In this paper we describe the comparative study concerning the immobilization during radiotherapy for cancer of the larynx and pharynx with or without shell and fixing device. Immobilization was continuously monitored by semi-conductor detector. Reproducibility was investigated by means of verification film. The result significantly indicated that better immobilization was obtained in the patients treated with use of the shell (p much less than 0.001). Reproducibility of the field arrangement was also sufficient throughout the course of radiotherapy.

Humans↗
PubMed1985

[Assessment of response to therapy based on the application of the guideline of reporting treatment results of head and neck cancer].

It seems difficult to compare the treatment results to each other, without "common language" to describe cancer therapy and its results. In this paper, guideline of reporting treatment results of head and neck cancer was applied to carcinoma of the pharynx and larynx. There were some problems in reporting of response, such as the measurability and assessment of the response. However, there were small discrepancies between assessment of response to therapy and end-point evaluation, i.e., long-term control, survival and disease-free survival, according to the prospective department-based and retrospective hospital-based studies.

Head and Neck Neoplasms↗
PubMed1984

[Central nervous system irradiation for children with leukemia].

Between 1972 and 1981, 247 patients with acute lymphoblastic leukemia were treated with prophylactic CNS irradiation. Cranial irradiation (2400 rad) plus intrathecal methotrexate was the prophylactic CNS therapy of choice. At 5 years, the overall, relapse-free and CNS relapse-free survival rates were 51%, 47% and 79%, respectively. Our findings suggest that more attention should be paid to the inferior border of the radiation field, since the anterior and middle cranial fossae were sometimes not included and the second spine was almost always excluded.

Adolescent↗
PubMed1984

[Investigation of rectal and bladder complications after RALS therapy for carcinoma of the uterine cervix].

From August 1978 through December, 1980, 119 patients with previously untreated carcinoma of the uterine cervix were treated using RALS, (remote-controlled) high dose rate intracavitary radiotherapy. The data from 92 out of the 119 cases were available for multivariate analysis for rectovesical complications. By using this method, it was clearly indicated that factors such as TDF of the rectum, weighted geometric center (WGC)-Z, the dose of whole pelvic irradiation, chemotherapy and TPHA were important in the occurrence of rectal complications. However, there was no definite physical or physiological factor to predict the occurrence of bladder complications.

Adult↗
PubMed1984

[Prophylactic central nervous system irradiation for childhood acute lymphoblastic leukemia].

Documentation on 324 children with leukemia who underwent cranial irradiation between 1972 and 1981 was collected from 15 participating hospitals in the Kansai Cancer therapy Group. Among 182 children with acute lymphoblastic leukemia, records on 90 children treated with prophylactic cranial irradiation (2,400 rads) plus intrathecal methotrexate in 12 hospitals were available for analysis. There was no significant difference in survival between the two prognostic groups based on age and initial WBC count at diagnosis, i.e., overall, relapse-free and CNS relapse-free 5-year survivals in the good and intermediate prognostic groups were 57% vs. 51%, 55%, vs. 49%, and 83% vs. 95%, respectively.

Adolescent↗
PubMed1984

[Evaluation of the accuracy in radiotherapy for carcinomas of the hypopharynx and larynx].

Immobility and reproducibility were investigated to evaluate the accuracy in radiotherapy for carcinomas of the hypopharynx and larynx. Based on our comparative study using a semi-conductor detector, a light-cast shell is sufficient to maintain immobility during radiotherapy. In most cases, the range of reproducibility was within 5 mm throughout the course of radiotherapy.

Humans↗
PubMed1983

Revaluation of treatment result of carcinoma of the hypopharynx using quantification II of multivariate analysis.

In a material of 336 patients with squamous cell carcinoma of the hypopharynx treated from 1956 to 1980, overall 5 year survival rate of carcinoma of the hypopharynx was 25%. According to the stage classification, 5 year survival rates were 74,41,28 and 7% in I,II,III and IV, respectively. As to the treatment modality, 5 year survival rates were 31,24,41,31 and 0% by surgery, radical radiotherapy, preoperative radiotherapy, radical radiotherapy with salvage surgery for recurrence and palliative treatment, respectively. Based on the application of quantification II, we may reasonably conclude that 3 year survivors are mainly discriminated by stage of the disease and treatment modality.

Carcinoma, Squamous Cell↗
PubMed1983

[Evaluation of radiation therapy of brain metastases from lung carcinoma using multivariate analysis].

A randomized clinical trial of whole brain irradiation for brain metastases arising from lung cancer is in progress to improve survival and the quality of life. Between September 1980 and July 1982, 40 patients were treated using 4 MV X-ray. Concerning the radiation dose, laboratory tests and the physical condition of the patients, we analyzed 22 data items by means of quantification II, one of the methods of multivariate analysis. We found that neurologic function, performance status and LDH are important factors in assessing the 120-day survival.

Adult↗
PubMed1982

Dynamic computed tomography of hepatocellular carcinoma.

Nineteen patients with clinically proven hepatocellular carcinoma were studied by dynamic computed tomographic (CT) scanning. Ten consecutive 3 sec scans were performed within 30 sec, providing uninterrupted data collection. Dynamic CT scanning was useful in recognizing tumor vascularity, multiple small tumors, isodense tumors on conventional CT scans, the capsule of an encapsulated hepatocellular carcinoma, arteriovenous shunts, and vascular pools. Time-density curves were useful in evaluating the hemodynamics of the tumors; these could be classified into three types according to differences in their enhancement patterns.

Aged↗
PubMedDate not supplied

Whole brain irradiation for metastases from lung carcinoma. A clinical investigation.

Sixty-nine consecutive patients with brain metastases from lung carcinoma were randomly allocated to one of two radiation therapy schedules: 30 Gy/10 fractions/2 weeks or 50 Gy/20 fractions/4 weeks. The improvement rate for neurologic function was similar in the two groups. The median survival times for patients receiving the short course and the long course were 4 months and 3 months, respectively. The half-year survival rate was 42 per cent after the short course and 14 per cent after the long course (p less than 0.05). Performance status and lactate dehydrogenase were other factors which significantly influenced the half-year survival rate.

Adenocarcinoma↗
PubMedDate not supplied

Radiation therapy for primary non-Hodgkin's lymphoma of the head and neck.

From October 1977 through September 1986, a total of 77 patients (Stage I, 26; II, 35; and III-IV, 16) with primary non-Hodgkin's lymphoma (NHL) of the head and neck were treated with radiation therapy and chemotherapy (CVP or CHOP regimen) or radiation therapy alone. Actuarial 5-year survival rates by stage were 79% in Stage I, 35% in II, and 8% in III-IV. Significant prognostic factors were clinical stage (p = 0.0001), histological grade by the Working Formulation (p = 0.0089), and surface marker (T and B cell analysis) (p = 0.0001). In Stage II patients, the serum lactate dehydrogenase (LDH) level (p = 0.0286), the number of cervical lymph nodes involved (p less than 0.03), and maintenance chemotherapy after initial treatment (p = 0.0077) were significant prognostic factors. In conclusion, more intensive chemoradiotherapy is necessary as the first-line treatment in those with poor prognosis, especially those with T-cell type and high grade histology. In addition, maintenance chemotherapy after initial chemoradiotherapy is very important for Stage II NHL patients, especially those with a high LDH value or multiple cervical lymph node involvement.

Antineoplastic Combined Chemotherapy Protocols↗
PubMedDate not supplied

Radiation therapy of the para-aortic lymph nodes in carcinoma of the uterine cervix: the concurrent use of cimetidine to reduce acute and subacute side effects from radiation.

A prospective study of the effects of radiation therapy (RT) on para-aortic lymph nodes in uterine cervical cancer was conducted. As part of the study, cimetidine (800 mg daily) was administered during RT to relieve and prevent adverse reactions of the gastrointestinal tract caused by RT. In half of the patients, cimetidine (400 mg daily) was continued after RT was finished. The RT field was 7 to 8 cm wide and covered the area from the 4th lumbar to 11th thoracic vertebrae. The total dose administered was 45 Gy in 25 fractions over a five-week period. From September 1986 through October 1987, 89 patients were entered in this study. During RT, only slight gastrointestinal symptoms, such as nausea, vomiting, appetite loss, fatigue, and epigastralgia, were observed. These symptoms increased when cimetidine was withdrawn, but not in the patients who continued to receive cimetidine. It is concluded that cimetidine during and after RT can reduce the acute and subacute side effects of RT.

Acute Disease↗