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Biomedical subjects

M Cherington

Publications and source records attributed to M Cherington.

17 recordsLinked to original sources
PubMed1992

Lightning strikes: nature of neurological damage in patients evaluated in hospital emergency departments.

Emergency physicians and staff are usually the first to evaluate and manage victims of lightning strikes. Damage to the nervous system is often the most devastating consequence of lightning strikes. Contrary to most articles in the literature in which neurological disorders are said to be either transient or delayed, we report the cases of six patients with severe, immediate, and in at least three, permanent clinical problems. Patients with signs of spinal cord lesions are most likely to have permanent disabilities.

Adolescent↗
PubMed1992

Thoracic outlet syndrome: reimbursement patterns and patient profiles.

Thoracic outlet syndrome (TOS) is one of the most controversial subjects in clinical medicine. In spite of the increasing skepticism voiced in the medical literature, many patients continue to be diagnosed as having TOS and treated surgically. Colorado is one of the leading states where TOS surgery is performed. We have examined the 1989 data as collected by the Colorado Hospital Association and have defined a patient profile and reimbursement pattern. Of the 174 patients who underwent surgery, women outnumbered men by three to one (132 to 47), even when worker's compensation was the payer. The data show that patients who do not have private insurance or worker's compensation are rarely diagnosed as having TOS. Medicaid patients almost never undergo surgery.

Adult↗
PubMed1990

Botulism.

Explore the source record for details and available documents.

Botulinum Toxins↗
PubMed1979

Facial myokymia.

Facial myokymia is an uncommon form of dyskinesia, usually resulting from a lesion in the brain stem. The electromyogram is typical. A case is reported. The condition was due to an astrocytoma of the brain stem.

Adult↗
PubMed1978

Botulism and guanidine. Ten years later.

Guanidine hydrochloride was introduced as an adjunct in the treatment of botulism in 1968. It has been reported to be of benefit in 39 cases and of no benefit in 13 cases. No serious side effects have occurred with the short-term therapy required in botulism. Our two cases are similar to earlier cases in that the improvement seen with quanidine therapy is most notable in ocular muscles and least notable in respiratory muscles. Electrophysiological findings again showed an increase in the amplitude of evoked muscle-action potentials after guanidine administration.

Adolescent↗
PubMed1977

Spinal myoclonus.

The focal involuntary muscular contractions of spinal myoclonus have been associated with neoplastic, infectious, traumatic, and degenerative lesions of the spinal cord. Four patients are described here. In two, the myoclonus is associated with severe cervical spondylitis. One patient had herpes zoster. In the fourth, a segment of thoracic spinal cord is narrow and probably atrophic. Both tetrabenazine and clonazepam were therapeutically effective.

Clonazepam↗
PubMed1977

Effect of guanidine, germine, and steroids in a case of botulism.

A patient with severe type A botulism demonstrated several interesting features. Characteristic electrophysiologic findings are not necessary for the diagnosis. Guanidine hydrochloride provided mild improvement. High doses of steroids and low dose of germine-monoacetate had no effect.

Action Potentials↗
PubMed1976

Guanidine and germine in Eaton-Lambert syndrome.

A 43-year-old man with Eaton-Lambert syndrome developed chronic interstitial nephritis after 4 years of guanidine hydrochloride therapy. The diagnosis of Eaton-Lambert syndrome was confirmed by clinical neurophysiologic studies and by intracellular electrode studies of end-plate potentials from an intercostal muscle biopsy. Because guanidine had toxic effects in this patient, an alternative form of therapy was tried. Germine-3-acetate (500 mg per day orally) resulted in clinical and electric improvement of the myasthenic syndrome. However, the sensory side effects of numbness of the limbs and unpleasant taste were sufficiently annoying that germine was discontinued.

Adult↗
PubMed1976

Locked-in syndrome caused by a tumor.

A case of locked-in syndrome is described. Clinical and radiologic evidence suggested the presence of a brain-stem tumor. Autopsy showed that the patient had a reticulum cell sarcoma. This is the first reported case of locked-in syndrome caused by a tumor.

Adult↗
PubMed1975

Wound botulism.

Botulism occurring in patients with wounds has been thought of as a rare disease. A patient with a lacerating wound of his hand and wrist and an avulsion of his fourth finger developed diplopia, dizziness, and slurred speech one week later, followed by generalized weakness and difficulty in swallowing. Repetitive nerve stimulation studies showed signs of neuromuscular block consistent with the diagnosis of botulism. Results of bacteriologic and immunologic tests were not revealing, but the subsequent course of progressing, and retrogressing, bulbar signs and symptoms with eventual nearcomplete recovery confirmed the diagnosis. Increasing awareness and employment of electrophysiologic studies are uncovering increasing numbers of cases.

Adult↗
PubMed1975

Amorphosynthesis on the chess board.

Visual spatial perception difficulities on the chest board have been studied in a patient with a dominant hemisphere infarction. The game of chess can be useful to demonstrate and follow the evolution of amorphosynthesis.

Adult↗