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Biomedical subjects

M Cinco

Publications and source records attributed to M Cinco.

At least 91 records · Page 5Linked to original sources
PubMed1980

Cytotoxic activity of supernatant extracts of virulent and saprophytic leptospires.

Extracts from supernatants, obtained from culture of virulent strain PB-3 and saprophytic strain Isola Sacra 1, were assayed for cytotoxicity. A cytotoxic factor produced by the pathogenic strain was found to affect specifically the tested cells, at determined concentrations; on the other side a not clear and scarce cytotoxicity was shown for the extract from the saprophytic strain Isola Sacra 1. Cytotoxic factor produced by strain PB-3 was heat resistant and trypsin sensitive, suggesting to be a thermostable protein. An inhibitory doses it induced a typical, cytopathic effect on the treated cells.

Animals↗
PubMed1979

Incompatibility of R plasmids from clinical material.

Thirteen R plasmids derived from strains of E Enterobacteriaceae isolated from clinical material have been characterized. They belonged to many incompatibility groups and differ widely respecting other phenotypic characteristics, even if they come from bacteria isolated from a small geographic area.

Anti-Bacterial Agents↗
PubMed1978

The immunoglobulins response in rabbit to single antigenic factors of leptospira. Investigations with two serovars from saprophytic leptospira.

The agglutinating antibodies formed after immunization of rabbits with viable leptospira consist of 19S and 7S immunoglobulins. IgM and IgG are formed already earlier in the course of immunization. after a lapse of one month more IgG is found than IgM. The specificity of agglutination with the main antigenic factors is due mainly to IgG.

Agglutination Tests↗
PubMed1977

Factor analysis of Basovizza serogroup of "Leptospira biflexa".

Factor analysis is performed on serotypes of Basovizza serogroup of "Leptospira biflexa". The results show the arrangement of main factors typical for the members of this serogroup as well as the antigens common with serotypes of the heterologous serogroup. The existence of a main haptene-like factor is also hypothesized.

Antigens, Bacterial↗
PubMed1975

Sensitivity in vitro of leptospira to oxamicetin.

Oxamicetin was tested against 12 strains of parasitic leptospira each representing a different serotype and serogroup, and 8 saprophytic strains in liquid media. The results showed general susceptibility of parasitic leptospira being MIC's from 0.1 to 0.5 mug/ml. The MIC's against saprophytic strains were 10 similar to 40 mug/ml.

Anti-Bacterial Agents↗
PubMedDate not supplied

Chemical and biological properties of a phenol-water extract from Leptospira interrogans. Evidence for the absence of lipopolysaccharide.

Leptospira interrogans, serovar copenhageni was extracted by the phenol-water method and the resulting preparation examined for chemical composition and endotoxic activity. Chemical analysis revealed that a number of sugars were present, however, the amount of lipid content was very low. Further, the preparation was devoid of characteristic endotoxic properties, like lethal toxicity, pyrogenicity and the property to induce the local Shwartzman reaction. The extract, however, was active in the limulus lysate gelation test and in the induction of monocyte activation. It is concluded that the leptospira preparation is devoid of endotoxin properties, both from the chemical and from the biological point of view.

Animals↗