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Biomedical subjects

M Colle

Publications and source records attributed to M Colle.

54 records · Page 3Linked to original sources
PubMed1982

[Echography in gonadal dysgenesis and ovarian dystrophy (author's transl)].

Pelvic ultrasound examination was performed in 28 patients presenting with disorder in the onset of puberty (13 suggesting gonadal dysgenesis and 15, ovarian hyperandrogenism). Results of this investigation were compared with those of coelioscopy, in order to establish the respective value of each technique in the diagnosis of disorders of puberty in girls. In patients with gonadal dysgenesis, echography may show 'residual gonads but coelioscopy remains necessary when results of radiologic investigation are negative, when clinical or hormonal data suggest that ovarian function is present. Ultrasound examination showed one or two enlarged ovaries in all but one patients in whom coelioscopy had shown this abnormality. Pelvic echography is now the first test to be performed in girls with disorders of puberty as it often permits to avoid coelioscopy.

Adolescent↗
PubMed1979

[Acanthosis nigricans, hirsutism and insulin-resistant diabetes].

Three girls, two of them being monozygotic twins, are affected with acanthosis nigricans and hirsutism, which worsened at the time of their puberty. The first one has primary amenorrhea and the twins complain of spaniomenorrhea. Furthermore, laboratory data concluded to diabetes, hyperinsulinism and resistance to insulin. This rare association of syndromes is not accidental but its significance remains unknown.

Acanthosis Nigricans↗
PubMedDate not supplied

[Heterogenity of the cryptorchid syndrome. Study of the pituitary gonadotropin reserve in 50 prepuberal bodys].

As compared to a control group, the study of the pituitary reserve of gonadotrophins in 50, not yet puberous, cryptorchid boys, evoked that there is a heterogeneity in cryptorchism. The LH pituitary reserve may be insufficient, normal or increased; the FSH pituitary reserve may be normal or above normal. A longitudinal study of these patients, as well as the correlations with ultra-structural and histologic studies should lead to a better understanding of the significance of the hormonal abnormalities encountered in cryptorchism, and to a better appreciation of the associated testicular changes.

Adolescent↗
PubMedDate not supplied

[21-Hydroxylase deficiency. Clinical expression of heterozygote carriers in a family].

The observation of a neonate who presented with congenital adrenal hyperplasia due to 21-hydroxylase deficiency and of her aunt who presented with primary amenorrhea and hirsutism led to the genetic study of this family. The ACTH stimulation test and HLA typing proved that the young woman was heterozygous for the C-21 block and that the niece presented with the homozygous condition. This case confirms that, in rare cases, the clinical expression of C-21 block may appear in heterozygous carriers.

17-alpha-Hydroxyprogesterone↗
PubMedDate not supplied

[Pelvic echographic data during normal and pathological development in girls].

From a population of 60 normal females divided in 4 groups of 15 according to age and puberty, standards of uterine length and ovarian volume as measured by ultrasonography were established. The length of the uterus increases moderately with age (mean: 26.4 mm under 2 years of age; 29.5 mm from 2 to 8 years; 36.5 mm from 8 to 12 years) and significantly with puberty (mean: 60 mm), as does the volume of the ovaries (mean: 0.98 cm3 from 8 to 12 years; 3.4 cm3 after puberty). These standards, confirming former data, allow a better understanding of ultrasonographic findings during pathologic growth in young females, such as precocious puberty, delayed puberty, hypopituitarism, or hyperandrogenism. Thus, this investigation may assume an important part in the diagnosis of disorders of puberty, as it is innocuous and may be repeated as often as necessary during the growth of young patients. As it is non invasive and inexpensive, it could be the first investigation in some of these indications.

Adolescent↗