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Biomedical subjects

M Colliard

Publications and source records attributed to M Colliard.

14 recordsLinked to original sources
PubMed1981

[Location of an insulinoma by transhepatic phlebography with staged insulin assays (author's transl)].

Insulinoma was easily diagnosed in a 73-year-old woman who had organic hypoglycaemia associated with hyperinsulinism, but the tumour could not be located by echotomography and computerized tomography. The state of the patient's arteries precluded arteriography. Pancreatic phlebography was carried out by the portal transhepatic route and blood was collected at different levels for plasma insulin assays. A very high gradient at the pancreatic isthmus indicated the site of the tumour, which was found on surgery to be precisely there and could be enucleated. This technique cannot be used systematically to locate insulinomas, but it is unquestionably helpful when the tumour cannot be located by other methods or when these are contra-indicated.

Adenoma, Islet Cell↗
PubMed1981

[Treatment of certain refractory arterial hypertensions with a monoamine oxidase inhibitor].

Sixteen patients with refractory hypertension were treated with the monoamine oxidase inhibitor iproclozide at doses of 10 to 30 mg/day. Its addition to the previously prescribed antihypertensive therapy resulted in normalisation of blood pressure readings in two cases, significant improvement in seven cases and no change in four cases. Side effects due to iproclozide were relatively minor, the treatment having to be discontinued in three cases. Its association with alpha methyldopa or spironolactone did not lead to any untoward complications. Despite the success of other recently introduced drugs in refractory hypertension, this study shows that MAOI may be very useful in the management of this condition.

Female↗
PubMed1980

[Microangiopathy of the diabetic type, without carbohydrate intolerance (author's transl)].

Pathophysiology of diabetic microangiopathy is unclear, but hyperglycemia is admitted as an important factor. In three patients having microangiopathy with lesions very similar to those of diabetes (one nodular glomerulosclerosis, two retinopathies), glucose tolerance was found normal. Such cases, already reported, but rather rare, raise the question of the validity of tests currently used in the diagnosis of diabetes, of the importance of hyperglycemia compared to others factors (specially genetic) in the occurrence of microangiopathy, and of the specificity of these lesions.

Aged↗
PubMed1980

[Sipple's syndrome: a study through three generations. HLA--carcino-embryonic antigen system. Preliminary results (author's transl)].

Sipple's syndrome in three members of the same family (three successive generations) is reported, confirming that this syndrome is hereditary and transmitted in an autosomal and dominant way. Whereas pheochromocytoma was clinically detectable, medullary thyroïd carcinoma could only be detected in two cases by systematic search for high levels of calcitonin before and after stimulation. In 6 other siblings, thyroïd carcinoma was eliminated in view of negative stimulation tests. HLA groups were studied, but definite conclusions as to the interest of these data in Sipple's syndrome cannot be drawn from 10 few cases. Persistingly high levels of calcitonin after surgery is known to be of severe prognosis; in the present cases, the very short delay after surgery did not allow definite conclusion, since, according to some authors, several months are necessary to allow a return to normal levels.

Adrenal Gland Neoplasms↗
PubMed1979

[Does the insulin-secretion capacity of non-diabetic subjects possess a prognostic value? (author's transl)].

Twenty-two patients, whose initial oral glucose tolerance test (OGTT) was not diabetic, but who possibly had predisposition for diabetes, underwent iterative OGTT with plasma insulin determination and estimate of insulin-secretion capacity (plasma insulin area/blood glucose area ratio, and insulin-secretion coefficient). With a 30 months mean time interval between the two tests, a highly significant negative correlation was found between insulin-secretion capacity of the first test and blood glucose area of the last one. Glycemic curve of the OGTT was diabetic in 3 cases at the final test. Thus, it seems possible to select subjects most prone to future diabetes with simple parameters estimating insulin-secretion capacity during OGTT.

Adolescent↗
PubMedDate not supplied

[Tomodensitometry: localizing value in hypertension of adrenal origin (author's transl)].

Computarized axial tomography has shown the localization of adrenal lesions in four cases of hypertension of adrenal origin: two phaeochromocytomas, one primary hyperaldosteronism, one Cushing's syndrome. This method has the advantage of being neither invasive, nor time-consuming. Unfortunately, it cannot localize tumors smaller than two cm in diameter. It seems to be highly beneficial in phaeochromocytoma, where it can advantageously take the place of arteriography. It is less fruitful in primary hyperaldosteronism and in Cushing's syndrome because lesions are smaller.

Adrenal Gland Neoplasms↗
PubMedDate not supplied

[Results of treatment of Graves' disease by antithyroid drugs. Report of 90 cases (author's transl)].

Ninety patients with Graves' disease were given treatment with antithyroid drugs. The first course, which is almost always immediately successful, gave in the long term 46 failures and 44 successes. Among the latter, 38 had a follow up equal or greater than one year after interruption of the course. Among the 78 cases sufficiently well followed up for the whole period of treatment (of which 21 had at least two courses of treatment), we noted 23 failures and 55 successes (70%) for which the average follow up was 61 months. If one requires a follow up equal or greater than one year after the end of treatment, we noted 47 good results out of 70 fully documented cases, i. e. 67%. The possible failures almost always occurred less than one year after the end of treatment. The delay since the last interruption of antithyroid drugs is thus of prognostic value. The result of treatment was not found to be related to any of the clinical or laboratory parameters found during the initial stage of the disease, nor with the type of antithyroid drug used. The addition of thyroid hormone to antithyroid drugs does not seem to be of any use. On the other hand, delay in starting treatment seems to favour the failure of treatment. Other interesting prognostic factors may be sought in the kinetics of TSH, the T3-suppressibility, the early radioiodine uptake, the estimation of thyrostimulating antibodies, and the study of HLA histocompatibility antigens.

Adolescent↗
PubMedDate not supplied

[Hypertension and oral contraceptive therapy (author's transl)].

Twenty-nine patients, either taking oral contraceptives or having stopped since less than six months, were referred for hypertension. Three conditions have to be satisfied in order to incriminate with certainty the responsibility of oral contraceptives inducing hypertension : normal blood pressure before therapy (included pregnancies), normalization of blood pressure in a delay of three months at most after the discontinuation, no other etiology of hypertension. The small number of hypertensions really induced by oral contraceptives is opposed with the great number of hypertension (essential or not) revealed by oral contraceptives.

Adult↗
PubMedDate not supplied

[Effect of long-term therapy of essential hypertension on serum creatinine, electrocardiogram and eyeground status: a study of 71 patients over 7 years (author's transl)].

71 patients with essential hypertension have been followed for 7 years under effective anti-hypertensive therapy. Significant decrease in mean blood pressure was noted at the end of the first year and progressed linearly thereafter. Serum creatinine rose slightly, probably due to diuretics. Eyegrounds improved sharply during the first year, but deteriorated slightly thereafter: this may be due to increasing arteriosclerosis and validity of classification is questioned. Electrocardiogram improved during the first year, singularly in men: correlation with reduction in blood pressure was not clear. This discrepancy is discussed. It is concluded that improvement is sufficient to justify a continued treatment in this type of hypertension.

Adult↗
PubMedDate not supplied

[Hypertensive patients treated with tielinic acid. A retrospective study of 298 cases (author's transl)].

Two-hundred and ninety-eight hypertensive patients received tielinic acid for a period of 4 to 42 months; in 295 cases the drug was combined with a potassium-sparing diuretic. No significant changes in mean serum creatinine levels were observed in the whole group. The slight rise in serum creatinine which occurred in 17 patients cannot be ascribed with certainty to the combined treatment. Two patients developed cytolytic hepatitis, and of the 253 patients whose serum transaminase levels were systematically measured, 18 had moderately increased levels; here again, the responsibility of the drug could not be fully established. These data suggest that combining tielinic acid with a potassium-sparing diuretic carries little risk of renal impairment and that this treatment can safely be used. The risk of liver damage is unquestionable but probably small no greater than that of other commonly used hepatotoxic drugs, notably allopurinol.

Chemical and Drug Induced Liver Injury↗