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Biomedical subjects

M Comerford

Publications and source records attributed to M Comerford.

At least 19 recordsLinked to original sources
PubMed2002

High risk sexual behaviours among heroin sniffers who have no history of injection drug use: implications for HIV risk reduction.

The purpose of this paper is to assess sexual behaviours which place heroin sniffers (HSs) at high risk for HIV infection. A stratified network-based sample was used to recruit HSs who had no history of injection drug use was recruited from the streets of South Florida, USA. HSs displayed a high HIV seroprevalence rate of 12.1%; women (18.1%) were more likely than men (8.7%) to test positive for HIV. Both men and women HSs engaged in considerable high risk sex behaviour, including high risk sex-exchange behaviour. The use of crack cocaine was associated with increased sex exchange behaviour among women. The need for intervention programs targeted toward HSs is discussed.

Cocaine-Related Disorders↗
PubMed2001

A comparison of HIV risk behaviors between new and long-term injection drug users.

The purpose of this study was to characterize the injection and sexual risk behaviors of a cohort of active drug injectors who have initiated injection within the past 4 years and to compare their behaviors with the risk behaviors of long-term injectors who have been injecting drugs since 1984. A stratified, network-based sample was used to recruit injection drug users from the streets in Miami-Dade, Florida. After screening for eligibility, which included a urine test to confirm current drug use, participants were administered a structured questionnaire that included basic demographic information, drug-use history, and HIV risk behavior practices. Both injector groups displayed a high level of HIV injection risk behavior. Although new initiates into injection demonstrated lower risk behavior than long-term injectors at the first injection episode, the current risk behavior between new and long-term injectors is similar.

Acquired Immunodeficiency Syndrome↗
PubMed2000

First injection and current risk factors for HIV among new and long-term injection drug users.

The purpose of this paper is to estimate HIV seroprevalence and to examine the injection and sexual risk behaviours of a cohort of active new heroin injectors who have initiated injection within the past four years and to compare their risk behaviours with those of long-term heroin injectors who initiated injection prior to January 1, 1985. A stratified network-based sample was used to recruit injection drug users (IDUs) from the streets of Miami-Dade, Florida. New IDUs displayed a significantly lower HIV seroprevalence than long-term injectors (13.3 versus 24.7%). Both new and long-term drug injectors exhibited a high level of current HIV risk behaviour. While new injectors were more likely than long-term injectors to practise safer injection behaviours at the initial injection episode, the current risk behaviours of new and long-term injectors are similar.

Adult↗
PubMed1997

Safe epidural analgesia in thirty parturients with platelet counts between 69,000 and 98,000 mm(-3).

Regional anesthesia is a popular form of pain relief for the management of labor and delivery. Thrombocytopenia is considered a relative contraindication to the administration of regional anesthesia. Some authorities have recommended that an epidural anesthetic be withheld if the platelet count is <100,000 mm(-3). For the period of March 1993 through February 1996, we reviewed the charts of all parturients who had a platelet count <100,000 mm(-3) during the peripartum period. Eighty women met this criterion. Of these 80, 30 had an epidural anesthetic placed when the platelet count was <100,000 mm(-3) (range 69,000-98,000 mm(-3)), 22 had an epidural anesthetic placed with a platelet count >100,000 mm(-3) that subsequently decreased below 100,000 mm(-3), and 28 did not receive a regional anesthetic. We found no documentation of any neurologic complications in the medical records. We conclude that regional anesthesia should not necessarily be withheld when the platelet count is <100,000 mm(-3).

Analgesia, Epidural↗
PubMed1995

Risk factors for HIV-1 seroconversion among injection drug users: a case-control study.

OBJECTIVES: A nested case-control study was conducted in Miami, Fla, to determine risk factors associated with human immunodeficiency virus type 1 (HIV-1) seroconversion among injection drug users. METHODS: The study identified 21 incident cases of HIV-1 infection and 76 unmatched controls from two longitudinal cohorts of injection drug users. One cohort consisted of individuals who originally had been recruited from treatment centers; a second cohort was recruited from the "street." Logistic regression analyses that adjusted for age, gender, and race were performed. RESULTS: The final model determined that the primary independent risk factor that best explained the risk for seroconversion was sharing injection equipment in the year prior to conversion; a marginal risk factor was presence of sexually transmitted disease during this same period. CONCLUSIONS: Both an injection component and a sexual component play a role in seroconversion among injection drug users, although the injection component is much stronger.

Adult↗
PubMed1994

The consistency of self-reported HIV risk behavior among injection drug users.

OBJECTIVES: Most studies of risk factors for human immunodeficiency virus (HIV) rely heavily on retrospective self-reports. The degree to which these reports provide reliable information has received little research attention. The purpose of this study was to assess the extent to which the reliability of retrospective self-report data is affected over time. METHODS: Data were examined from a longitudinal study of risk behaviors among injection drug users. Structured interviews were administered to 366 injection drug users who were asked to recall behaviors that they had reported 6, 12, or 18 months earlier. RESULTS: Kappa coefficients showed moderate initial memory loss for injection and sexual risk behaviors. After 6 months, time had little effect on the ability of injection drug users to recall injection and sexual risk behaviors. For ordinal measures of risk, subjects who gave different reports over time were most likely to disagree by one response category. CONCLUSIONS: These findings support the use of retrospective self-reports in assessing HIV risk behaviors among injection drug users. Retrospective inquiry is likely to remain an important method for collecting data over time.

Adolescent↗
PubMed1991

The donation and sale of blood by intravenous drug users.

In spite of efforts to dissuade intravenous drug users (IVDUs) from donating or selling blood, some continue to do so. As part of a longitudinal study, 915 IVDUs in South Florida were interviewed concerning their history of donation or sale of blood and tested for antibodies to HIV-1 and HTLV-I/II. Approximately 17 percent had either donated or sold blood during 1985 through 1988; most contributors (80.4 percent) sold to commercial blood services. IVDUs who had donated/sold blood were more likely to be male and not in drug treatment than were those who had not contributed blood. IVDUs not in treatment at the time of interview were more likely than IVDUs in treatment to have sold blood. Of those who had donated/sold blood since 1985, 19.6 percent subsequently tested positive for antibodies to HIV-1 and 5.7 percent were positive for antibodies to HTLV-I/II. Increased effort is required to screen prospective donors and sellers, particularly at commercial blood banks.

Adult↗
PubMed1990

Epidemiology of cancer among Hispanic males. The experience in Florida.

To assess cancer incidence among Hispanic males in Dade County, Florida, data were analyzed from the statewide tumor registry. For all cancer sites (combined), the age standardized rate among Hispanic males was 308.75 cases per 100,000 person-years, compared with 349.55 among non-Hispanics (standardized rate ratio [SRR] = 0.88; 95% confidence interval [CI] = 0.84-0.93). Hispanics experienced significantly greater rates of cancers of the larynx (SRR = 1.58; 1.19-2.09), thyroid (SRR = 3.12; 1.18-8.26), and gallbladder (SRR = 5.45; 1.55-19.15), compared with non-Hispanics, but significantly lower rates of testicular cancer (SRR = 0.17; 0.09-0.37), melanoma (SRR = 0.20; 0.12-0.34), esophagus (SRR = 0.52; 0.49-0.55), stomach (SRR = 0.61; 0.43-0.87), pancreas (SRR = 0.65; 0.45-0.94), kidney and renal pelvis (SRR = 0.68; 0.48-0.97), colon (SRR = 0.79; 0.67-0.94), lung (SRR = 0.82; 0.73-0.94), and Kaposi's sarcoma (SRR = 0.03; 0.00-0.25). These data suggest that Dade Hispanic males have not experienced the cancers traditionally elevated among US Latinos, or those common among non-Hispanics.

Adult↗
PubMed1990

HIV seropositivity of needles from shooting galleries in south Florida.

Needle/syringe combinations were collected from three shooting galleries in South Florida and tested for the presence of antibodies to HIV-1. Fifteen of 148 needles (10.1 percent) tested positive for HIV-1 antibody. Seropositivity rates did not vary by the day of the week of collection, nor by shooting gallery from which they were collected. When the needle appeared to contain blood residue, 20.0 percent were positive versus 5.1 percent with no blood residue. These findings suggest that needles/syringes used in shooting galleries are likely to serve as reservoirs and/or vectors of transmission of the HIV-1 virus, and that although visual inspection of the needle/syringe may be useful in lessening the chance for transmission, even the visually "clean" needles may result in transmission of infection.

Acquired Immunodeficiency Syndrome↗
PubMed1985

Predictive value of HLA antigen for methotrexate-induced liver damage in patients with psoriasis.

For an investigation of a possible association between HLA antigens and postmethotrexate liver damage, the A, B, C, and Dr loci of the HLA antigens were determined in thirty-two patients with severe psoriasis who had been treated with methotrexate. There was no association between HLA antigens and increasing severity of liver disease in these patients. HLA-A3 was increased in frequency in the group of patients with the more severe liver damage but was not significant when corrected for the number of antigens tested. There appears to be no predictive value in HLA typing of psoriasis patients prior to starting methotrexate therapy.

Adult↗
PubMed1984

Control of epidermal cell proliferation in vitro.

Epidermis from explants of keratome slices of domestic pig skin can be induced to migrate, proliferate, and stratify if at least two serum protein factors and a source of nucleosides are present. The factor which is necessary for cell movement or spreading is destroyed by heating the serum to 100 degrees C and is resistant to 80 degrees C heating. This factor has a molecular weight of 65,000 and is identical to the 'epibolin' found by Stenn. Proliferation is dependent on a serum factor which is destroyed by heating to 80 degrees C. However, cells which are denied this factor can make their own proliferation factor(s). Cell migration and cell proliferation usually occur together but they can be dissociated and are therefore independent phenomena. Increased cell proliferation can be achieved by some retinoids at the proper concentration but steroids, epidermal growth factor, a phorbol ester (TPA), and the use of injured skin as a keratome source failed to show in vitro hyperproliferation. Mitotic inhibition, however, can be induced by a variety of metabolic poisons (methotrexate, 5-fluorouracil, hydroxyurea), steroids, retinoids at high concentrations, and agents which increase adenosine 3',5'-monophosphate (cAMP).

Adenosine↗
PubMed1983

Agents that activate cyclic AMP-dependent protein kinase inhibit explant culture growth and mitotic activity.

Epidermal cells contain 4 separate surface receptors which are linked to adenylate cyclase. Activation of any one of these receptors leads to the accumulation of cAMP within the cell which in turn leads to the activation of cAMP-dependent protein kinase. The levels of cAMP accumulation within the cell caused by the 4 activators are not the same. Epinephrine, histamine, adenosine, and prostaglandins of the "E" series cause easily measurable concentrations of cAMP within 5 min of exposure. Prostaglandin F2 alpha causes only a small nonsignificant increase. Similarly, 2 phosphodiesterase inhibitors, which inhibit the breakdown of cAMP formed within the cell, differ in their ability to accumulate cAMP when cells are exposed to these agents alone. Isobutylmethylxanthine causes a measurable increase in cAMP, while theophylline, a weak inhibitor of phosphodiesterase, gives a nonsignificant increase in cAMP. Recently, experiments have shown that agents that give only slight increases in cAMP by biochemical measurements, that is, prostaglandins F2 alpha and theophylline, are equally able to activate protein kinase within the cell. Since activation of protein kinase is the only mechanism for an increase in cAMP to have a physiologic effect, all of these agents that do activate protein kinase should cause physiologic effects. Using an explant culture system, we show in this paper that this supposition is correct and that all agents that activate protein kinase do result in inhibition of mitotic activity regardless of whether or not they are able to raise cAMP to a level that can be biochemically measured as being significantly different from the baseline value.

1-Methyl-3-isobutylxanthine↗
PubMed1982

Constant low-dose ultraviolet light therapy for psoriasis.

In a bilateral comparison study, symmetric plaques of psoriasis were used to compare the effects of a constant low dose (3 minutes, 30 seconds) of ultraviolet light therapy to the standard increasing ultraviolet light dose. The low constant dose of ultraviolet light was as efficacious in clearing psoriasis lesions as the higher increasing dose.

Adult↗