Biomedical subjects
Publications and source records attributed to M Corbo.
The diagnostic value of nerve and muscle biopsy in detecting several neurological diseases is discussed. A bioptic technique for current surgical practice is proposed.
A case of HMN, distal type transmitted as autosomal dominant is described. Clinical findings appear to be consistent with a peroneal muscular atrophy, indistinguishable from HMSN types I and II. The electrophysiological data reveal a pathological involvement of the anterior horns, whereas sensory and motor conduction are normal. A muscle biopsy showed neurogenic atrophy, while the morphology of the sural nerve was normal.
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A case of membranous lipodystrophy (ML) with peripheral polyneuropathy (PN) is described. A 40-year-old woman presented with dementia, multiple lytic bone lesions with typical membranous material in adipose tissues and neurophysiological and pathological findings of peripheral neuropathy. We describe the first case of ML with PN. It is interesting since nerve involvement might be an additional cause of symptoms usually attributed to bone lesions.
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Nervous system involvement is rare in progressive systemic sclerosis (PSS). We present a clinical pathological and immunological study of two patients with peripheral sensory motor neuropathy and PSS. In both, the sural nerve biopsies showed axonal degeneration with increased endoneurial connective tissue. There were also clusters of myelinated fibres indicating axonal regeneration. Only mild microangiopathic changes were evident in the endo, peri and epineurial vessels. By Western immunoblots, patients' sera contained a band of reactivity to a protein from peripheral nerve identified as collagen type I. Primary involvement of the peripheral nerves during PSS is very unusual. Abnormal production of collagen tissue and presence of microvascular disease are considered to be two possible causes of neuropathy. We think that our results suggest the important role of the connective tissue proliferation in the pathogenesis of PSS neuropathy.
In this paper, the authors discuss 51 cases of uterine fibromatosis complicating pregnancy. From resulting data, and from an evaluation of the literature data, there emerges the present tendency to effect a conservative therapy of fibromas complicating a pregnancy.
In this paper, the authors discuss 22 cases of ovarian tumefaction in post menopausal age examining them clinically vaginal echography and dosages of CA 125 and 19.9, finding a good correlation between this routine diagnosis and the suspician of ovarian neoplasia.
In this paper, the authors discuss the utility of the trans-vaginal probe for an early diagnosis of fetal malformation, and specifically for the omphalocele.