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Biomedical subjects

M Corda

Publications and source records attributed to M Corda.

50 records · Page 3Linked to original sources
PubMed1966

Reflex and cerebellar influences on alpha and on 'rhythmic' and 'tonic' gamma activity in the intercostal muscle.

1. Efferent intercostal alpha and gamma activity and afferent intercostal muscle spindle activity were studied in decerebrate cats in response to stimulation of the anterior lobe of the cerebellum and to postural and other reflexes.2. Low threshold intercostal responses were elicited from lobuli IV and V of the anterior lobe of the cerebellum.3. The existence of two functionally different types of intercostal gamma neurones has been confirmed. These are the ;rhythmic' or ;specifically respiratory' gamma neurones, and the ;tonic' gamma neurones.4. In response to cerebellar stimulation, facilitatory, inhibitory and diphasic tetanic and post-tetanic effects were obtained from alpha and the two types of gamma fibres in both external and internal intercostal nerve branches.5. Generally both inspiratory and expiratory alpha and gamma activity was facilitated in response to tetanic stimulation at contralateral stimulus sites, and inhibited in response to stimulation of ipsilateral sites.6. ;Rhythmic' gamma activity appeared to be rather closely linked to the respiratory alpha activity but the balance between ;rhythmic' gamma and alpha was often changed in response to cerebellar stimulation, as indicated by the responses of primary muscle spindle afferents.7. The ;tonic' gamma neurones were as a rule more responsive to cerebellar stimulation than were the alpha and ;rhythmic' gamma neurones. Long-lasting post-tetanic effects were much more prominent in the ;tonic' gamma fibres than in the alpha or ;rhythmic' gamma fibres.8. ;Rhythmic' gamma activity was abolished after cervical transections of the cord. ;Tonic' gamma activity remained in the spinal preparations although usually at a different discharge rate.9. ;Tonic' gamma neurones were more responsive than the ;rhythmic' gamma neurones to the proprioceptive gamma reflex elicited by passive movements of the chest wall as well as to other spinal and supraspinal reflexes.10. Both ;dynamic' and ;static' gamma fibres seem to be represented in the group of ;tonic' intercostal gamma neurones.11. The significance of the results are discussed with regard to the following two main points: (a) integration of respiratory and postural functions of the intercostal muscles; (b) cerebellar control of the alpha-gamma balance in active contractions and passive relaxations.

Animals↗
PubMedDate not supplied

[Microbiological drawings in pneumology (author's transl)].

Microbiological examinations of the sputum for clinical purposes is often not satisfactory or useless. Suitability, chances of oropharyngeal contamination, hazards for the patients and clinical indications of the various drawing methods for tracheobronchial secretions and exudates are different. Transcutaneous tracheal aspiration is easy, reliable and safe.

Exudates and Transudates↗
PubMedDate not supplied

[Diastolic heart failure].

Until recently, the development of heart failure was related exclusively to the acute or chronic impairment in systolic function. Currently, the concept of heart failure not sustained primarily by a significant reduction in contractility has been clearly defined by several epidemiological and pathophysiological observations. This condition, defined as 'diastolic heart failure' or 'heart failure with preserved systolic function' can be related to different cardiac diseases with a higher prevalence in the elderly. Afterload mismatch situations, such as hypertension or aortic stenosis, as well as hypertrophic cardiomyopathy or pericardial diseases, determine this common clinical syndrome more frequently. Currently, the treatment of diastolic heart failure is still empirical, as there are few and inconclusive data coming from evidence-based medicine.

Diastole↗
PubMedDate not supplied

Diamine oxidase from horse kidney: ionic strength dependence of stability and activity.

Diamine oxidase was prepared from horse kidney by a procedure involving heat denaturation at 50 degrees C, ammonium sulfate fractionation, chromatography on hydroxyapatite and on G-200 Sephadex columns. This procedure gave about 1000 fold purification over the crude kidney cortex homogenate. The enzyme preparations thus obtained are stable only at high ionic strength. The effect on enzyme activity of salt concentration and various stabilizing agents have been investigated. The horse kidney diamine oxidase is irreversibly inhibited by carbonyl reagents and shows substrate specificity quite similar to other animal diamine oxidases.

Amine Oxidase (Copper-Containing)↗
PubMedDate not supplied

[Practical importance of quantitative bacteriology in pneumology. Preliminary studies].

Some ascertained the utility of the quantitative bacteriology in pneumology especially for the diagnosis of acute bronchopulmonary infections. Miles and Mizra technique lightly changed as analytically here described is suitable for counts of viable bacteria in sputum after liquefaction by N-acetyl-l-cisteine. Some researches prove that the technique is convenient for the control of chronic bronchopulmonary infections too with some restrictions. Quantitative tests are important to ascertain aetiological function of the bacteria in sputum and in bronchial secretions. Particularly 10(7)-10(9) coliforms per ml of sputum are likely pathogenic. The observation of the early quantitative changes of bacteria in sputum during antibiotic treatments is suitable for in vivo tests of microbial sensitivity to drugs and is preferable to the usual in vitro antibiograms.

Acute Disease↗
PubMedDate not supplied

[Clinical problems about microbiological findings in pneumology (author's transl)].

Identification for clinical purposes of the etiological germs in individual cases of bronchopulmonary not tuberculous infections is usually very hard. Sometimes, particularly in acute cases, microbiological counts in sputum as in tracheobronchial secretions and exudates may be useful. In some chronic cases an amount of particular bacteria in tracheal (transcutaneous) secretion larger than in sputum is to consider an etiological sign.

Acute Disease↗
PubMedDate not supplied

Oxidation of selenocystamine by diamineoxidase.

Selenocystamine is oxidatively deaminated by pig kidney diamineoxidase. The first product of the reaction is the corresponding cyclized aminoaldehyde, selenocystaldimine, which then undergoes further degradation. The oxidative deamination is thus the first step of a series of cyclic reactions which give rise to extensive cleavage of selenocystamine.

Amine Oxidase (Copper-Containing)↗