Biomedical subjects

M Corre

Publications and source records attributed to M Corre.

3 recordsLinked to original sources

PubMed1979

Percentage binding of testosterone and dihydrotestosterone and unbound testosterone and dihydrotestosterone in rabbit maternal and fetal plasma during sexual organogenesis.

The percentages of bound testosterone (17 beta-hydroxy-4-androsten-3-one; T) and dihydrotestosterone (17 beta-hydroxy-5 alpha-androstan-3-one; DHT) and their unbound concentrations were determined in pregnant rabbits and their fetuses from the 18th day of gestation to birth. T and DHT were also measured in fetal testes. In the testis, the total T/total DHT ratio, very high at 22 days (73.7 +/- 15.2), decreased until birth (6.7 +/- 0.8). In male fetuses the concentrations of total and unbound circulating T and DHT were always low and did not show any peak during sexual organogenesis. The percent binding of T (from 73.0 +/- 0.5 to 77.6 +/- 0.6) and DHT (from 76.5 to 83.7 +/- 1.1) in fetuses were similar in both sexes and significantly lower than those measured in mothers (T: from 87.2 +/- 0.6 to 91.6 +/- 0.9; DHT: from 87.3 +/- 0.9 to 93.8 +/- 0.9).

Animals↗

PubMed1979

Changes in the testosterone to dihydrotestosterone ratio in plasma and testes of maturing rabbits.

Testosterone (T) and dihydrostestosterone (DHT) were radioimmunologically assayed in the testes and plasma of rabbits at 1, 10, 20, 40, and 60 days of age and at 3, 4, 5, and 8 months. In the testis (nanograms per 100 mg testis) and plasma (picograms per ml), both hormones are low at birth, reach their maxima between 60--90 days, and then decline and remain low after 120 days. In the testes, the T:DHT ratio is very high from birth (4.2 +/- 0.4) to 60 days (8.8 +/- 1.1). A significant decrease (P less than 0.001) occurs between 60 (8.8 +/- 1.1) and 90 (1.2 +/- 0.1) days. The T:DHT ratio is always less than or equal to unity after 90 days. From 1--60 days, T is the dominant testicular hormone, while the levels of DHT are greater than or equal to those of T after 60 days. The mean value of the plasma T:DHT ratio is always greater than unity from birth (1.7 +/- 0.4) to adulthood (2.6 +/- 0.7). The dominant circulating hormone, at all ages, is T. Our results show that sexual maturation in rabbits is characterized by an inversion of the T:DHT ratio in the testes but not in the plasma.

Aging↗

PubMed1978

[Binding of testosterone and dihydrotestosterone to plasma proteins in rabbits under different physiological conditions].

Percent binding and unbound levels of T and DHT were determined in rabbits of both sexes at the end of intra-uterine life, ten days of age and adulthood. For both hormones, the lowest percent binding were observed in fetus, the highest in immature animals. The percent binding of T and DHT were significantly higher in adult females than in age-paired males. In pregnant mothers the percent binding of T and DHT were lowered.

Animals↗