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Biomedical subjects

M Coulon

Publications and source records attributed to M Coulon.

24 records · Page 2Linked to original sources
PubMedDate not supplied

Local thrombolytic infusion in arterial ischemia of the upper limb: mid-term results.

PURPOSE: Evaluation of local thrombolytic infusion in arterial ischemia of the upper limbs. METHODS: Thirteen patients, 4 male and 9 female, aged 31 to 83 (mean 63.6) were treated. The occlusion was determined to be thrombosis in 6 and cardiogenic embolism in 7 patients. Duration of symptoms varied from 2 hours to 3 weeks. Streptokinase (SK) was used in 4 patients at a rate of 5,000 units per hour, Urokinase (UK) in 8 patients at a rate of 75,000 units per hour and r-tPA in 1 patient at a rate of 4 mg per hour for 5 hours. Mean duration of infusion was 16 hours (3-39 hr) for SK and 35 hours (10-93 hr) for UK. Heparin was administered concommitantly at a rate of 300 to 1000 units per hour without a loading dose. RESULTS: Clinical limb salvage was obtained in all patients. Angiography showed complete clot dissolution and full clinical recovery in 8 patients. Five patients had partial clot clearing, 3 with full recovery and 2 with modest residual symptoms. One patient incurred a catheter-related transient cerebral ischemia, 1 patient a large arm hematoma from catheter-related trauma and 6 patients a moderate puncture site hematoma. Three patients died during the first month due to stroke, ventricular fibrillation, or cardiac failure, and 1 patient after 22 months from cardiac failure. No limb ischemia recurred during a follow-up of 1 to 5 years. CONCLUSION: Local thrombolytic infusion is a safe and effective treatment for acute and subacute upper extremity arterial thromboembolism.

Arm↗
PubMedDate not supplied

Tension mediastinal emphysema: emergency percutaneous drainage with CT guidance.

Four patients aged 8 to 54 years, under mechanical ventilation, presented with sudden tension mediastinal emphysema and exhibited typical clinical symptoms of compromised venous return. Diagnosis of tension mediastinal emphysema was confirmed by CT. A percutaneous catheter with a diameter varying from F12 to F20 was inserted in the anterior mediastinal compartment with CT control and connected to a waterseal aspiration. Emergency treatment was efficient in all patients. Percutaneous aspiration was continued for 3 to 20 days.

Adult↗
PubMedDate not supplied

Analysis of deletions in DNA from patients with Becker and Duchenne muscular dystrophy.

Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder for which the biochemical defect is as yet unknown. Recently, two cloned segments of human X-chromosome DNA have been described which detect structural alterations within or near the genetic locus responsible for the disorder. Both of these cloned segments were described as tightly linked to the locus and were capable of detecting deletions in the DNA of boys affected with DMD. In an attempt to determine more precisely the occurrence of these deletions within a large population of DMD patients and the accuracy of one of the segments, DXS164 (pERT87), in determining the inheritance of the DMD X chromosome, the subclones 1, 8 and 15 were made available to many investigators throughout the world. Here we describe the combined results of more than 20 research laboratories with respect to the occurrence of deletions at the DXS164 locus in DNA samples isolated from patients with DMD and Becker muscular dystrophy (BMD). The results indicate that the DXS164 locus apparently recombines with DMD 5% of the time, but is probably located between independent sites of mutation which yield DMD. The breakpoints of some deletions are delineated within the DXS164 locus, and it is evident that the deletions at the DMD locus are frequent and extremely large.

Chromosome Deletion↗
PubMedDate not supplied

[Grippe and pregnancy. Relation of birth weight to placenta weight].

The different results that have been published concerning the problem of the final outcome for patients who have had influenza during pregnancy reported in numerous works might be explained by differences in methodology used by the different authors. A study was carried out in the Haguenau Maternity Hospital (Bas-Rhin) when an epidemic of influenza occurred in 1972-173. The virological diagnosis was made by carrying out separate serological estimations on 1940 pregnant women. It can be shown that the mean birthweight dropped in infants of mothers who had contracted influenza during pregnancy even when corrections were made for sex and the duration of the pregnancy. The drop in weight of the placenta (37.3 g as a mean) was more obvious and can totally explain the drop in fetal weight. It was not possible to demonstrate any increase in the number of congenital malformations that were found in the neonatal period in the infants born to women who had had influenza. These results suggest that there is no direct passage of the influenza virus across the placenta which, however, is itself modified by the infection.

Animals↗