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M Covic

Publications and source records attributed to M Covic.

At least 19 recordsLinked to original sources
PubMed1978

[Diagnostic and therapeutic problems in a clinical case of oculoauricular dysplasia associated with mandibule-facial dysostosis (Franceschetti-Goldenhar syndrome)].

The authors present a case of oculo-auricular dysplasia (type Goldenhar) associated with France-schetti's syndrome (mandibulo-facial dysostosis) and complicated by paralytic strabismus and genital malformations. Complete investigation failed to establish a precise aetiology; one suggests an external disturbance in the course of the organogenesis of the branchial arches. Aesthetic improvement was undertaken--removal of epibulbar dermoids, correction of the squint, and ablation of the preauricular appendages; functional orthodontic treatment continues.

Adult↗
PubMedDate not supplied

In vivo cytogenetic screening for determination of the mutagenic potential of cyclophosphamide.

Among the in vivo cytogenetic tests employed for chemically induced mutagenicity, a recent screening method was selected - the micronucleus test. The micronuclei were investigated, comparatively with chromosome breaks, on the bone marrow of Wistar rats after intraperitoneal administration of different doses of Cyclophosphamide (CY) applied in one or two injections at 24 hrs interval. The good relationship between these two tests was proved in evaluation of cytogenetic risk.

Animals↗
PubMedDate not supplied

[Hereditary lymphedema (Nonne-Milroy-Meige syndrome) associated with chylothorax. Comments on 2 cases].

This paper presents a family case of brother and sister with unilateral lymphedema, set off spontaneously at prepuberty and earlier in the boy. They both developed a unilateral chylothorax at the age of 22-24. No congenital anomalies are present. The clinical and paraclinical data exclude forms of secondary lymphedema as well as the ones associated with gonadal dysgenesis. The family case history reveals that the parents are not kindred, appear healthy, without pulmonary complaints. Neither no other cases similar to the patients described nor other congenital anomalies or genetic diseases have been recorded in the family. The peculiarity of the cases consists in the fact that lymphedema is confined only to the left lower limb and that there are no modifications in the parents, suggesting an autosomal recessive transmission, which would be a pathogenic novelty. The association with chylothorax points to the importance of a thorough evaluation of the patient with lymphedema of the lower limb.

Adult↗
PubMedDate not supplied

[The incidence of conjugal sterility of endocrine origin].

During a 14-year interval, 27,000 patients were admitted to the Endocrinological Clinic of Iaşi, of whom 337 (207 women and 130 men) for sterility. The endocrine disturbances that may induce sterility are reviewed.

Endocrine System Diseases↗