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Biomedical subjects

M Cozzani

Publications and source records attributed to M Cozzani.

12 recordsLinked to original sources
PubMed2006

Mechanical behavior of an osteotomized mandible with distraction orthodontic devices.

This work analyzes the mechanical behavior of a human mandible when distraction orthodontic devices are used for correcting problems of dental overcrowding and/or arch shrinkage. The mandible 3D model is reconstructed from CT scan data and meshed into finite elements. The distractor is also modeled. FEM analysis included geometric non-linearity. Displacement field of healthy and osteotomized mandibles are compared. Progressive expansion of the distractor and effects of mastication are also analyzed. Finally, we compare two distraction protocols PROT1 and PROT2 where device is, respectively, expanded by 0.6 or 1.2mm/day. The global displacement is 6mm according to clinical recommendations. It came out that mastication forces generate displacements compatible with bone remodeling. However, parasitic rotations of the mandible arms due to mastication may counteract arch expansion induced by the device. Stress concentrations occurred where the device is fixed: stress peaks stay however below yield limit. Finally, PROT2 reduced by about 10% stresses in mandible and reproduces better than PROT1 the displacement field imposed by the device.

Biomechanical Phenomena↗
PubMed2000

A mathematic-geometric model to calculate variation in mandibular arch form.

A mathematic-geometric model was used to evaluate the variation of mandibular dental arch length with respect to the incisor inclination, but without modifying the intercanine width. In analytical terms, the equations of the curves representing the lower dental arch, before and after incisor inclination of 1 mm and of 1 degree, with controlled and uncontrolled tipping, were studied. The length of the mandibular dental arch changed in the parabolic arch form by 1.51 mm for each millimetre of incisor inclination with respect to the occlusal functional plane, by 0.54 mm for each degree of controlled tipping and by 0.43 mm for each degree of uncontrolled tipping. In the elliptical arch form (e = 0.78), it changed by 1.21, 0.43, and 0.34 mm, respectively, in the hyperbolic form by 1.61, 0.57, and 0.46 mm, in the circular form by 1.21, 0.43, and 0.34 mm, and in the catenary form by 2.07, 0.74, and 0.59 mm. The results show that by changing the arch form without modifying the dimension of the dental arch, different arch lengths can be gained for each millimetre of proclination. In addition, by controlled tipping an inter-incisive arch one-fifth longer than by uncontrolled tipping can be obtained. It would be advisable in orthodontic treatment planning to evaluate the type of dental arch, since the space available or the space required changes depending on the arch form and on the orthodontic tooth movement.

Algorithms↗
PubMed1993

Effects of transforming growth factor beta and interleukin-1 beta on expression of cyclooxygenase 1 and 2 and phospholipase A2 mRNA in lung fibroblasts and endothelial cells in culture.

Experiments were conducted to determine the roles of the rate limiting enzymes, cyclooxygenase 1 and 2 (COX1 and COX2) and cytoplasmic phospholipase A2 (PLA2), in transforming growth factor beta (TGF-beta) and interleukin-1 (IL-1 beta) activated prostaglandin synthesis. Results show that TGF-beta increases steady state levels of COX1 mRNA in both human embryo lung fibroblasts (IMR90) and calf pulmonary artery endothelial cells (BPAEC). Temporal experiments show that TGF-beta increases, within 2hrs, a 5.5kb COX1 in IMR90 and the 2.7kb COX1 mRNA in BPAEC. IL-1 beta increases COX1 mRNA only in IMR-90, not BPAEC. COX2 mRNA, under basal conditions, is not detected in BPAEC and is expressed only marginally in IMR90. TGF-beta or IL-1 beta have no effect on expression of COX2 gene in either cell type. IL-1 beta increases steady state levels of PLA2 mRNA in both IMR90 and BPAEC while TGF-beta increases expression of the PLA2 gene only in BPAEC. Time experiments with TGF-beta show induction of PLA2 mRNA within 1hr, peaking at 4hrs. PG synthesis in response to the cytokines was determined in IMR90 and BPAEC to further assess the significance of the above results. TGF-beta increases the synthesis of prostacyclin in BPAEC in a time related fashion peaking at 8hrs at 13 fold above basal. To focus on the action of COX1 and bypass the action of PLA2, exogenous arachidonic acid was used as substrate for PG synthesis. In these experiments IL-1 beta increases PGE2 synthesis 8 fold in IMR90 while IL-1 beta and TGF-beta added simultaneously increases PGE2 synthesis 25 fold. These results in sum illustrate that the cytokines, TGF-beta and IL-1 beta, regulate both COX1 and PLA2 mRNA levels. Furthermore, this regulation appears coordinated to bring about elevation of prostaglandin synthesis.

6-Ketoprostaglandin F1 alpha↗
PubMed1991

Condylar position and maxillary first premolar extraction.

Condylar position in 17 patients whose Class II treatment (14 with edgewise appliances and 3 with Begg appliances) included extraction of the maxillary first premolars and in 17 control patients was compared by means of corrected tomography. The condyles in both groups were in an anterior position, and there were no statistical differences between the groups. In addition, no statistical correlation was found when the posttreatment bite depth, interincisal angle, and maxillary incisor inclination were correlated with condylar position. Thus, as determined in this study, condylar position was unrelated to treatment, bite depth, interincisal angle, and maxillary incisor inclination.

Adolescent↗
PubMed1989

[Carriers of enterotoxic Staphylococcus aureus during a 2 month period in Sienese workers].

From the period of October 1987 to January 1988, 9 samples were taken from 16 workers in company canteens situated in the Sienna area. The study of enterotoxin staphylococci strains was carried out of the pharynx, nose, skin of the face and the hands. The investigation required the use of the Staphylo-Zyme P.B.I. kit and RPLA Oxoid set. The most frequently found enterotoxins were A and D, either alone or together.

Carrier State↗
PubMedDate not supplied

[Bonding of "E"].

When mixed dentition therapy is indicated, the Authors suggest the banding of second deciduous molars to avoid the risk of demineralization of first permanent molars. The method suggested is supported by few clinical cases, shown in the figures, where heavy forces are exerted against the second deciduous molar.

Child↗
PubMedDate not supplied

[Asymmetrical distalization of upper molars with magnets. A clinical case].

The treatment of a patient with an asymmetric malocclusion (class II, division I--subdivision) was presented. The treatment involved the use of repelling magnets for the distalization of the upper right molar which was in a class II relationship. A fixed "Nance" appliance attached to the second premolars was used for anchorage. Magnets are relatively easy to insert, are well tolerated, and they can distalize molars rapidly without significant loss of anchorage. No cooperation was required during the distalization phase of treatment and the second premolar distalized spontaneously once the "Nance" appliance was removed.

Adolescent↗