Biomedical subjects

M Crego-Calama

Publications and source records attributed to M Crego-Calama.

4 recordsLinked to original sources

PubMed2004

Single molecule photobleaching probes the exciton wave function in a multichromophoric system.

The exciton wave function of a trichromophoric system is investigated by means of single molecule spectroscopy at room temperature. Individual trimers exhibit superradiance and loss of vibronic structure in emission spectrum, features proving exciton delocalization. We identify two distinct photodegradation pathways for single trimers upon sequential photobleaching of the chromophores. The rate of each pathway is a measure for the contribution of the separate dyes to the collective excited state of the system, in this way probing the wave function of the delocalized exciton.

Journal Article↗

PubMed2002

Synthesis beyond the molecule.

Weak, noncovalent interactions between molecules control many biological functions. In chemistry, noncovalent interactions are now exploited for the synthesis in solution of large supramolecular aggregates. The aim of these syntheses is not only the creation of a particular structure, but also the introduction of specific chemical functions in these supramolecules.

Binding Sites↗

PubMed2001

Synthetic self-assembled models with biomimetic functions.

Self-assembly can be considered a powerful tool in the hand of chemists for the understanding, modeling and mimicking of biological systems. The possibility of reproducing biological functions in synthetic systems obtained by self-assembly is envisioned as a modest but very important step towards the understanding of the mystery of life and its emergence on Earth.

Allosteric Site↗

PubMed2000

Self-assembly of polar functionalities using noncovalent platforms

Small peptide fragments functionalized with dimelamine units spontaneously form well-defined assemblies. The hydrogen-bond donating and accepting sites in the peptide units are perfectly compatible with the hydrogen-bond assembly motif and slightly stabilize the assembly via additional hydrogen-bond formation.

Journal Article↗