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Biomedical subjects

M Cristea

Publications and source records attributed to M Cristea.

At least 19 recordsLinked to original sources
PubMed1996

RNA amplification for direct detection of mycobacterium tuberculosis in respiratory samples.

A target amplified test system (AMTDT, Gen-Probe, San Diego, California, USA) was compared with conventional standard methods in the detection of Mycobacterium tuberculosis in sputum and other respiratory specimens from patients with suspected tuberculosis. The highest incidence of positive samples was seen with the AMTDT test. Out of 450 samples from patients with known or suspected tuberculosis, 43 (9.6%) were positive by culture, and 47 (10.4%) with AMTDT. After discrepancy analysis, 7 of the culture-negative but AMTDT-positive samples were judged to be true positive, giving the AMTDT a sensitivity of 92.0% and a specificity of 99.8%. The AMTDT test was rapid, easy to perform, sensitive, and highly specific.

Bronchoalveolar Lavage Fluid↗
PubMedDate not supplied

Behaviour of mucopolysaccharides of Kupffer cells in experimental mercury hepatitis.

A reaction of Kupffer cells with changes of mucopolysaccharides is shown during experimental mercury hepatitis. An initial diminution of the reaction intensity is followed by the increase of MPS polymerization degree. Association of effort leads to a significant increase of the A-PAS reaction. The lympho-histiocytes infiltrating portal spaces present the same MPS dynamics.

Animals↗
PubMedDate not supplied

[Some epidemiological indicators in bronchopulmonary cancer in Sector 5 of Bucharest (study of 525 cases)].

The incidence was studied of broncho-pulmonary carcinoma, as well as of other epidemiological indicators in the 5th district of Bucharest over a period of 14 years (1960-1973) during which a total of 525 cases have occured. The incidence in this territory tends to become real from 1967 when the curve overtook the death-rate in the country. Following a continuous increase the number of cases reached 29 0/0000 in 1973 and it is presumed that it will attain 40 0/0000 in 1980. The increase in the morbidity is due to a higher number of cases noted in the extreme age groups (the increase was 2,5-fold in those under 40 years of age); the age group which was the most seriously involved was that between 60 and 69 years, in which the morbidity was of 111 0/0000. The proportion of women has also increased, from 1/6-th to 1/5-th of the total number of cases. In women the frequency of adenocarcinoma and of non-differentiated neoplasies is somewhat higher than in men. The proportion of histopathological confirmation of the disease diminished in the last years probably due to the higher number of aged subjects that cannot be correctly investigated or surgically treated.

Adenocarcinoma↗
PubMedDate not supplied

[Use and evaluation of radiophotography in the ambulatory care of lung diseases].

In the methodological cabinet for pneumology of the Institute of Phtysiology, radiophotography was employed in the following fields: a) screening of acute and chronic pneumopathies as appears from : the increase in the number of cases of non-specific pneumopathies as compared with cases of tuberculosis and the quantitative contribution of the method reflected in the fact that over 80% of the cases with non-specific pneumopathies were detected by radiophotography; b) diagnosis -- by comparing with the data recorded in the files, multiple incidences (front, posterior lordosis, profile); locally pointed (targeted) photographs, rf quantified functional tests in cases suspected of C.O.B.P.: c) follow-up of the evolution of dispensary cases and of the therapeutical effect; d) scientific research and teaching activities through epidemiological and pathogenesis studies, thus allowing for a valorification of the files over a 16 years period. The use of the radiophotographic method in the activity of a cabinet of pneumology is necessary especially because it allows for an early detection, a superior morphological diagnosis, as compared with radioscopy (fluoroscopy), for an objective and economical follow-up of the cases, providing at the same time material for scientific research and teaching demonstrations.

Ambulatory Care↗
PubMedDate not supplied

[Retrospective study of the value of radiophotographic examinations in the detection of pulmonary cancer].

Out of a total of 123 cases of centro-hilar pulmonary carcinoma and of 65 cases of carcinoma with peripheral localization changes on the previous radiophotographic images were found in 54% of the cases. The time necessary for doubling of the tumour size was of 22 months for the peripheral forms of cancer. The suspicion of pulmonary cancer was mentioned in the radiophotographic register two years before the diagnosis of the disease was made.

Humans↗