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Biomedical subjects

M Csató

Publications and source records attributed to M Csató.

At least 19 recordsLinked to original sources
PubMed1989

[The irritant effect of dithranol using capillary resistance measurement].

The effect of topically applied dithranol on the capillary resistance (CR) was studied both in healthy volunteers and in clinically unaffected skin of psoriatic patients. The CR of the psoriatic patients was significantly lower than that of the healthy persons. O.10% and 0.25% dithranol ointment induced a significant decrease of CR in the skin of both groups. This decrease was prevented or at least reduced, if the patients had previously been treated with either the antihistamine clemastine or the cyclooxygenase-inhibitor indomethacin. The effect of dithranol on the CR was also moderated, if 5% coal tar had been added to the dithranol preparation.

Adult↗
PubMed1989

Pharmacological studies on dithranol-induced irritative dermatitis in mice.

The effects of different pharmacological substances on dithranol-induced irritative dermatitis were studied in mice. Pretreatment of the animals with a specific platelet activating factor (PAF) antagonist, BN 52021, significantly reduced the ear swelling in a dose-dependent manner. The cyclooxygenase inhibitor indomethacin, the antihistamine clemastine, and the anti-oxidant superoxide dismutase also proved to be effective in the reduction of the dermatitis. The results provide evidence of the coinvolvement of PAF, prostaglandins, histamine, and reactive oxygen radicals in dithranol-induced irritative dermatitis in mice.

Animals↗
PubMed1984

The effect of mouse erythrocyte rosette forming lymphocytes on lymphokine production in T-cell cultures.

An enhancement effect of mouse erythrocyte rosette forming (MERF) cells on the production of migration inhibitory factor, chemotactic factor for neutrophils and skin reactive factor in T-lymphocyte cultures stimulated with the purified protein derivative of tuberculin was observed. We consider it likely that the MERF cells, possessing the appropriate cell surface constituents to construct an immunogenic moiety, present antigen on their surfaces to elicit lymphokine production.

Animals↗
PubMed1984

Increased IgG Fc and C3 rosette-forming capacity of granulocytes from patients with psoriasis.

In the present work the proportions of IgG Fc and C3 rosette-forming granulocytes were studied in patients with severe psoriasis. The percentages of erythrocyte-antibody and C3 rosette-forming granulocytes from psoriasis patients were significantly higher than those of healthy individuals. Sera from patients with psoriasis did not influence the rosette formation by granulocytes from healthy persons. The increased IgG Fc and C3 receptor activities of granulocytes in psoriasis may account for the hyperactivity of these cells enhancing the susceptibility of the polymorphonuclears for at least some naturally occurring stimuli.

Adult↗
PubMed1983

[Nitroblue tetrazolium reduction activity of circulating and skin-migrating leukocytes in psoriasis].

The nitroblue tetrazolium (NBT) reductive activity of polymorphonuclear leucocytes separated from the circulation as well as that of leucocytes migrating into the skin collected by skin chamber technique was studied with a quantitative method in patients with psoriasis vulgaris and in healthy persons. The NBT reductive activity of the leucocytes migrated into the skin was significantly higher in the healthy persons and slightly but not significantly elevated in psoriasis when compared with the cells separated from the blood. The dye reduction by the circulating cells was enhanced in psoriasis. On the other hand, in psoriasis the NBT reduction by the migrating cells did not differ from that of the leucocytes in healthy persons. The most likely explanation for the lack of the enhancement of activation during migration into the skin in psoriasis is that the polymorphonuclear leucocytes are already present in the circulation in hyperactive state.

Adult↗
PubMed1983

Transfusion therapy for erythropoietic protoporphyria.

Five patients with erythropoietic protoporphyria, in whom beta-carotene treatment had proved unsuccessful, were treated on 5 or 6 occasions with washed, packed red blood cell transfusions. Following the transfusions, the photosensitivity and the protoporphyrin levels in the red blood cells decreased considerably. This treatment may be useful in reducing the high protoporphyrin level in patients with a rapidly deteriorating hepatic function.

Blood Transfusion↗
PubMed1982

Regulation of lymphokine production in peripheral blood mononuclear cell cultures.

An increase in the production of macrophage migration inhibitory factor, chemotactic factor for neutrophils, and skin reactive factor, was observed in lymphocyte cultures if the cells were allowed to age in culture for 24 h. The increased lymphokine production was reduced by adding concanavalin A-stimulated and mitomycin C-treated suppressor cells. It is suggested that the lymphokine production could be regulated by suppressive mononuclear cells.

Cells, Cultured↗