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M Cuenca-Estrella

Publications and source records attributed to M Cuenca-Estrella.

45 records · Page 3Linked to original sources
PubMed1996

Changes in susceptibility of Salmonella enteritidis, Salmonella typhimurium, and Salmonella virchow to six antimicrobial agents in a Spanish hospital, 1980-1994.

To determine changes in the susceptibility patterns of Salmonella enteritidis, Salmonella typhimurium, and Salmonella virchow over time, resistance to ampicillin, chloramphenicol, tetracycline, gentamicin, trimethoprim/sulfamethoxazole, and nalidixic acid was studied by the disk diffusion method in 1,024, 191, and 61 clinical isolates of these organisms, respectively. All isolates were recovered from 1980 to 1994 at a hospital in Madrid, Spain. Salmonella enteritidis isolates were less resistant (10.9%) than Salmonella typhimurium (43.5%) and Salmonella virchow (36.1%; p < 0.001). The incidence of resistance of Salmonella enteritidis to ampicillin increased from 2.7% during the period 1980-1982 to 15.6% during 1992-1994 (p < 0.001). The resistance of Salmonella typhimurium to ampicillin, chloramphenicol, and tetracycline increased from 15.2%, 7.6%, and 21.2% respectively in 1980-1982 to 73.3%, 46.7%, and 73.3% in 1992-1994 (p < 0.001). These marked increases in antimicrobial resistance suggest the need for public health interventions, several of which are discussed.

Anti-Bacterial Agents↗
PubMed1995

[Soft-tissue infection caused by Aeromonas hydrophila].

BACKGROUND: Two cases of soft tissue infection by Aeromonas hydrophila are presented with review of the literature. PATIENTS AND METHODS: Two cases of soft tissue infection by Aeromonas hydrophila diagnosed from 1992-1993 are reported. RESULTS: Most soft tissue infection produced by Aeromonas organisms are caused by Aeromonas hydrophila. These infections predominantly affect the lower limbs of middle-aged males with previous history of injury favoring infection. The most common clinical presentation is cellulitis with a good prognosis if bacteremia is not produced. Antibiotics, such as mainly third generation cephalosporins, imipenem, aztreonam, cotrimoxazole, tetracycline, chloramphenicol, quinolones and aminoglucosides (except streptomycin) are usually very active in vitro against these organisms. Surgery is often necessary to cure the process. CONCLUSIONS: Cellulitis by Aeromonas hydrophila is a very infrequent entity in Spain and is usually associated to previous injury and probable contamination by environmental bacteria.

Adult↗
PubMedDate not supplied

[Infection and colonization by Scedosporium prolificans].

BACKGROUND: Scedosporium prolificans is a dematiaceous fungus that is known to cause a wide spectrum of infections in humans, bearing a severity and a prognosis that is relationed with the patients immune status. METHODS: A retrospective review was made of the clinical charts of all patients who developed positive S. prolificans cultures in our centre from 1990 to 2000. Isolates were identified by colonial morphology and microscopic features. The in vitro susceptibility was evaluated using the microdilution method according to NCCLS. RESULTS: S. prolificans was isolated in 15 patients. Eight were affected with cystic fibrosis and the isolation of S. prolificans in their airways did not worsen their clinical status. Among the remaining 7 cases there were five leukemic patients with neutropenia and two immunocompetent hosts with cutaneous infection and endocarditis. Four of five neutropenic patients died of sudden sepsis and S. prolificans was isolated from blood cultures made a few days before their death, and the fifth neutropenic case suffered a bilateral pneumonia with improving course probably due to recovery from neutropenia. As to the immunocompetent group the clinical course was good in the cutaneous infection case, but the endocarditis case died four days after the antifungical therapy was started. All the isolates tested were found to be resistant to amphotericin, 5 flucytosine, fluconazole, itraconazole, voriconazole, miconazole and terbinafine. CONCLUSIONS: Scedosporium prolificans is a fungal pathogen that colonizes the airways of patients affected with cystic fibrosis. It can also cause a wide variety of infections, whose severity and prognosis depends on the patients immune status. Due to the resistance of this fungus to antifungal drugs, the therapeutic options are limited. Only with the correction of neutropenia and surgery in local infections in immunocompetent hosts it has been possible to cure these infections.

Acute Disease↗
PubMedDate not supplied

[Epidemiological profile of non-typhi salmonellosis in a hospital in urban Madrid (1980-1994)].

BACKGROUND: The aim of this study was to describe the epidemiologic profile of non-typhoid salmonellosis at a general hospital in the metropolitan area of Madrid. METHODS: A descriptive and retrospective study of non-typhoid salmonellosis diagnosed at Microbiology Department of Fundación Jiménez Díaz from May 1980 to December 1994 was done. RESULTS: Non-typhoid Salmonella (NTS) was identified in 1796 specimens of 1463 patients, 520 (35.5%) were under 15 years and 943 (64.5%) were over 14 years. The infection was intestinal in 1288 (88%) cases, bacteremic in 129 (8.8%) and focal in 46 (3.1%). The extraintestinal infection was most frequent in patients over 14 years (15.5% versus 5.6%; p < 0.001). From 1987, 34 adults patients with human immunodeficiency virus (HIV) infection developed salmonellosis. The infection was due to Salmonella serogroup B (29.4%) and the extraintestinal manifestations (58.8%) were most frequent in HIV-infected patients than in the control-group (p = 0.004 and p < 0.001, respectively). Salmonella serogroup D was identified in 1041 (71.2%) episodes, and serogroup B in 259 (17.7%). Salmonella serogroup B and C were more resistant to one or more antibiotics than Salmonella serogroup D (p = 0.001). Resistance of NTS (principally Salmonella serogroup B) for one or more antibiotics (particularly ampicillin and chloramphenicol) increased significantly during the period of study (p < 0.001). CONCLUSIONS: The HIV-infected patients had a predisposition to develop extraintestinal Salmonella infections. Resistance of NTS for antibiotics, especially Salmonella serogroup B, has significantly increased during the last years.

Adolescent↗