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Biomedical subjects

M Cusini

Publications and source records attributed to M Cusini.

At least 37 records · Page 2Linked to original sources
PubMed1995

Role of radiotherapy in the treatment of epidemic Kaposi's sarcoma: experience with sixty-five cases.

BACKGROUND: Treatment of Kaposi's sarcoma (KS) associated with HIV infection should improve often disfiguring lesions, with an acceptable cosmetic outcome; relieve associated signs and symptoms (pain and edema); and have no adverse effects on the patient's already impaired immune status. OBJECTIVE: Our purpose was to determine the role of x-ray therapy in the treatment of KS. METHODS: Contact x-ray therapy and half-deep x-ray therapy were used to treat 594 lesions in 65 patients with KS, who were observed for 1 to 43 months (mean, 9 months). RESULTS: Complete remission was achieved with pigmentation in 405 lesions (68.3%), with good cosmetic results in 105 (17.7%), and with hypopigmentation in three (0.5%). In 80 lesions (13.5%) only size reduction or pain palliation were achieved. Fourteen lesions (2.4%) relapsed 2 to 9 months after treatment. CONCLUSION: X-ray therapy is well tolerated and meets the specified requirements for the treatment of KS.

Adult↗
PubMed1992

Non-pathogenic entamoeba histolytica in Italian HIV-infected homosexuals.

A cohort of 51 homosexuals who were either HIV-positive or had AIDS was followed prospectively with parasitologic stool examination and in vitro culture in order to determine the incidence of E. histolytica infection. Amoebic isolates were further characterized by electrophoretic isoenzyme study. Five subjects (9.8%) were found to be infected with E. histolytica. None of the amoebic isolates were found to be pathogenic by isoenzyme analysis.

Acquired Immunodeficiency Syndrome↗
PubMed1991

Acyclovir resistance/susceptibility in herpes simplex virus type 2 sequential isolates from an AIDS patient.

The biological characterization of a number of sequential herpes simplex virus type 2 (HSV-2) isolates obtained from an AIDS patient undergoing sequential courses of antiviral treatment due to an extended mucocutaneous genital lesion is reported. Resistance to acyclovir (ACV) and related compounds was linked to a thymidine kinase-deficient (TK-) phenotype. After ACV discontinuation and a course of treatment with foscarnet, a new isolate was recovered, characterized by loss of the ACV-resistant trait and production of a functional TK enzyme. Data presented stress the need for monitoring chemosensitivity of HSV isolates in AIDS patients while suggesting that for better control of the infection, these patients should benefit from alternative treatments with drugs aimed at different viral targets.

Acquired Immunodeficiency Syndrome↗
PubMed1990

Oral hairy leukoplakia.

Oral hairy leukoplakia was first described in homosexual men infected with the human immunodeficiency virus. It is thought to be caused by infection with both the Epstein-Barr virus and human papillomavirus. We report 59 cases of oral hairy leukoplakia. The disease was diagnosed in patients in all risk groups and was categorized in all classes of the Walter Reed classification without significant differences in prevalence. Epstein-Barr virus could be demonstrated in all tissue samples examined; human papillomavirus was found in only a few specimens. In our series oral hairy leukoplakia had a chronic course, although temporary spontaneous healing occurred in some cases. Its appearance was a poor prognostic sign because acquired immunodeficiency syndrome developed in a significant proportion of patients within a few months of onset.

Acquired Immunodeficiency Syndrome↗
PubMed1990

[Results of radiotherapy in 22 patients with epidemic Kaposi's sarcoma].

Radiotherapy is a first choice treatment of skin and oral cavity lesions of epidemic Kaposi sarcoma. It has cosmetic aims in the early stages of the disease, and palliative ones to reduce soreness and associated oedema in the lesions of a more advanced disease. This treatment modality has few side effects and does not modify the immunological condition of the patients. These statements, as they result from the review of the related literature, are here assessed by the experience of the Authors in a series of 22 patients, treated by means of orthovoltage radiotherapy, which allows intracavitary treatments (contact X-ray therapy) and small-sized irradiation fields.

Acquired Immunodeficiency Syndrome↗
PubMed1988

Mucocutaneous manifestations in patients infected with human immunodeficiency virus.

The mucocutaneous manifestations observed in 516 patients infected with human immunodeficiency virus attending an outpatient clinic for acquired immunodeficiency syndrome in Milan, Italy, from July 1985 to March 1987 are listed, and the clinicopathologic aspects of these disorders are reported. The prognostic significance of some human immunodeficiency virus-associated dermatoses is also discussed.

Acquired Immunodeficiency Syndrome↗
PubMed1988

Atypical early syphilis in an hiv-infected homosexual male.

A homosexual male, seropositive to HIV and with previously documented syphilitic infections, developed a slowly growing nodule on his left wrist (possibly a chancre) followed, after 2 months, by a few scattered, large papular lesions. Serological evidence of active syphilis was obtained and treponema were identified in the initial lesion by means of immunofluorescent staining. Treatment with both aqueous crystalline penicillin G and benzathine penicillin G healed the lesions. This represents a further case of an atypical presentation of early syphilis in an immunocompromised host.

Acquired Immunodeficiency Syndrome↗
PubMed1985

Heterogeneity of dermal OKT6+ cells in inflammatory and neoplastic skin diseases.

This immunopathologic study of both normal and pathologic skin specimens (contact dermatitis [CD], lichen planus [LP], cutaneous T cells lymphoma [CTCL], and histiocytosis X [HX]) allowed as to differentiate four types of dermal OKT6+ cells: (1) cells with the same morphologic features as epidermal Langerhans cells (LCs), rarely found in either normal or pathologic dermis; (2) cells structurally similar to LCs but lacking Birbeck granules (BGs), found mainly in CD and LP; (3) larger cells rich in cytoplasmic organelles, only 5% of which contained BGs. They were especially common CTCL; and (4) cells typical of HX.

Adult↗