Biomedical subjects

M Cvjetković-Bosnjak

Publications and source records attributed to M Cvjetković-Bosnjak.

4 recordsLinked to original sources

PubMed1995

[Clinical characteristics of depressive disorders].

In this article authors investigated the clinical distinction between endogenous and neurotic depression. The endogenous depression was equivalent to severe depressive episode without psychotic symptoms, according to ICD-X criteria, and neurotic depression was equivalent to dysthymia. The results showed that endogenous depressive patients were much older than neurotic depressives, and that they had more severe symptoms of depression. On the other hand endogenous depressive patients responded better to antidepressive therapy, and consequently they had better prognosis than neurotic depressive patients.

Adolescent↗

PubMedDate not supplied

[Comparison of the efficacy of traditional antidepressive agents and the new generation of antidepressives in the treatment of depressive disorders].

INTRODUCTION: Considerable efforts have been made throughout the last 20 years to develop drugs that can replace tricyclic antidepressants as the primary treatment for depression. These efforts are well justified since tricyclic antidepressants, although therapeutically quite efficient, cause several problems, such as side effects and toxicity at therapeutic doses, causing particular problems in the elderly and in patients with congestive heart disease, and giving severe toxicity when taken in overdose. A number of compounds that are pharmacodynamically different from the tricyclics have been developed, and Selective Serotonin Reuptake Inhibitors are such. This group of antidepressives has been developed and widely marked as antidepressant therapy which offers safety and tolerability advantages over tricyclics. Tricyclic antidepressants have been the standard drug treatment for depressive illness, against which the efficacy of new compounds is compared in this investigation. MATERIAL AND METHODS: 30 female inpatients were examined. All patients had to fulfill the inclusion criteria for moderate depressive disorders, according to International Classification of Diseases. The primary efficacy parameters in the study were the changes from baseline Hamilton Rating Scale for Depression with 19 items, total score at endpoint. Patients were evaluated weekly for efficacy and adverse events. Clinicians also rated patients on the Hamilton Rating Scale for Anxiety. In statistical analysis X and T test were used. RESULTS: There was no significant difference between two groups of patients in response to tricyclic antidepressants and selective serotonin reuptake inhibitors. Selective Serotonin Reuptake Inhibitors show less adverse effects compared to tricyclics, so they appeared to be better tolerated. CONCLUSION: The traditional and new antidepressive drugs appeared to be equally effective in the treatment of moderate depressive disorders, but new drugs: Selective Serotonin Reuptake Inhibitors show less adverse effects, compared to the traditional, tricyclic antidepressants.

Adolescent↗

PubMedDate not supplied

[Depression in older persons].

INTRODUCTION: Depression is a common problem in old age, especially among those with various medical illnesses. Aging brings about numerous losses that might lead to depression: loss of health, loved ones and social roles. Some of older persons develop depression. Depression in old age is a serious illness. The suicide rate among older persons is very high. Approximately 90% of elderly people who commit suicide suffer from depression. Adequate treatment of depression in late life includes reducing and resolving depressive symptoms, preventing its relapse and reoccurrence, improving quality of life, and reducing mortality and healthcare costs. MATERIAL AND METHODS: 32 female inpatients were examined. All patients suffered from depressive disorder (middle, according to International Classification of Diseases (ICD-X). Only patients without cognitive impairment were included in the study, according to Mini-Mental State Examination. Hamilton Rating Scale for Depression was used as primary measure of efficacy. Patients were evaluated for efficacy weekly. For statistical analysis t test was used. RESULTS: Depressive disorders are more severe among older patients, with greater suicidal risk, anxiety and psychomotor agitation. Patients treated with moclobemide show quicker remission of depressive symptoms compared to patients who were treated with mianserin. CONCLUSION: Depressive disorders among older patient are very serious illnesses, but with adequate therapy, symptoms can disappear, and there is no difference between remission in depression among older and younger patients.

Adult↗

PubMedDate not supplied

[Clinical characteristics of unipolar and bipolar depression].

INTRODUCTION: In the last decades affective disorders were divided into unipolar and bipolar and this division has been generally accepted. The bipolar type is manifested by mania or by both mania and depression. On the other hand, unipolar affective disorders are manifested only by depression. In numerous investigations authors have noticed that there are very distinctive differences between these two types of depressive disorders such as: course of illness, personality disorders, sex, family history etc. Nevertheless, in practice it is often very difficult to make the right diagnosis. The bipolar type often starts with a few pure depressive episodes and sometimes mania occurs a few years later so only at that point the psychiatrist can make the right diagnosis and treat the patient correctly. MATERIAL AND METHODS: This investigation comprised 50 patients hospitalized at the Psychiatric Clinic in Novi Sad during 1992-1995. The experimental group consisted of 20 patients with a bipolar affective disorder (according to ICD-X), while the control group consisted of 30 patients with clinical diagnosis of unipolar depression (intensive, without psychiatric features). Both groups of patients were weekly evaluated by Hamilton Depression Rating Scale (HDRS), whereas the initial score for all patients had to be higher than 16. RESULTS: Patients suffering from unipolar depression were older than patients with bipolar depression and there were more females in this group. There were no differences in demographic characteristics (level of education, migration, etc.), but the experimental group had a greater genetic loading for affective disorders. Unipolar depressive patients had more agitation and they were more anxious than patients with bipolar depression. DISCUSSION AND CONCLUSION: The fact that unipolar depressive patients were older than bipolar is similar to most of the results gained in this kind of investigation. On the other hand, we did not find statistical differences in the intensity of disorders, and in the literature these results are contraindicating. Numerous investigators report that bipolar depressives had a stronger genetic loading for affective disorders and our study confirms the same. All these results can help us to make the right diagnosis of unipolar and bipolar affective disorders.

Adolescent↗