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M Czarkowski

Publications and source records attributed to M Czarkowski.

16 recordsLinked to original sources
PubMed2005

Is the resistance of large conduit arteries also decreased in thyrotoxic patients with Graves' disease?

Longitudinal arterial resistance (RL) originates during blood flow in large conduit arteries while peripheral resistance (RP) reflects the tension of arterioles. Using a new noninvasive ultrasonic system of assessment of mechanical properties of arterial walls, we aimed to discover whether both RL and RP are affected by excess of thyroid hormones (TH). We compared two groups: hyperthyroid (Graves' group, n = 25) and euthyroid (control group, n = 23). RL and RP values were obtained from the analysis of the four-element lumped parameters model describing the vascular input impedance. The vascular input impedance was determined on the basis of simultaneous measurements of blood pressure, blood flow and arterial diameter using oscillometric and ultrasonic methods. RL and RP were lower in the Graves' group (3.71 +/- 1.98 versus 4.49 +/- 1.81 10(8)kgm(4)s(1), p < 0.05 and 8.43 +/- 3.56 versus 11.23 +/- 2.69 0(8)kgm(4)s(1), p < 0.00002, respectively). There was strong correlation between RP and TH in the Graves' group (r(s)= -0.6710, p = 0.000001 for RP and free triiodothyronine (FT3); r(s)= -0.4683, p < 0.001 for RP and free thyroxine [FT4]). This relationship remained significant after the statistical correction for total cholesterol (r(p)= -0.7064 p = 0.0000001 for RP and FT3). No similar correlation between RL and TH was found what suggests a different character of relations between TH and RL and between TH and RP.

Adolescent↗
PubMed2002

The stiffness of the common carotid artery in patients with Graves' disease.

BACKGROUND: Thyroid hormone excess is accompanied by many cardiovascular symptoms. We hypothesised that mechanical properties of the large arteries are also involved in hyperthyroidism-induced cardiovascular changes and set out to investigate this further. METHODS: We compared 2 groups: one composed of hospitalized patients with newly diagnosed, non-treated Graves' disease (Graves' group) and the other (control group) composed of healthy persons or patients with euthyroid goiter (n=25 and n=23, respectively). We determined values of cross-sectional compliance (CC(100)), distensibility (DC(100)) and stiffness coefficients (alpha(100)) estimated for blood pressure P(n)=100 mmHg by measuring the blood pressure with the oscillometric method and measuring differences in the diameter of the common carotid artery with ultrasonographic vascular echo Doppler system. RESULTS: We found no differences in CC(100) (10.6 vs 10.3 10(-4)m(2)/Mpa), DC(100) (29.7 vs 29.6 1/Mpa) or alpha(100) (2.67 vs 2.72) between the 2 groups. However, there were strong correlations between all stiffness parameters and plasma thyroid hormone concentrations in the Graves' group (r(s)=0.4698, p<0.001 for DC(100), r(s)=0.4342, p<0.003 for CC(100), r(s)=-0.4698, p<0.001 for alpha(100) and fT3, respectively). This relationships remained significant after statistical corrections for age and lipid levels (r(p)=0.22, p<0.03 for DC(100) and fT3 or r(p)=-0.457, p<0.02 for alpha(100) and fT3, respectively). CONCLUSIONS: These results indicate that in the Graves' group the stiffness of the common carotid artery might be affected by the thyroid hormone level and the lower the level, the more severe the activity of the hyperthyroidism reflected by the plasma concentration of fT3 or fT4.

Adult↗
PubMed1993

[Young men with a positive family history of hypertension have higher values in a circadian blood pressure profile].

Non-invasive automatic 24-h indirect monitoring of blood pressure was performed in two groups of young males - group S - 55 men with positive family history of essential hypertension (EH) (mean age 24.6 +/- 3.6 years) and group K - 11 men with negative family history of EH (23.5 +/- 3.7 years). Circadian blood pressure variations were studied in two-hour periods throughout 24 hours. The curves of the blood pressure profiles in groups S and K had similar shape. The mean systolic blood pressure estimated for each of the two-hour periods was higher in group S than in group K in the corresponding period. Mean diastolic blood pressure estimated for each of the two-hour periods was higher in group S than in group K in almost all periods of the daily activity. These results indicate that young males with positive family history of EH have higher blood pressure than young males with negative family history of EH. This stable disregulation of blood pressure is present not only during day-time activity but also during sleep.

Adult↗
PubMed1993

[Augmented activity of the adrenal medulla in young men with positive family history of essential hypertension].

Serum adrenaline (AD) and noradrenaline (NA) were measured by RIA method in two groups of young males: group S (n = 54) with positive family history of essential hypertension (EH) and group K (n = 9) with negative family history of EH (mean age: 24.6 +/- 3.3 i 23.6 +/- 3.6 years respectively). AD and NA concentrations were estimated in basic conditions (AD1, NA1) and after 10 min of passive vertical posture(AD2, NA2). In group S AD1 concentration was higher than in group K (54.4 +/- 24.4 i 37.8 +/- 15.6 pg/ml respectively, p < 0.05). In group S a positive correlation was found between mean systolic blood pressure (SBP) and mean heart rate (HR) estimated during 5-hours monitoring by Spacelab IGR 5300 ambulatory blood pressure and heart rate monitoring system (r = 0.5, p < or = 0.01). Pearson's correlation coefficient (Pcc). In this same group positive correlations were also found between AD2 and SBP - r = 0.31, p < 0.05 (Pcc) and between AD2 and HR: r = 0.33, p < 0.05 (Pcc). Results of 5-hours blood pressure monitoring showed that 15 of 54 males from group S had SBP > 139 mmHg (group S1). In group S1, AD1 and AD2 concentrations were higher than in group K (AD1: 366 +/- 144; 206 +/- 85, p < 0.01 and AD2: 626 +/- 266; 369 +/- 156 fmol/ml, p < 0.05 respectively). No differences were found in AD1, AD2, NA1 and NA2 concentration between group K and normotensive (SBB < 140 mmHg) males with positive family history of EH: group S2. In young males with positive family history of EH, the elevation of blood pressure might be caused by an augmented activity of the adrenal medulla.

Adrenal Medulla↗
PubMed1992

[Effect of hemodialysis on the level of serum digoxin-like substance and sodium-potassium pump activity in erythrocytes from patients with chronic renal failure].

Digoxin-like immunoreactivity (DLS) and erythrocyte sodium-potassium pump (PSP) activity were measured in a group of 16 patients with chronic renal failure (CRF) before and just after haemodialysis and in a group of 9 healthy persons. Before haemodialysis DLS was present in the blood of most CRF patients, at the mean concentration of 0,14 +/- 0,13 micrograms/l. After haemodialysis DLS concentration decreased to 0,09 +/- 0,09 microgram/l (p less than 0,01). In the control group blood DLS concentration was nondetectable. In the CRF group PSP activity was higher before than after haemodialysis (p less than 0,01; 12,1 +/- 1,8 and 7,6 +/- 1,4 muMol Pi/h/g Hb. PSP activity in the control groups was 10,3 +/- 1,9 muMol Pi/h/g Hb). In the CRF group PSP activity was higher before haemodialysis (p less than 0,05) and lower after haemodialysis (p less than 0.01) than in the control group. Our results confirmed the presence of DLS in the blood of the majority of CRF patients. DLS concentration decreased after haemodialysis but we did not found any parallel increase in PSP activity in these patients. These results did not confirm the hypothesis that DLS might inhibit PSP activity in red blood cells from CRF patients.

Adult↗
PubMed1991

[Activity of the sodium-potassium pump and values of sodium and potassium in erythrocytes in patients with non-dialyzed renal failure and arterial hypertension treated conservatively].

In 8 non-dialysed patients with chronic renal failure (PNN) and hypertension (NT)-(PNNT group) sodium-potassium pump activity (PSP) and intra-erythrocyte sodium (NaE) and potassium (KE) concentration were measured. No differences were found in PSP, NaE and KE between group PNNT and healthy volunteers (Z). These results do not support an importance of the role of the so-called endogenous PSP inhibitor in the pathogenesis of NT in patients with PNN.

Adult↗
PubMedDate not supplied

[Blood level of free serotonin, catecholamines and the renin-angiotensin-aldosterone system in patients with primary hypertension].

Two subgroups of patients were selected out of those dialysed for chronic renal failure. Group A included patients without arterial hypertension before dialysis, and group B patients with arterial hypertension before dialysis. Blood endogenous digoxin-like substance (DLS) has been assayed. Its blood levels were not increased in hypertensive patients either before or after dialysis. No correlation was found between DLS and mean arterial pressure in the whole group of patients with chronic renal failure. The obtained results do not suggest that arterial blood pressure in patients with chronic renal failure is related to the presence of DLS in the blood.

Adult↗
PubMedDate not supplied

[Blood pressure in young men with a family history of primary hypertension--traditional and 24-hour blood pressure measurements].

Blood pressure was measured in two groups of young males-group S-55 men with positive family history of essential hypertension (EH) and group K-11 men with negative family history of EH (mean age 24.5 +/- 3.3 and 23.5 +/- 4.7 years). Two methods of blood pressure measurement--traditional blood pressure measurement (method A) and automatic ambulatory indirect blood pressure monitoring (method B) were used. Blood pressure was higher in group S than in group K-method A 140 +/- 14/86 +/- 10 vs 122 +/- 10/73 +/- 8 mm Hg; method B: 132 +/- 11/78 +/- 10 vs 123 +/- 8/72 +/- 7 mm Hg. Contrary to group K, in group S discrepancies in the frequency of diagnosis of systolic or diastolic hypertension were found between the two methods of blood pressure measurement. These results indicate that in young males the traditional method of blood pressure measurement may provide a false positive diagnosis of hypertension, but both methods of blood pressure measurement used in this work were effective in the diagnosis of normotension. As a population the young males with positive family history of EH have higher blood pressure then young males with negative family history of EH.

Adult↗
PubMedDate not supplied

[Isometric exercise and cold pressor test in young men with a family history of essential hypertension].

An exaggerated pressor reaction to the isometric exercise and cold pressor test (CPT) is found to be a predictor or future hypertension. In the two groups of young males: 51 men with positive family history of essential hypertension (EH) (mean age: 24.3 +/- 3.3 years, group S) and 11 men with negative history of EH (mean age: 23.5 +/- 3.7 years, group K) the blood pressure responsiveness to the handgrip test (HG) and CPT were evaluated. Ambulatory systolic (SBP) and diastolic (DBP) blood pressure were higher in S then K (respectively: 136 +/- 11/81 +/- 10 mm Hg vs 126 +/- 4/76 +/- 6 mm Hg, p < 0.05). The elevation of blood pressure after HG (30% of maximal voluntary contraction for 3 min.) was higher in K than S (respectively: delta SBP = 37 +/- 20 vs 21 +/- 17 mm Hg i delta DBP = 27 +/- 20 vs 7 +/- 12 mm Hg, p < 0.05). Similarly, after CPT (by immersing the left hand and forearm in ice-cold water for 2 min.) the elevation of blood pressure was higher in K than S (respectively: delta SBP = 22 +/- 11 vs 12 +/- 12 mm Hg i delta DBP = 17 +/- 12 vs 9 +/- 9 mm Hg, p < 0.05). These results do not confirm an exaggerated blood pressure responsiveness to the HG test or CPT in young males with positive family history of EH, irrespectively to the diagnosis of normotension or borderline hypertension.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗