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Biomedical subjects

M D Aleĭnik

Publications and source records attributed to M D Aleĭnik.

At least 19 recordsLinked to original sources
PubMed1992

[The role of the food transmission factor in the occurrence of 2 hepatitis A outbreaks].

Two outbreaks of virus hepatitis were etiologically and epidemiologically interpreted. In this work the original method of obtaining washings, with their subsequent concentration, from the suspected foodstuff was used and hepatitis A virus was then detected in concentrated washings in the enzyme immunoassay, which made it possible to confirm the contribution of the alimentary factor of the transfer of infection (sun-cured melon) in the above-mentioned outbreaks. The data thus obtained are indicative of the necessity to conduct epidemiological investigation, taking into account the possibility of contacting hepatitis A when using foodstuffs not subjected to preliminary treatment.

Age Factors↗
PubMed1991

[The characteristics of using short-term prediction methods with viral hepatitis morbidity in small areas].

The results of the approbation of the method of using the regressive equation for the short-term prognostication of viral hepatitis morbidity in limited areas (a region or a city). The specific features of the epidemic process, characteristic of limited areas, have been considered. These findings serve as the basis for proposing some methods of prognostication within the limits of an individual region or city, thus making it possible to improve the orientation of prophylactic measures aimed at decreasing viral hepatitis A morbidity.

Disease Outbreaks↗
PubMed1990

[The epidemiological patterns of hepatitis non-A, non-B].

The etiological structure of viral hepatitides in three cities of the Volga region was studied. The proportion of hepatitis non A, non B was established: it varied from 3.6% to 18.1% at different territories and depended on the total morbidity level, on the season, as well as on the age of patients. A suggestion was made concerning the role of the parenteral mechanism of the transfer of hepatitis non A, non B at the territory under study.

Age Factors↗
PubMed1990

[A trial to decrease hepatitis A morbidity in Dzerzhinsk, Gorki Province].

The results of experience in the comparative evaluation of the preseasonal immunoglobulin prophylaxis in two towns of the Gorki Province are presented. The work substantiates the economic and epidemiological effectiveness of immunoglobulin prophylaxis at the territory, relatively safe with respect to hepatitis A, under the conditions of its realization in the year of the predicted rise of morbidity, the timely organization of immunoglobulin prophylaxis (from July to the first half of October) and the coverage of "organized" children, exceeding 90%.

Child↗
PubMed1988

[Late observations in a familial foci of hepatitis B using a full set of specific markers of the infection].

The complete set of specific markers of hepatitis B has been identified, thus making it possible to evaluate the spread of this infection in family foci, as well as the intensity and dynamics of the epidemic process, under the conditions of prolonged observations. The study has shown that the spread of hepatitis B infection is determined by the presence of HBeAg in antigen-positive patients with viral hepatitis B and HBsAg carriers.

Biomarkers↗
PubMed1987

[Etiological structure of viral hepatitis in the area about one of the cities in Gorki Province].

The etiological structure of viral hepatitides (VH) in one of the towns of the Gorky region was studied with the use of specific methods for diagnosing hepatitis A (detection of IgM to hepatitis A virus) and hepatitis B (detection of HBsAg in the passive hemagglutination test). The study revealed that hepatitis A was the major nosological from in the structure of VH among children and adults in the area under survey, which was documented by the detection of IgM to hepatitis A virus. The form, second in importance among VH cases, was hepatitis B. The ratio of these two forms of VH was determined by the epidemiological situation in the area. The proportion of hepatitis B cases increased at the period between epidemics. Nondifferentiated hepatitis constituted 6.8% of all cases of sporadic hepatitis among adults. In 90% of cases clinical diagnosis coincided with the serological one.

Adolescent↗
PubMedDate not supplied

[The modelling of hepatitis A in macaques].

Characteristics of experimental hepatitis A in Macaca fascicularis and M. mulatta produced with HAV, strain MP, isolated from M. mulatta in an outbreak of spontaneous hepatitis are presented. The HAV-MP strain induced the disease in all the animals used in the experiment. The infection was manifest, with all virological, serological, biochemical and morphological features typical of hepatitis A. In M. mulatta, the process was protracted, with virus persistence in feces for at least 4 months. Modeling of hepatitis A in Macaca monkeys using HAV-MP strain may be used for the study of the pathogenesis and trials of immune preparations.

Alanine Transaminase↗