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M D Brilliant

Publications and source records attributed to M D Brilliant.

At least 19 recordsLinked to original sources
PubMed1990

[Determining the accumulated dose of gamma radiation in the tooth enamel].

Following ideas of Japanese and Canadian scientists the authors tried to develop practical application of dental enamel for dosimetry of gamma-radiation accumulated by an individual. Human teeth were irradiated in vitro with gamma-rays of 60Co and with x-rays, and the amount of free radicals in ++non-caries enamel was measured on an ESR spectrometer. Linear regression ESR signals on dose of radiation within an interval of 0.1-20 Gy were plotted for gamma- and x-rays with regression coefficients 0.276 and 0.693, respectively. These regressions were used for estimation of accumulated doses of gamma-radiation in 85 residents of Byelorussia and 301 residents of the Tomsk region during investigation of teeth that were removed in normal dental practice.

Adult↗
PubMed1990

[Age-related differences in hematopoietic progenitor cells and the problems of carcinogenesis].

In the past years the authors advanced a hypothesis of the "age-associated layers" of parent hemopoietic cells. The hypothesis was based first of all on the differences in the patterns of leukemias and noncancerous diseases (of the hemopoietic tissues) in children and adults. The nature of the changing age-associated characteristics of parent cells remained obscure. Analysis of leukemias and epithelial tumors of radiation nature, formed in the victims to nuclear bomb explosion in Japan in 1945, analysis of leukemias occurring in persons with genetic diseases characterized by the known chromosomal aberrations (Down's syndrome, Louis-Bar syndrome, etc.), studies into the inherited forms of leukemias (chronic lympholeukemia, subleukemic myelosis, etc.--all these conditions are marked by the unstable genetic apparatus and high mutability) allowed the authors to make a conclusion about a kit of active differentiation genes which are replaced in health with age. Cancerous transformation may take place just at the level of those genes in parent cells with an unstable genome, since there appear specific mutation (in contrast to nonspecific ones characterizing the unstable genome) and a cancerous clone.

Adult↗
PubMed1990

[Problem of radiation-induced leukemia].

A case of radiation-induced leukemia has been described in a woman living in the area exposed to radioactive contamination as a result of the disaster at the Chernobyl NPS. Radiation-induced leukemia was diagnosed basing on the cytogenetic changes in the bone marrow and peripheral blood lymphocytes. Cytogenetic changes in the peripheral blood lymphocytes have been recorded in 60 subjects who were evacuated from areas contaminated with isotopes as a result of the disaster.

Accidents↗