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Biomedical subjects

M D Connole

Publications and source records attributed to M D Connole.

At least 19 recordsLinked to original sources
PubMed1992

Rhinocerebral and nasal zygomycosis in sheep caused by Conidiobolus incongruus.

The clinical findings, pathology and mycology of a cluster of 5 ovine cases of rhinocerebral and nasal zygomycosis caused by Conidiobolus incongruus are described. All cases were in Border Leicester or Merino x Border Leicester ewes from a flock pastured in a low-lying paddock adjoining a small tidal river in subtropical Queensland (latitude 28 degrees S). These cases of zygomycosis are believed to be the first infections due to C incongruus recorded in animals other than humans. The disease was subacute in 4 animals with a course of up to several weeks. In these, the primary site of infection was the posterior nasal cavity. The lesions extended to the dorsum of the face between the eyes, to the orbital cavity and to the anterior brain and meninges in the cranial cavity. In one animal, where the anterior nasal cavity was affected and iodine treatment used, the course was longer. The fungal granulomas had numerous foreign body giant cells, neutrophils and eosinophils. Fungal hyphae were thin walled, 6 to 8 microns in diameter, with occasional septa and irregular branching. They were cuffed with a wide zone of necrotic cell coagulum, or with homogeneous eosinophilic Splendore-Hoeppli granules.

Animals↗
PubMed1990

Review of animal mycoses in Australia.

This review covers the available literature on the mycoses of animals in Australia since the last review published in 1967. Of the cutaneous infections, dermatophytoses have been recorded in a wide range of animals: cattle, horses, goats, pigs, sheep, cats, dogs, mice, guinea-pigs, rabbits, a lion, kangaroos, a camel, koalas and wallabies. These infections were caused by several species and varieties of the genera, Microsporum and Trichophyton. Eight agents of ringworms have been recorded in the horse. Two subcutaneous mycoses, phaeohyphomycosis and sporotrichosis have been reported. Phaeohyphomycosis is becoming more common but sporotrichosis is rare having been recorded only once in a cat. The following systemic mycoses have been recorded: adiaspiromycosis, aspergillosis, candidiasis, cryptococcosis, dactylariosis, fusariomycosis, histoplasmosis, miscellaneous mycoses, mycotic abortion and related conditions, zygomycosis, pythiosis, protothecosis and green algal infections. Cryptococcosis has affected 11 different animal species. Mycotic abortion is a serious disease in Victoria. Pythiosis of horses has been extensively studied in northern Australia.

Animals↗
PubMed1984

Subcutaneous phaeohyphomycosis caused by Moniliella suaveolens in two cats.

Moniliella suaveolens was isolated in pure culture from histologically typical phaeohyphomycotic granulomas containing dematiaceous fungi in two cats. One cat had several slow-growing black lesions up to 2 cm in diameter in the abdominal subcutis. These lesions recurred after surgical excision was attempted. The second cat had a single black subcutaneous 0.5 X 1.5-cm lesion near one dewclaw. This lesion was successfully removed surgically without recurrence. M. suaveolens has not been isolated previously from lesions in animals including man.

Animals↗
PubMed1981

Acute aflatoxicosis in calves fed peanut hay.

Acute aflatoxicosis was believed to be the cause of death of 12 to 90 drought-stricken Hereford calves fed peanut hay on the southern Darling Downs in Queensland. Jaundice, photosensitisation, diarrhoea, anorexia and depression were seen before death. Serum levels of enzymes of hepatic origin and bilirubin were elevated. After death haemorrhage, hepatocyte damage, bile ductule proliferation were found. Total aflatoxin levels up to 2230 microgram/kg were detected in the peanut hay with most toxin concentrated in nut-in-shell.

Aflatoxins↗
PubMed1981

Mycotoxins in animal feeds and toxic fungi in Queensland 1971-80.

During the years 1971 to 1980, 355 samples of animal feeds submitted to this laboratory in connection with suspected mycotoxicoses were analysed for aflatoxins. Most major Queensland agricultural crops were represented. Aflatoxins were detected in 67 samples, 45 of which were peanut meals and by-products (55% of all peanut materials analysed). Of 200 Aspergillus flavus isolates cultured on maize meal, aflatoxins were produced by 49%. Ochratoxin A was detected in one sample of another 25 feeds analysed for the compound. Ochratoxin A was produced by 28% of 47 A. ochraceus isolates, and two Fusarium equiseti isolates produced zearalenone. The present situation with regard to mycotoxins and mycotoxicosis in Queensland is briefly reviewed.

Aflatoxins↗
PubMed1977

Eumycotic mycetoma due to Drechslera rostrata infection in a cow.

A case of eumycotic mycetoma with lesions in the skin, nasal cavity and lymph nodes of a cow is reported. The case history, clinical course, macroscopic and microscopic appearance of lesions, and fungal isolation are described. Drechslera rostrata was isolated from pathological tissue and Koch's postulates were satisfied on mouse inoculation. This is the first infection of its type recorded in Australia and features contrasting with cases reported in other countries are discussed.

Animals↗
PubMed1977

Mycotic nasal granuloma in cattle.

Seven cases of eosinophilic granulomas containing fungal chlamydospores and short septate hyphae in the submucosa of the anterior nasal cavity were described from Queensland beef cattle during 1966-75. Drechslera rostrata was isolated from 2 cases and unidentified dematiaceous fungi from 2 others.

Animals↗
PubMed1975

Canine aflatoxicosis.

Poisoning with aflatoxin derived from mouldy bread was confirmed as the cause of death of one dog and was suspected as the cause of death of two other dogs on the same ration. A jaundiced carcass, firm bile-stained liver and haemorrhage into the gastro-intestinal tract were seen at autopsy. Swelling and foamy vacuolation of hepatocytes due to fatty infiltration, marked perioportal proliferation of bile ductules and some periacinar necrosis were the microscopic changes seen in the liver. Aspergillus flavus was isolated from the mouldy bread and also from a sample of vomitus. Aflatoxin B1, 6.7 ppm, was detected in the mouldy bread and extremely high levels of 100 ppm of aflatoxin B1 and 40 ppm of aflatoxin G1 were present in a sample of vomitus.

Aflatoxins↗