PubMed Health⌕ Search

Biomedical subjects

M D Foadi

Publications and source records attributed to M D Foadi.

10 recordsLinked to original sources
PubMed1990

Molecular analysis of a CML patient with a long duration of chronic phase before and after lymphoid blast crisis.

A patient who was diagnosed with chronic myeloid leukemia remained in chronic phase for 14 years before progressing into a lymphoid blast crisis in 1983. The acute phase was successfully treated, and the patient has remained in an indolent chronic phase to date. Cytogenetic and molecular analysis during this second chronic phase confirm the presence of the Philadelphia chromosome and its transcribed BCR-ABL mRNA. The breakpoint within M-bcr occurred in the 3' portion of the region and expressed a hybrid joining the b3 exon of BCR to the a2 exon of ABL.

Blast Crisis↗
PubMed1986

Fatal familial haemolytic anaemia.

A 19-year-old man, mentally handicapped but physically well, died within 2 days of onset of an acute episode of gastrointestinal upset and "haematuria." Autopsy and microscopy suggested a haemolytic episode and family studies showed haemolytic anemia due to glucose-6-phosphate dehydrogenase deficiency, which was almost certainly present in the deceased.

Adult↗
PubMed1978

Erythrophagocytosis by acute lymphoblastic leukaemic cells.

Phagocytosis of erthyrocytes and platelets by bone marrow blast cells has been noted in 4 patients in the late relapse of acute lymphoblastic leukaemia (ALL). The underlying mechanism is unclear but prolonged course of the disease seems to be a major factor in the emergence of cells with phagocytic properties.

Adolescent↗
PubMed1977

Portal hypertension in a patient with chronic myeloid leukaemia.

A patient with chronic myeloid leukaemia treated with busulphan for 4-5 years, developed signs of busulphan toxicity and portal hypertension with ascites, oesophageal varices and jaundice. At post-mortem there was minimal leukaemic infiltration but there were alterations in the liver architecture sufficient to explain the portal hypertension. The pathogenesis of the liver changes and their possible relationship to splenomegaly and busulphan toxicity are considered.

Busulfan↗
PubMed1977

Tetraploid cell line in a girl with acute leukaemia.

In a girl with atypical acute leukaemia the malignant cell line in peripheral blood and bone marrow during these relapses was found to be tetraploid. The abnormal cells were more proliferative than those usually present in acute leukaemia. The tetraploid DNA content of the blast cells distinguished them from other cells in blood and bone marrow from this patient and from the blast cells found in other instances of acute lymphoblastic leukaemia.

Bone Marrow↗
PubMed1975

Bone marrow appearances in reticulum cell sarcoma.

18 patients with malignant lymphoma "histiocytic type" were investigated for the bone marrow involvement. Bone marrow aspirates and needle biopsies were used. Smears and sections of the aspirates were examined. The findings in the sections of both aspirates and biopsies were complementary and far more valuable than the bone marrow smears alone. It is concluded that bone marrow examination is helpful in determining the spread of the disease and should be repeated during the course of lymphoma.

Adult↗