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Biomedical subjects

M D Garcia

Publications and source records attributed to M D Garcia.

At least 37 records · Page 2Linked to original sources
PubMed1986

Almost total absence of the left ventricular myocardium with dextro-transposition of the great arteries.

The term parchment heart is used to describe partial to nearly complete loss of ventricular myocardium. We report the first case of transposition of the great arteries with almost total absence of left ventricular myocardium. The latter was not recognized and the child underwent Mustard's operation at four months of age. He died on the operating table. At necropsy, the left ventricular wall was 1 mm in thickness; microscopic examination revealed few myocardial fibers within edematous connective tissue.

Heart Defects, Congenital↗
PubMed1985

[Sutton's periadenitis mucosa necrotica recurrens. An optical-ultrastructural case study].

An optic-ultrastructural study is realized, emphazising the presence of: a) Intermediate lymphocytes, that we interpret as T-activated; b) Activated endothelial cells (prominent, rich in Weibel-Palade's bodies, well developed nuclei- and cytoskeletons); c) Classic and native myofibroblasts, partially responsible for the cicatricial contraction. We postulate that the changes in the connective-vascular tissue of the chorion represent an anarchic and reactive fibroangioblastic hyperplasia and favors the typical recurrences of this process.

Adolescent↗
PubMed1984

[Aberrant left pulmonary artery and acute respiratory insufficiency in infants].

The aberrant left pulmonary artery is a rare disease, producing severe respiratory failure in the neonatal period and early infancy. The diagnosis is easy and mainly done by X-ray. Although the main diagnostic procedure continues to be an elective angiography in the main pulmonary artery, the diagnosis may be confirmed by a contrast computerised axial tomography. It is necessary to use the classic tomography to rule out any associated tracheobronchial anomalies, and thus avoid other dangerous diagnostic procedures such as bronchoscopy and bronchography. Having reviewed previous publications, two cases are presented, one, being exceptional with left lung emphysema.

Acute Disease↗
PubMed1977

Plasma and pituitary thyrotrophin (TSH) in severe and prolonged hypothyroidism, as studied in the rat.

Thyroidectomized rats, kept on a low iodine diet, were killed at 60, 80 and 270 days after thyroidectomy and plasma and pituitary TSH levels measured. Pituitary TSH content was lowere in the thyroidectomized rats than in the controls at 60 and 80 days, starting to increase between 60 and 80 days, and reaching higher values than those of the controls by 270 days. Plasma TSH was higher in the thyroidectomized rats than in the controls at all the times studied, but declined markedly between 60 days (17.53 +/-1.98 mug/ml) and 270 days (3.63 +/-0.49 mug/ml. This decrease in plasma TSH levels was accompanied by a decrease in plasma PBI: from 0.69+/-0.08 mug/dl at 60 days to 0.06+/-0.01 mug/dl at 270 days. The daily injection of 1.75 mug T4/100 g body weight for 12 days in either thyroidectomized rats or normal intact rats resulted in a decline of plasma TSH levels in both groups. Pituitary TSH content increased in the thyroidectomized rats and decreased in the controls after T4 treatment. Present results agree with previous observations indicating that severe and chronic thyroid hormone deficiency is not accompanied by a progressive increase in circulating TSH levels, though an elevation is always fou nd even in mild or subclinical forms or primary hypothyroidism. They show that in the rat this connot be accounted for by an impairment of TSH synthesis, as previosly suggested: an impairment of TSH secretion appears more probable.

Animals↗
PubMed1976

Decreased pituitary growth hormone content in rats treated neonatally with high doses of L-thyroxine.

Growth hormone and thyrotrophic hormone content have been measured by specific radioimmunoassays in anterior pituitaries of 22 day old rats. These animals were injected with saline or very high doses of L-thyroxine during the neonatal period in order to induce the "neo-T4" syndrome. Growth of such animals is known to be affected. It was found that not only TSH but also GH content of the T4-treated animals was significantly lower than that of the saline-injected controls.

Animals↗
PubMed1975

The changes of thyroglobulin in the lysosomal particles of thyroid during the postnatal period in rats.

The distribution of radioactivity and protein-SH groups was studied in neonatal rats injected with 125-I- in the 15,000 g pellets of thyroid glands to obtain information about the colloid which undergoes phagocytosis by lysosomes. The 15,000 g pellet was solubilized in Triton X--100. The soluble portion was enhanced on the 16th day of age, whereas the portion of the insoluble fraction remained almost unchanged. The content of protein-SH groups in the insoluble fraction decreased with age and was increased in the soluble fraction. The concentration of immunoreactive thyroid stimulating hormone (TSH) in the pituitary and in the blood of rats during ontogenesis was higher on the first day after delivery, then decreased within the first seven days and again markedly increased during the third postnatal week. It was concluded that higher amounts of Triton soluble thyroglobulin occurring during the postnatal period in rats reflects the availability of more substrate, i.e. thyroglobulin for pinocytosis and partially depends upon the TSH level. These findings also support the suggestion on maturation of the pituitary-thyroid system during the postnatal period in rats.

Animals↗