Some unorthodox views and a selection hypothesis on the origin of the AIDS viruses.
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Biomedical subjects
Publications and source records attributed to M D Grmek.
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Several medieval cities on the eastern coast of the Adriatic Sea renewed the Byzantine tradition of hiring a public physician, thus offering their citizens the service of qualified doctors. The case of Ragusa is typical. The archives of this city-state have been preserved since the XIIIth century; the names, origins and professional titles of public physicians are well known. The conditions of their employment reveal not only their duties and the salary but also many aspects of communal hygiene and medical ethics.
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Paleopathological data support the hypothesis that malaria recrudescences in Greece occurred at the Mesolithic, at the top of the classic period and at the beginning of the Turkish conquest. Malaria due to Plasmodium falciparum did not appear until the 5th century B.C.
To avoid misinterpretations one should substitute the ambiguous notion of 'new disease' with 'emerging disease'. A disease can be classified emergent in at least five different historical situations; 1) it existed before it could be first identified but was overlooked from a medical point of view because it could not be conceptualized as a nosological entity; 2) it existed but was not noticed until a quantitative and/or qualitative change in its manifestations; 3) it did not exist in a particular region of the world before its introduction from other regions; 4) it never existed in a human population but only in an animal population; 5) it is completely new--the triggering germ and/or necessary environmental conditions did not exist prior to the first clinical manifestations. A series of historical examples illustrate this classification.
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