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Biomedical subjects

M D Kaye

Publications and source records attributed to M D Kaye.

At least 55 records · Page 3Linked to original sources
PubMed1976

Manometric studies of the human pylorus.

The human gastroduodenal junction was investigated by means of simultaneous measurements of pressure and potential difference between skin and mucosa. An accurate and circumferentially sensitive miniature transducer assembly failed to reveal a zone of elevated pressure at the gastroduodenal junction of 8 fasting, healthy, young subjects. Additional studies were carried out with a six-lumen perfused catheter system, in which three of the pressure-transmitting catheters had openings arranged circumferentially at the same axial level. Measurements of pressure and potential difference were obtained basally during intraduodenal infusion of hydrochloric acid and after intraduodenal instillation of olive oil. In only 1 of 10 subjects was a tonic elevation in pressure recorded simultaneously by all three leads at the gastroduodenal junction. The normal human pylorus, therefore, is not reliably demonstrable as a high pressure zone.

Adult↗
PubMed1972

Normal deglutitive responses of the human lower oesophageal sphincter.

The responses to deglutition of the lower oesophageal high pressure zone were studied in 13 healthy subjects. The recording assembly included three perfused pressure recording catheters, whose recording orifices were at the same axial level, and a more distally situated pH electrode. Relaxation and contraction progressed in a sequential fashion along the length of the high pressure zone. At the time of maximum relaxation, a small pressure gradient, which was greatest at a point approximately 1 cm distal to the pressure inversion point, was maintained between stomach and oesophagus. The frequency of post-deglutitive contractions in the high pressure zone, which were observed to occur distal to the pressure inversion point in all subjects, steadily increased as the recording assembly was withdrawn proximally. The amplitude of such contractions was greater in the high pressure zone than in the distal oesophagus. There was a significant correlation between maximum resting pressure and amplitude of contractions within the high pressure zone. The proper assessment of the function of the high pressure zone should include consideration of the spatiotemporal relationships of pressure events within the lower oesophagus and the high pressure zone, in addition to measurements of their absolute dimensions. The pH electrode measurements, performed after the intragastric instillation of at least 150 ml of 0.1 N HCl, showed transient falls in the pH of the distal high pressure zone after deglutition in all subjects. These pH responses decreased in frequency as the pH electrode was withdrawn proximally, and did not occur in the non-sphincteric oesophagus. It would appear therefore that although gastroesophageal competence is retained during swallowing, the mucosal lining of the greater part of the high pressure zone is briefly exposed to gastric contents for a few seconds after deglutition.

Adult↗