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Biomedical subjects

M D Levin

Publications and source records attributed to M D Levin.

At least 37 records · Page 2Linked to original sources
PubMed1989

[Diagnosis and surgical treatment of gastroesophageal reflux in children].

Results of observations examination and treatment of 115 children with gastroesophageal reflux aged from 3 days to 14 years are described. Great importance of special methods of examination was shown. Results of using the roentgenological method, fibroesophagogastroscopy with biopsy of the esophagus, manometry and electromyography of the esophagus are presented. Specific features and results of the surgical treatment of the disease are described.

Adolescent↗
PubMed1984

Translocation 1;19--a new cytogenetic abnormality in acute lymphocytic leukemia.

A study of the chromosomes of 125 consecutive patients with acute lymphocytic leukemia (ALL) showed the same translocation between chromosomes #1 and #19 in 5 patients. In 4 of the 5, the t(1;19)(q21;q13) was present at diagnosis. The fifth patient, who had Philadelphia chromosome positive (Ph1+) ALL, developed t(1;19) in first relapse. Trisomy 1q was involved in 2 of the 5 patients; 3 patients had additional abnormalities. All patients had low white cell counts at presentation (less than 35 X 10(9)/L), and the 4 patients tested had common ALL antigen (CALLA) positive leukemic blast cells. All achieved complete remission, including the Ph1+ ALL patient in first relapse, and survival times ranged from 4 to 21+ mo from the time the t(1;19) first appeared. Our data suggest that t(1;19) is a previously unrecognized nonrandom structural abnormality in ALL that is also found in other lymphoid malignancies. Unlike the other specific translocations, it is not associated with a poor prognosis.

Adolescent↗
PubMed1984

Clinicopathological characteristics of acute lymphoblastic leukemia with the 4;11 chromosome translocation.

Analysis of the bone marrow karyotype in 109 consecutive untreated patients with acute lymphoblastic leukemia (ALL) by the G-banding technique revealed the presence of a translocation between specific sites on the long arms of chromosomes 4 and 11, [t(4;11) (q21;q23)] in 3 adults and 2 children. Splenomegaly was present in all patients, marked leukocytosis in 4, and retinal hemorrhages in the absence of significant mucocutaneous bleeding in 3. Complete remission defined by conventional morphological criteria was achieved with combination chemotherapy in all instances, but the duration of remission was brief in 3. Three patients were studied in relapse, and clonal evolution was found to have occurred in 2. Analysis of our data in conjunction with other published reports suggests this specific karyotypic abnormality characterizes a small subgroup of ALL in which there is a strong association with recognized clinical and laboratory indices of poor prognosis, in particular its frequent occurrence in children under the age of 2.5 yr. There is a propensity to undergo clonal evolution, and the possibility exists that such a development is associated with poor prognosis.

Adolescent↗