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Biomedical subjects

M D Litvinchuk

Publications and source records attributed to M D Litvinchuk.

8 recordsLinked to original sources
PubMed1990

[Effect of electrophoresis of the head region on benzylpenicillin penetration across the blood-brain barrier].

A procedure for administration of sodium benzylpenicillin (SB) to the brain was developed and tested on 22 rabbits. SB was administered drop-like intravenously in a dose of 200,000 units/kg body weight in combination with electrophoresis of the head area. It was shown spectrophotometrically that a single administration of SB increased its concentration in the liquor and brain tissues by 366.7 and 500 per cent respectively as compared to the control values. Practically no shifts in the EEG and ECG were observed which was indicative of safety of SB administration by that route. The procedure for intraorgan administration of SB in combination with electrophoresis may be recommended for clinical use.

Animals↗
PubMed1976

[A rapid method standardizing cholagogue substances on mice].

The authors described a rapid method of selection and quantitative assessment of the specific activity of substances (insulin, chologon and mebethizol: 2-mercaptobenzthiazol with a cholagogue action of mice. The gall bladder obtained from the animals was weighed with and wihtout the bile; it was thus possible to determine the amount of bile accumulated in the gall bladder under the action of the agents under study during a definite period of time. The method described may be used for pharmacological screening.

Animals↗
PubMedDate not supplied

[Fistula-free method of evaluating cholagogue agents on rats].

A new fistula-free method for standardizing and studying the choleretic activity of drugs on white rats is proposed. In rats under ether-urethane anestheia, a "biological test tube" of varied length where the bile is excreted, is created by ligation of the duodenum above and below the site of communication with the bile duct. In order to recover the patency of the digestive tract, the stomach or the proximal segment of the intestine is connected to its distal strip by a polyethylene tube. Supply of pancreatic juice to the "biological test tube" is eliminated by ligation of the pancreatic gland duct. The amount of bile (mg) excreted during a certain period of time, is established from the weight difference between the filled and bile-free dissected isolated segment of the duodenum. The choleretic activity of the drug is assessed in a similar way. The trial of the method performed on 50 rats, with the use of choleretic test-preparations (insulin and mebethisol) confirmed its sensitivty. The method proposed can be recommended for preliminary screening and dynamic study of the choleretic activity of drugs.

Animals↗
PubMedDate not supplied

[Spasmolytic properties of pyrrolizidine alkaloids].

Acute toxicity, spasmolytic and hypotensive properties of the alkaloids senecionine, d-otocenine and floridanin isolated from Senecio Erraticum L. were studied. D-otocenine and floridanin elicited low toxicity, while senecionine and d-otosenine showed spasmolytic and floridanin predominantly hypotensive properties.

Animals↗