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Biomedical subjects

M D Reuber

Publications and source records attributed to M D Reuber.

At least 37 records · Page 2Linked to original sources
PubMed1977

Carcinomas of the liver and forestomach in mice ingesting chlorobenzilate.

The maximal tolerated dose of chlorobenzilate was given by continuous oral administration, starting at the age of 7 days, to both sexes of two hybrid strains of mice-(C57BL/6 X C3HAnf)F1 and (C57BL/6 X AKR)F1. There was an increased incidence of tumors in one or more organs in male mice of both strains and female mice of the (C57BL/6 X C3HAnf)F1 strain. Male mice of both strains developed significantly elevated incidences of carcinomas of the liver. Female (C57BL/6 X C3HAnf)F1 strain mice had a significantly increased incidence of hyperplasia and carcinomas of the forestomach.

Animals↗
PubMed1977

Necropsy of animals for scientific research.

Techniques for the necropsying of animals and the trimming of tissues for histologic sections have been described for scientific research. It has been helpful to refer to the description, records, fixatives, and to other special procedures. The comment explains the reasons for using some of the procedures.

Animals↗
PubMed1976

Increased incidence of carcinoma of the breast in Buffalo strain rats with one kidney ingesting N-4-(4'-fluorobiphenyl)acetamide.

The role of the kidney in carcinogenesis of the breast was studied in inbred Buffalo strain female rats ingesting 0.04% N-4-(4'-fluorobiphenyl)acetamide. The experimental groups consisted of intact female rats 5 weeks of age with both kidneys intact and female rats with a uninephrectomy. The incidence of carcinomas of the breast and the number of rats with multiple carcinomas, poorly and undifferentiated carcinomas was greater in rats with a uninephrectomy. N-4-(4'-fluorobiphenyl)acetamide and its active metabolites apparently were not excreted as rapidly in the rats with one kidney as in the animals with both kidneys intact. The metabolites were then returned to the breast and/or other organs.

Aminobiphenyl Compounds↗
PubMed1976

Leiomyomas and leiomyosarcomas of the kidney in 4-day-old BUF rats given methylazoxymethanol acetate intraperitoneally.

The effect of age and sex on the development of renal tumors was studied in inbred BUF male and female rats 4 days, 5, 8, 12, 24, or 52 weeks old. Methylazoxymethanol (MAM) acetate was injected ip (20 mg/kg body wt) once weekly for 9 weeks. Animals 52 weeks old died from hepatic and/or renal necrosis; however, animals of other ages survived 24-42 weeks. Female rats 4 days old were susceptible to the development of leiomyomas and leiomyosarcomas of the kidney, whereas 4-day-old male rats had a few leiomyomas. Adenomas and carcinomas of the kidney and nephroblastomas were not observed. It was concluded that the aglycone of cycasin, MAM, is important in the induction of leiomyosarcomas of the kidneys in 4-day-old rats.

Age Factors↗
PubMed1976

Various degrees of susceptibility of different stocks of rats to N-2-fluorenyldiacetamide hepatic carcinogenesis.

Outbred Osborne Mendel, Japanese, Wistar, NIH Black, and Sorague-Dawley male rats 12 weeks of age ingested 0.025% N-2-fluorenyldiacetamide in a semisynthetic diet Sprague-Daeley and NIH Black male rats were most susceptible to the development of carcinomas and cirrhosis of the liver and also had the highest incidence of metastases. More and larger carcinomas per liver and more poorly differentiated and undifferentiated carcinomas were found, as well as more advanced cirrhosis, Japanese and Wistar male rats were susceptible, but less so, to hepatic carcinogenesis and cirrhosis. These rats had fewer and smaller hepatic carcinomas per liver, and the neoplasms were well differentiated. By contrast, Osborne Mendel male rats were least susceptible to hepatic carcinogenesis and cirrhosis.

2-Acetylaminofluorene↗
PubMed1976

Adenocarcinoma of the kidney. I. Ultrastructure of renal adenocarcinomas induced in rats by N-(4'-fluoro-4-biphenylyl)acetamide.

The ultrastructure of tumors induced in kidneys of F344 rats by the carcinogen N-(4'-fluoro-4-biphenylyl)acetamide appeared similar in many aspects to that described in humans and other animal models. The neoplastic cells exhibited microvilli resembling brush border and other adaptations of the cell membrane. Tumor lobules were surrounded by basement membrane-like material, which also extended into the tumor mass between individual cells. The ultrastructure appeared to reflect a proximal tubular origin of these lesions.

Adenocarcinoma↗
PubMed1976

Effect of age and sex on lesions of the esophagus in Buffalo strain rats ingesting diethylnitrosamine.

Inbred Buffalo male and female rats, 4, 12, 24, and 52 weeks of age, ingested 0.0114% diethylnitrosamine in a semisynthetic diet. Both age and sex were important in the development of preneoplastic and neoplastic lesions of the esophagus. The 4-week-old male rats had notably more carcinomas of the esophagus than female rats of the same age; whereas, 12-week-old male rats had only slightly more carcinomas than the females. The incidence of esophageal lesions was about the same in 24-week-old males and females. Rats 52 weeks of age were not susceptible to esophageal carcinogenesis.

Age Factors↗
PubMed1976

Carcinomas of the colon in Buffalo strain rats given intraperitoneal injections of methylazoxymethanol acetate.

Buffalo strain male and female rats were given methylazoxymethanol acetate (20% solution) intraperitoneally 20 mg/kg body weight weekly for 9 weeks, and killed 27 weeks later. Carcinomas of the large intestine, predominantly in the descending colon, developed in some of the rats. The incidence was higher in male than in female rats. Polypoid carcinomas were observed more often in male rats and sessile carcinomas with metastases in the female rats. Carcinomas were not observed in organs other than the large intestine.

Adenocarcinoma↗
PubMed1976

Role of age and sex in chronic thyroiditis in rats fed 3'-methyl-4-dimethylaminoazobenzene.

Inbred male and female Buffalo strain rats were started at 4, 8, 12, 24, or 52 weeks of age on 0.06% 3'-methyl-4-dimethylaminoazobenzene in a low-protein, choline-deficient diet. Eight-week-old males and females were the most susceptible to the development of chronic thyroiditis, but females were more susceptible than the males. Female rats of other ages developed a slightly higher incidence of thyroiditis than the male rats, the difference being most noticeable for rats 12 weeks old.

Age Factors↗
PubMed1976

Increased susceptibility to carcinoma of the liver in rats with one kidney ingesting N-4-(4'-fluorobiphenyl) acetamide.

The role of the kidneys in hepatic carcinogenesis was studied in inbred Buffalo strain male rats ingesting 0.04% N-4-(4'-flourobiphenyl) acetamide in the diet. Experimental groups were made up of male rats with both kidneys intact and male rats with the left kidney removed. The incidence of carcinomas of the liver and the number of rats with large carcinomas, multiple carcinomas, poorly differentiated and undifferentiated carcinomas, and metastases were greater in rats with a uninephrectomy. Apparently the animals with one kidney removed were unable to secrete the metabolites of N-4-(4'-fluorobiphenyl) acetamide as readily as the rats with both kidneys.

Aminobiphenyl Compounds↗
PubMed1975

Hyperplastic and neoplastic lesions of the kidney in Buffalo rats of varying ages ingesting N-4-(4'-flurobiphenyl)acetamide.

Inbred Buffalo male and female rats 4, 12, 24, and 52 weeks of age ingested 0.04% N-4(4'-fluorobiphenyl)acetamide in a semisynthetic diet for 36 weeks. Animals were killed 12 weeks later. Male rats 24 weeks old were more susceptible to the development of carcinomas of the kidney than were female rats of the same age or younger or older animals of both sexes. Rats with renal cell carcinomas either did not have hepatic carcinomas or had small ones.

Acetamides↗