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Biomedical subjects

M D Reuber

Publications and source records attributed to M D Reuber.

At least 109 records · Page 6Linked to original sources
PubMed1976

Leiomyomas and leiomyosarcomas of the kidney in 4-day-old BUF rats given methylazoxymethanol acetate intraperitoneally.

The effect of age and sex on the development of renal tumors was studied in inbred BUF male and female rats 4 days, 5, 8, 12, 24, or 52 weeks old. Methylazoxymethanol (MAM) acetate was injected ip (20 mg/kg body wt) once weekly for 9 weeks. Animals 52 weeks old died from hepatic and/or renal necrosis; however, animals of other ages survived 24-42 weeks. Female rats 4 days old were susceptible to the development of leiomyomas and leiomyosarcomas of the kidney, whereas 4-day-old male rats had a few leiomyomas. Adenomas and carcinomas of the kidney and nephroblastomas were not observed. It was concluded that the aglycone of cycasin, MAM, is important in the induction of leiomyosarcomas of the kidneys in 4-day-old rats.

Age Factors↗
PubMed1976

Various degrees of susceptibility of different stocks of rats to N-2-fluorenyldiacetamide hepatic carcinogenesis.

Outbred Osborne Mendel, Japanese, Wistar, NIH Black, and Sorague-Dawley male rats 12 weeks of age ingested 0.025% N-2-fluorenyldiacetamide in a semisynthetic diet Sprague-Daeley and NIH Black male rats were most susceptible to the development of carcinomas and cirrhosis of the liver and also had the highest incidence of metastases. More and larger carcinomas per liver and more poorly differentiated and undifferentiated carcinomas were found, as well as more advanced cirrhosis, Japanese and Wistar male rats were susceptible, but less so, to hepatic carcinogenesis and cirrhosis. These rats had fewer and smaller hepatic carcinomas per liver, and the neoplasms were well differentiated. By contrast, Osborne Mendel male rats were least susceptible to hepatic carcinogenesis and cirrhosis.

2-Acetylaminofluorene↗
PubMed1976

Adenocarcinoma of the kidney. I. Ultrastructure of renal adenocarcinomas induced in rats by N-(4'-fluoro-4-biphenylyl)acetamide.

The ultrastructure of tumors induced in kidneys of F344 rats by the carcinogen N-(4'-fluoro-4-biphenylyl)acetamide appeared similar in many aspects to that described in humans and other animal models. The neoplastic cells exhibited microvilli resembling brush border and other adaptations of the cell membrane. Tumor lobules were surrounded by basement membrane-like material, which also extended into the tumor mass between individual cells. The ultrastructure appeared to reflect a proximal tubular origin of these lesions.

Adenocarcinoma↗
PubMed1976

Effect of age and sex on lesions of the esophagus in Buffalo strain rats ingesting diethylnitrosamine.

Inbred Buffalo male and female rats, 4, 12, 24, and 52 weeks of age, ingested 0.0114% diethylnitrosamine in a semisynthetic diet. Both age and sex were important in the development of preneoplastic and neoplastic lesions of the esophagus. The 4-week-old male rats had notably more carcinomas of the esophagus than female rats of the same age; whereas, 12-week-old male rats had only slightly more carcinomas than the females. The incidence of esophageal lesions was about the same in 24-week-old males and females. Rats 52 weeks of age were not susceptible to esophageal carcinogenesis.

Age Factors↗
PubMed1976

Carcinomas of the colon in Buffalo strain rats given intraperitoneal injections of methylazoxymethanol acetate.

Buffalo strain male and female rats were given methylazoxymethanol acetate (20% solution) intraperitoneally 20 mg/kg body weight weekly for 9 weeks, and killed 27 weeks later. Carcinomas of the large intestine, predominantly in the descending colon, developed in some of the rats. The incidence was higher in male than in female rats. Polypoid carcinomas were observed more often in male rats and sessile carcinomas with metastases in the female rats. Carcinomas were not observed in organs other than the large intestine.

Adenocarcinoma↗
PubMed1976

Role of age and sex in chronic thyroiditis in rats fed 3'-methyl-4-dimethylaminoazobenzene.

Inbred male and female Buffalo strain rats were started at 4, 8, 12, 24, or 52 weeks of age on 0.06% 3'-methyl-4-dimethylaminoazobenzene in a low-protein, choline-deficient diet. Eight-week-old males and females were the most susceptible to the development of chronic thyroiditis, but females were more susceptible than the males. Female rats of other ages developed a slightly higher incidence of thyroiditis than the male rats, the difference being most noticeable for rats 12 weeks old.

Age Factors↗
PubMed1976

Increased susceptibility to carcinoma of the liver in rats with one kidney ingesting N-4-(4'-fluorobiphenyl) acetamide.

The role of the kidneys in hepatic carcinogenesis was studied in inbred Buffalo strain male rats ingesting 0.04% N-4-(4'-flourobiphenyl) acetamide in the diet. Experimental groups were made up of male rats with both kidneys intact and male rats with the left kidney removed. The incidence of carcinomas of the liver and the number of rats with large carcinomas, multiple carcinomas, poorly differentiated and undifferentiated carcinomas, and metastases were greater in rats with a uninephrectomy. Apparently the animals with one kidney removed were unable to secrete the metabolites of N-4-(4'-fluorobiphenyl) acetamide as readily as the rats with both kidneys.

Aminobiphenyl Compounds↗
PubMed1975

Hyperplastic and neoplastic lesions of the kidney in Buffalo rats of varying ages ingesting N-4-(4'-flurobiphenyl)acetamide.

Inbred Buffalo male and female rats 4, 12, 24, and 52 weeks of age ingested 0.04% N-4(4'-fluorobiphenyl)acetamide in a semisynthetic diet for 36 weeks. Animals were killed 12 weeks later. Male rats 24 weeks old were more susceptible to the development of carcinomas of the kidney than were female rats of the same age or younger or older animals of both sexes. Rats with renal cell carcinomas either did not have hepatic carcinomas or had small ones.

Acetamides↗
PubMed1975

Histopathology of breast lesions induced in BUF rats of varying ages by ingestion of N-4-(4'-fluorobiphenyl) acetamide.

Inbred BUF male and female rats 4, 12, 24, and 52 weeks old ingested 0.04 percent N-4-(4'fluorobiphenyl)-acetamide in a semisynthetic diet for 36 weeks. They were killed 12 weeks later. Susceptibility to mammary carcinogenesis was related to the age and sex of the animals. Younger female rats developed more mammary tumors. Approximately half of these mammary tumors were well-differentiated adenocarcinomas; the remainder were either poorly differentiated or anaplastic adenocarcinomas.

Acetamides↗
PubMed1975

Influence of sex and sex hormones on transplantable hepatocellular carcinoma in the rat.

Palpable subcutaneous transplants of hepatocellular carcinoma-35 appeared slightly earlier in male animals; however, the number of successful growths was no greater than that in female animals. Castration and administration of testosterone or diethylstilbestrol were performed after the transplants reached 1.0-1.5 cm in size. The carcinoma was less well differentiated histologically, had more bile pigment, grew rapidly, mestastasized sooner and killed the host quickly in castrated females given testosterone propionate. Bile was present in lung metastases. There was little difference in the growth rate in intact or castrated male or female animals. Exogenous diethylstilbestrol slowed the growth of the transplants and cause weight loss in castrated males. The weight loss was felt to be related to extensive necrosis of the carcinoma.

Animals↗
PubMed1975

Carcinoma and cirrhosis of the liver in A X C male rats with one kidney ingesting 0.025% N-2-fluorenyldiacetamide.

The role of the kidneys in hepatic carcinogenesis was studies in inbred A X C strain male rats ingesting 0.025% N-2-fluorenyldiacetamide. The experimental groups consisted of male rats with both kidney intact and male rats that had the left kidney removed. The incidence of hepatic carcinomas and the number of rats with large carcinomas, multiple carcinomas, poorly differentiated and undifferentiated carcinomas, and metastases was greater in rats with a left nephrectomy. The incidence of cirrhosis was the same in animals in both groups; however, cirrhosis was more severe in degree in the rats with the left kidney removed. Some animals in the latter group also developed carcinosarcomas of the salivary glands. The animals with one kidney apparently were not able to excrete the active metabolites of N-2-fluorenyldiacetamide as readily as the animals with both kidneys intact. The metabolites were then returned to the liver and salivary gland.

2-Acetylaminofluorene↗
PubMed1975

Influence of age and sex on carcinoma and cirrhosis of the liver in AXC strain rats ingesting 0.025% N-2-fluorenyldiacetamide.

Inbred A X C male and female rats, 4, 12, 24, and 52 weeks of age, ingested 0.025% N-2-fluorenyldiacetamide in a semisynthetic diet. Both age and sex were important in the development of hepatic lesions. The 4- and 12-week-old males developed a higher incidence of carcinomas and cirrhosis of the liver than did the females of the same ages or the males and females 24 and 52 weeks of age. Four-week-old male rats had more carcinomas per liver, larger carcinomas, more poorly differentiated (as compared with well differentiated), and some carcinomas were cholangiocellular as well as hepatocellular. There were a few hepatic lesions in the younger female rats; however, female rats of all ages were relatively resistant to hepatic carcinogenesis.

2-Acetylaminofluorene↗
PubMed1975

Histogenesis of hyperplasia and carcinomas of the liver arising around central veins in mice ingesting chlorinated hydrocarbons.

The development of hyperplastic and neoplastic lesions of parenchymal cells of the liver adjacent to central veins was observed in C3H mice ingesting the chlorinated hydrocarbons, dieldrin or aldrin, in the diet. Lesions could be followed from pericentral hyperplasia to areas of hyperplasia, nodules of hyperplasia, small hepatocellular carcinomas, and large well-developed carcinomas, occasionally with metastases. Sometimes pericentral hyperplasia was diffuse throughout most or all of one lobe of the liver. These hyperplastic cells collided to become one large nodule and also one large carcinoma. The carcinomas were well-differentiated or moderately well-differentiated and grew on transplantation to isologous hosts. Histologically, the hyperplastic cells adjacent to central veins were increased in size, frequently with double nuclei. Carcinoma cells varied in size and shape and were huge with large nuclei, prominent nucleoli, and eosinophilic cytoplasm. Similar hepatocellular carcinomas were seen previously with carbon tetrachloride, another organochlorine chemical.

Aldrin↗
PubMed1975

Hepatic vein thrombosis in Buffalo strain female rats ingesting dimethylnitrosamine.

Buffalo strain male and female rats 12 weeks of age ingested 0.0114% dimethylnitrosamine in a semisynthetic diet for 12 weeks. Hepatic vein thrombosis developed along with focal fibrosis of the liver in female rats. Male rats had focal hepatic fibrosis, but not thrombosis of hepatic veins. A high incidence of hepatic vein thrombosis has been observed previously in Buffalo strain rats given carbon tetrachloride and methylcholanthrene simultaneously.

Animals↗