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Biomedical subjects

M D Salman

Publications and source records attributed to M D Salman.

At least 19 recordsLinked to original sources
PubMed1992

Effects of chemotherapy and remission on carbohydrate metabolism in dogs with lymphoma.

After a 12-hour fast, blood samples were obtained from 27 dogs with previously untreated lymphoma before and 5, 15, 30, 45, and 60 minutes after an intravenous (IV) challenge with 500 mg/kg dextrose. This procedure was done for each dog before up to five treatments with the IV doxorubicin (30 mg/m2 every 3 weeks). All dogs achieved a complete remission. Samples were assayed for glucose, lactate, and insulin concentrations, and results were compared statistically with those from 16 normal control dogs of similar weight and age undergoing an identical dextrose challenge before and 3 weeks after receiving one dose of IV doxorubicin (30 mg/m2). Glucose, lactate, and insulin concentrations did not change significantly in response to glucose challenge in control dogs after doxorubicin chemotherapy. Lactate and insulin concentrations in untreated dogs with lymphoma were significantly higher than controls. This hyperlactatemia and hyperinsulinemia did not improve when dogs with lymphoma were put into remission with doxorubicin chemotherapy. The results indicate that carbohydrate metabolism is altered in dogs with lymphoma, and that these abnormalities do not improve when a complete remission is obtained with doxorubicin chemotherapy.

Animals↗
PubMed1992

Evaluation of an enzyme-linked immunosorbent assay for detection of antibodies to vesicular stomatitis virus in cattle in an enzootic region of Mexico.

An ELISA was compared with the plaque-reduction serum neutralization (PRSN) test, for detection of vesicular stomatitis virus (VSV) antibodies in cattle in a vesicular stomatitis enzootic region of Mexico. A total of 325 bovine serum samples were screened for VSV antibodies. The PRSN test was performed, using Vero cells. The ELISA contained gradient-purified VSV Indiana (Lab strain) and VSV New Jersey (Hazelhurst) as the antigens. Regression analysis and weighted kappa statistic were used to estimate measures of agreement between the 2 assays for detection of VSV antibodies. The ELISA method proved useful for serodiagnosis of vesicular stomatitis. The ELISA and PRSN test results were highly correlated for detection of VSV antibodies.

Animals↗
PubMed1992

Epidemiologic factors involved in perinatal lamb mortality on four range sheep operations.

Four shed-lambing operations in western Colorado were monitored during the 1984 spring lambing season to determine the causes and rates of perinatal lamb mortality. The number of lambing ewes per flock ranged from 513 to 1,712, and lambing percentages ranged from 131 to 180%. Overall perinatal lamb mortality ranged from 8.2 to 12.2%. Most lamb deaths occurred during parturition or within 24 hours after parturition. More than 85% of all lamb deaths were in lambs born to ewes having 2 or more lambs. The leading causes of lamb death were starvation, dystocia, stillbirth (unknown cause), and infectious diseases. A wheel model was used to categorize factors causing lamb deaths into 4 groups: physical, social, host, and biological, and to present data on perinatal lamb mortality in a simple visual model. In all flocks, social and biological factors resulted in most of the lamb deaths. On the basis of our findings, we suggest that interventions designed to improve ewe-lamb bonding and to reduce infectious agents and the incidence of prolonged parturition may reduce lamb mortality.

Animals↗
PubMed1991

Costs of veterinary services and vaccines/drugs used for prevention and treatment of diseases in 86 Colorado cow-calf operations participating in the National Animal Health Monitoring System (1986-1988).

Eighty-six cow-calf operations involved in the Colorado National Animal Health Monitoring System were monitored for a 12-month period, and data were collected on the incidence, prevention, and costs of disease. The costs of veterinary services and vaccines/drugs used in the treatment and prevention of disease conditions in these beef herds were determined and expressed on a per cow basis. Beef producers in this study spent an average of $2.04 ($0 to $29.88) per cow annually on veterinary services for treatment of disease conditions. The cost of veterinary services was a relatively small percentage (5.4%) of the total mean cost of disease incidence. The reproductive tract disease class was the most costly class in terms of veterinary services for disease treatment ($0.99/cow). Dystocia was the disease condition with the largest veterinary treatment cost. The total mean annual cost of drugs used in the treatment of disease conditions was $1.22/cow. The enteric, miscellaneous, and respiratory tract disease classes had similar mean drug costs for disease treatment and ranged from $0.31 to $0.39/cow. The total mean annual cost of veterinary services for administration of preventive measures in these herds was $1.85/cow ($0 to $12.03). Pregnancy examination, breeding soundness examination in bulls, brucellosis vaccination, pulmonary arterial pressure test, and campylobacteriosis vaccination accounted for over 90% of the money spent for preventive veterinary services. Approximately 60% of the total mean annual disease prevention cost was attributed to the purchase of vaccines/drugs ($6.59/cow).(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1991

Medical problems of adult horses, as ranked by equine practitioners.

This paper reports the results of a survey conducted among members of the American Association of Equine Practitioners, concerning medical problems of adult horses. A one-page questionnaire listing 36 medical problems grouped by body system was completed by 1,149 veterinarians. The top-ranked disease was colic, followed by viral respiratory tract disease, endometritis, dermatitis, and parasitism. When responses were evaluated by type of practice, location of practice, and number of veterinarians in the practice, ranking of the top 2 diseases was the same for the total respondents. Ranking of diseases 3 through 5 varied when these criteria were taken into consideration.

Animals↗
PubMed1991

Annual disease incidence in Colorado cow-calf herds participating in rounds 2 and 3 of the National Animal Health Monitoring System from 1986 to 1988.

Thirty-nine and 47 randomly selected Colorado cow-calf operations participated in the National Animal Health Monitoring System (NAHMS) during rounds 2 (October 1986 to September 1987) and 3 (October 1987 to September 1988), respectively. Data on the incidence of disease conditions within each herd were collected by federal and state Veterinary Medical Officers and university veterinarians through monthly visits to the ranches. Annual disease incidence for disease classes and the most frequently reported individual disease conditions were determined and expressed on a per 100 cow basis. The mean annual disease incidences for all diseases in these herds were 48.8 and 47.7 new cases per 100 cows for rounds 2 and 3, respectively. The ranges for herd annual disease incidence were wide in both study years. The enteric disease class had the highest mean annual disease incidence in both years of the study, and this was primarily because of diarrhea of unknown cause in calves. Diarrhea of unknown cause accounted for approximately 25% of all new disease cases in both rounds of the study. The mean annual disease incidences were not different for any disease class between the two rounds. The data indicate that, on the average, diarrhea of unknown cause, pneumonia, dystocia, foot rot (interdigital necrobacillosis), pinkeye (infectious keratoconjunctivitis), respiratory tract infection, death of unknown cause, and nonpregnancy had the highest incidences in these Colorado beef herds during the study period. However, because of the wide variation of the predominant disease problems between herds, a herd's disease history as well as the common disease problems in the geographic area of a herd must be considered in designing a herd health program.

Animals↗
PubMed1991

Annual costs associated with disease incidence and prevention in Colorado cow-calf herds participating in rounds 2 and 3 of the National Animal Health Monitoring System from 1986 to 1988.

Thirty-nine and 47 randomly selected Colorado cow-calf operations were monitored for health events and their associated costs during rounds 2 and 3, respectively, of the National Animal Health Monitoring System (NAHMS). Data were collected from each operation for a one-year period by NAHMS veterinarians through monthly interviews, and the costs associated with the incidence and prevention of disease conditions were determined and expressed on a per cow basis. The beef producers involved in this study spent an average of $32.75 per cow in round 2 and $40.97 per cow in round 3 on an annual basis for the treatment of disease conditions. These costs were not different between the 2 rounds because of the wide ranges in the individual herd costs for disease incidence in each round. In both years of the study, the largest contributor to the total mean annual cost of disease incidence was the cost of death of diseased animals, and this cost accounted for approximately two-thirds of the total mean annual cost in each round. The total mean annual costs of disease prevention in these herds were $11.24 and $11.19 per cow in rounds 2 and 3, respectively. There were wide ranges in both rounds in the amounts of money spent per cow by individual herds for disease prevention. The largest individual cost of disease prevention in each year was the cost of vaccines/drugs, whereas the smallest individual cost in each round was the cost of veterinary services.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1991

Expenditures for veterinary services and other costs of disease and disease prevention in 57 California beef herds in the National Animal Health Monitoring System (1988-1989).

Data on costs associated with episodes of disease and disease prevention, including expenditures for veterinary services, were collected from 57 California beef cow-calf herds during 1988-1989 as part of the National Animal Health Monitoring System. Mean cost associated with episodes of disease was $33.90/cow-year, with $0.78 and $1.37/cow-year being spent for veterinary services and drugs, respectively. The highest cost for veterinary services related to episodes of disease were for dystocia, lameness, and ocular carcinoma. For disease prevention, mean expenditures for veterinary services were $1.67/cow-year, nearly all of which was spent on prevention of reproductive tract conditions. Preventive expenditures for veterinary services related to female infertility (pregnancy examination), vaccination against brucellosis and male infertility (breeding soundness examination) were $0.72, $0.39, and $0.22/cow-year, respectively. Many costs associated with episodes of disease and disease prevention were similar to those reported from Colorado National Animal Health Monitoring System beef herds.

Agriculture↗
PubMed1991

Multivariable prediction model for the need for surgery in horses with colic.

A survey of 1,965 equine colic cases was conducted from August 1985 to July 1986 at 10 equine referral centers located throughout the United States. The purpose of this study was to develop and validate a multivariable model for the need for surgery. Two-thirds of the cases were randomly selected for model development (1,336), whereas the remaining cases (629) were used only for subsequent validation of the model. If a lesion requiring surgical correction was found at either surgery or necropsy, the case for the horse was classified as surgical, otherwise the case was classified as medical. Only variables that were significant (P less than 0.05) in an initial bivariable screening procedure were considered in the model development. Because of the large number of missing values in the data set, only variables for which there were less than 400 missing values were considered in the multivariable analysis. A multivariable logistic regression model was constructed by use of a stepwise algorithm. The model used 640 cases and included variables: rectal findings, signs of abdominal pain, peripheral pulse strength, and abdominal sounds. The likelihood ratio for surgery was calculated for each horse in the validation data set, using the logistic regression equation. Using Bayes theorem, the posttest probability was calculated, using the likelihood ratio as the test odds and the prevalence of surgery cases (at each institution) as an estimate of the pretest odds. A Hosmer-Lemeshow goodness-of-fit chi 2 statistic indicated that the model fit the validation data set poorly, as demonstrated by the large chi 2 value of 26.7 (P less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1990

P values.

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Animals↗
PubMed1990

Epidemiologic study of salmonellae shedding in the feces of horses and potential risk factors for development of the infection in hospitalized horses.

A study was designed to identify epidemiologic factors associated with the development and spread of salmonellae in horses in a veterinary teaching hospital, through a case-control study and a longitudinal follow-up prospective study. In the case-control study, 44 horses shedding salmonellae in feces were compared with 99 control horses not shedding salmonellae in feces; regarding breed, sex, age and initial diagnosis, none of the odds ratios for study factors was significant. The factors found to be associated with fecal shedding of salmonellae in the prospective study included diarrhea at the time of admission to the hospital, fever while hospitalized, and a change in diet while hospitalized. Horses identified to be shedding salmonellae in feces were not limited to those with clinical signs of salmonellosis; however, spread of salmonellae from a shedder without clinical signs of disease to other hospitalized horses was not identified. The most common serovars of Salmonella isolated were oranienburg and newport.

Animals↗
PubMed1990

Eperythrozoon wenyonii infection in dairy cattle.

Approximately 10 of 100 young heifers that had recently delivered their first calf--members of a large Colorado dairy herd--had a syndrome of swollen teats and distal portions of the hind limbs, prefemoral lymphadenopathy, transient fever, rough coat, decreased milk production, and subsequent weight loss and reproductive inefficiency. Acute clinical signs of disease were associated with large numbers of Eperythrozoon wenyonii seen on blood smears, and resolution of signs correlated with reduction or disappearance of the parasite. Other known causes of peripheral edema could not be documented. The parasite was transmitted to 4 of 7 nonlactating dairy cows destined to be culled and a splenectomized calf via IV inoculation of blood from parasitemic heifers, but clinical signs of infection were not induced.

Anaplasmataceae Infections↗
PubMed1990

Chlorinated hydrocarbon insecticides in Colorado beef cattle serum--a pilot environmental monitoring system.

A pilot project was initiated to test an existing animal disease surveillance system for use in monitoring environmental pollutants. Eleven chlorinated hydrocarbon insecticides were assayed to provide an indication of environmental contamination. A total of 241 bovine serum samples from 53 Colorado beef ranches was tested; 123 samples (51%) were found to contain detectable concentrations of 1 or more of 11 chlorinated hydrocarbons. There were a total of 203 occurrences of a compound being found at a level exceeding the detection limit. Heptachlor, heptachlor epoxide, lindane, and oxychlordane were the insecticides detected most frequently in bovine sera. This pilot study supports the use of domestic food-producing animals as sentinels of environmental contamination with insecticides.

Animals↗
PubMed1990

Management practices and their association with reproductive health and performance in Colorado beef herds.

An observational study was conducted to quantify the effects of management practices on reproductive performance and disorders of beef cows. The study population consisted of 44 randomly selected Colorado cow-calf herds monitored for disease and reproductive events as part of the National Animal Health Monitoring System. The managers of the herds were surveyed with a standardized questionnaire to determine specific management characteristics of their operations. Data were analyzed using the random-effects multiple logistic regression model. Outcomes of interest were calving rate, herd incidence rates of dystocia and combined reproductive disorders, and calf mortality rate. A higher calving rate was associated (P less than .01) with a decreased percentage of replacement females in the herd, a shorter breeding season, a smaller herd size, and a lower percentage of bulls being used as yearlings. Incidence rates of both dystocia and combined reproductive disorders were found to be lower (P less than .01) in herds that were fed cottonseed cake as a winter supplement, but higher (P less than .01) in herds that were fed grass hay as a winter supplement. Herds located in the mountains of Colorado had lower (P less than .01) incidence rates of dystocia and reproductive disorders than herds located in the eastern plains. Calf mortality rate was found to be higher (P less than .05) with calving seasons that began earlier in the year. Higher calf mortality rates were associated (P less than .05) with an increased incidence of dystocia, the commingling of cattle on summer range, and smaller herd size.

Animal Feed↗