Biomedical subjects

M D Szymanski

Publications and source records attributed to M D Szymanski.

8 recordsLinked to original sources

PubMed2001

Magnetic source imaging of late evoked field responses to vowels: toward an assessment of hemispheric dominance for language.

OBJECT: The goal of this study was to determine whether the late neuromagnetic field elicited by simple speech sounds, which is detected by magnetoencephalography, may be used to estimate hemispheric dominance for language and to guide or constrain the intraoperative search for essential language sites. If sufficiently robust, a noninvasive method for assessing hemispheric dominance for language could reduce the necessity for amobarbital testing and the extent of intraoperative cortical stimulation-based mapping, both of which carry the risk of morbidity. METHODS: Fifteen patients undergoing surgery for tumors during which intraoperative language mapping would be performed and two additional patients in whom intracarotid amobarbital testing confirmed right-hemisphere language dominance participated. Following a primary auditory response sources of late neuromagnetic fields elicited by vowel stimuli were modeled and coregistered using magnetic resonance images to form magnetic source (MS) images. A laterality index (LI) was calculated by summing the number of equivalent current dipolar sources in the late fields detected from each hemisphere. In 14 right-handed patients, 10 displayed left asymmetric LIs (0.37 +/- 0.16. mean +/- standard error of the mean in 14 patients). For both right-hemisphere dominant patients in whom an LI was obtainable, the LI was rightward. Stimulation-mapped essential language sites were found in 7 of 15 patients. For six of these seven patients, the MS image-derived LI was leftward. CONCLUSIONS: Asymmetry in single equivalent dipole modeling of the late neuromagnetic field evoked by simple speech sounds correlates with hemispheric language dominance, although not to the degree necessary for individual clinical predictions. With further development, MS imaging of simple language tasks may be used preoperatively to predict language dominance and even to identify or constrain the intraoperative search for likely sites of essential language cortex.

Acoustic Stimulation↗

PubMed1999

A hemispherically asymmetrical MEG response to vowels.

Neuromagnetic fields elicited by vowels and tones were recorded and sources were modeled as single equivalent current dipoles (ECDs) in 1 ms steps 80-400 ms post stimulus. To vowels, the left hemisphere (LH) auditory cortex had nearly twice as many satisfactory ECD fits as the right hemisphere (RH). Tones did not evoke such asymmetry. In particular, in the late field (150-400 ms) the LH had more than twice as many ECDs as the RH, and the spatial distribution of LH sources was more clustered than in the RH. An asymmetrical, focal cortical mechanism for vowel processing was identified that intensified in later auditory processing stages. These data suggest that MEG might be used for non-invasive, language laterality determination with simple vowel-like stimuli.

Adult↗

PubMed1999

Human brain specialization for phonetic attention.

The effects of auditory selective attention on event related potentials (ERPs) to speech sounds were examined in subjects attending to vowel-consonant-vowels (VCVs) in one ear while ignoring VCVs in the opposite ear. In one condition, subjects discriminated phonetic changes in the VC, CV, or both formant-transition regions. In another condition, they discriminated equally difficult intensity changes in the same VCV regions. Attention-related negative difference waves showed enhanced early and late components (Nde and Ndl) during phoneme-discrimination conditions. Hemispheric asymmetries developed only during the Ndl and were more pronounced during phoneme discrimination. The results suggest that auditory areas of both hemispheres are specialized for phonetic analysis, with hemispherically specialized mechanisms engaged primarily during the final stages of phoneme processing.

Adult↗

PubMed1999

Killer whale (Orcinus orca) hearing: auditory brainstem response and behavioral audiograms.

Killer whale (Orcinus orca) audiograms were measured using behavioral responses and auditory evoked potentials (AEPs) from two trained adult females. The mean auditory brainstem response (ABR) audiogram to tones between 1 and 100 kHz was 12 dB (re 1 mu Pa) less sensitive than behavioral audiograms from the same individuals (+/- 8 dB). The ABR and behavioral audiogram curves had shapes that were generally consistent and had the best threshold agreement (5 dB) in the most sensitive range 18-42 kHz, and the least (22 dB) at higher frequencies 60-100 kHz. The most sensitive frequency in the mean Orcinus audiogram was 20 kHz (36 dB), a frequency lower than many other odontocetes, but one that matches peak spectral energy reported for wild killer whale echolocation clicks. A previously reported audiogram of a male Orcinus had greatest sensitivity in this range (15 kHz, approximately 35 dB). Both whales reliably responded to 100-kHz tones (95 dB), and one whale to a 120-kHz tone, a variation from an earlier reported high-frequency limit of 32 kHz for a male Orcinus. Despite smaller amplitude ABRs than smaller delphinids, the results demonstrated that ABR audiometry can provide a useful suprathreshold estimate of hearing range in toothed whales.

Animals↗

PubMed1999

Phonemes, intensity and attention: differential effects on the mismatch negativity (MMN).

Auditory event-related potentials (ERPs) to speech sounds were recorded in a demanding selective attention task to measure how the mismatch negativity (MMN) was affected by attention, deviant feature, and task relevance, i.e., whether the feature was target or nontarget type. With vowel-consonant-vowel (VCV) disyllables randomly presented to the right and left ears, subjects attended to the VCVs in one ear. In different conditions, the subjects responded to either intensity or phoneme deviance in the consonant. The position of the deviance within the VCV also varied, being in the first (VC), second (CV), or both (VC and CV) formant-transition regions. The MMN amplitudes were larger for deviants in the attended ear. Task relevance affected the MMNs to intensity and phoneme deviants differently. Target-type intensity deviants yielded larger MMNs than nontarget types. For phoneme deviants there was no main effect of task relevance, but there was a critical interaction with deviance position. The both position gave the largest MMN amplitudes for target-type phoneme deviants, as it did for target- and nontarget-type intensity deviants. The MMN for nontarget-type phoneme deviants, however, showed an inverse pattern such that the MMN for the both position had the smallest amplitude despite its greater spectro-temporal deviance and its greater detectability when it was the target. These data indicate that the MMN reflects differences in phonetic structure as well as differences in acoustic spectral-energy structure of the deviant stimuli. Furthermore, the task relevance effects demonstrate that top-down controls not only affect the amplitude of the MMN, but can reverse the pattern of MMN amplitudes among different stimuli.

Adult↗

PubMed1996

Signal-detection, threshold, and dual-process models of recognition memory: ROCs and conscious recollection.

Threshold- and signal-detection-based models have dominated theorizing about recognition memory. Building upon these theoretical frameworks, we have argued for a dual-process model in which conscious recollection (a threshold process) and familiarity (a signal-detection process) contribute to memory performance. In the current paper we assessed several memory models by examining the effects of levels of processing and the number of presentations on recognition memory receiver operating characteristics (ROCs). In general, when the ROCs were plotted in probability space they exhibited an inverted U shape; however, when they were plotted in z space they exhibited a U shape. An examination of the ROCs showed that the dual-process model could account for the observed ROCs, but that models based solely on either threshold or signal-detection processes failed to provide a sufficient account of the data. Furthermore, an examination of subjects' introspective reports using the remember/know procedure showed that subjects were aware of recollection and familiarity and were able to consistently report on their occurrence. The remember/know data were used to accurately predict the shapes of the ROCs, and estimates of recollection and familiarity derived from the ROC data mirrored the subjective reports of these processes.

Adult↗

PubMed1991

Latency and amplitude compound action potential tuning curves for tonal stimuli with nontraditional envelopes.

To evaluate the influence of the acoustic context on the latency and amplitude tuning curves (TCs) of cochlear nerve compound action potentials (CAPs), tonal stimuli were generated with a variety of amplitude modulation envelopes. CAPs were produced by intensity increases (onsets) and decreases (offsets) from the low ambient sound level and by intensity changes from a preexisting tonal level. Onset CAPs from ambient levels generated V-shaped TCs. However, when simultaneous masking was used with onset CAPs which were produced by a 5- to 12-dB increase from preexisting levels of approximately 65 dB SPL, TCs were W-shaped and similar in appearance to those produced by simultaneous masking of offset CAPs. The forward masking of this same CAP resulted in a very sharp V-shaped TC. These data suggest that the preadaptation to 10 ms of a moderate level of a tonal stimulus can increase the tuning of ensembles of cochlear neurons to subsequent transient amplitude changes.

Acoustic Stimulation↗

PubMedDate not supplied

Albino and pigmented gerbil auditory function: influence of genotype and gentamicin.

Auditory function of albino and pigmented gerbils was examined before and after treatment with the ototoxic aminoglycoside antibiotic gentamicin. Auditory brainstem responses (ABRs) and cochlear nerve compound action potentials (CAPs) were measured in response to pure tones having frequencies between 2 and 32 kHz. Age-matched albinos had significantly lower CAP, but not ABR, thresholds than pigmented gerbils. Gentamicin treatment elevated CAP and ABR thresholds in both genotypes, but pigmented gerbils were less severely affected. Compared to the ABR, the CAP is a more sensitive measure of ototoxicity and pigmentation differences. CAP tuning curves (TCs) were another sensitive measure of genotypic differences in susceptibility to ototoxicity. TC tip thresholds from pigmented animals given gentamicin were not as elevated as the TC tip thresholds of albinos.

Animals↗