PubMed Health⌕ Search

Biomedical subjects

M D Tasch

Publications and source records attributed to M D Tasch.

10 recordsLinked to original sources
PubMed1988

The autonomic nervous system and geriatric anesthesia.

Patients subjected to surgery and anesthesia must rely on autonomic mechanisms to maintain homeostasis and adequate organ perfusion. In the elderly, many of these mechanisms are limited in the strength, the rapidity, and the range in which they can compensate for physiological stresses and trespass. Anesthesiologists rely on predictable results from manipulation of the ANS and its effector organs, but aging in itself seems to alter the responses to these pharmacological manipulations. The diseases and medications that often accompany old age are further confounding factors. Some of the changes found with age seem to arise from the ANS itself, while some more likely originate in structural alterations of the cardiovascular system. Although both basic and clinical research reports are rife with contradictions, a knowledge of ANS aging should help us to anticipate the particular responses and requirements of our older patients.

Aged↗
PubMed1986

Effects of cimetidine and ranitidine on local anesthetic central nervous system toxicity in mice.

The effects of cimetidine (5-200 mg/kg), ranitidine (1-100 mg/kg), or saline on local anesthetic central nervous system toxicity was studied when administered 20 min before the administration of lidocaine (30-80 mg/kg) or 2-chloroprocaine (50-250 mg/kg) to female white CD-1 mice. All drugs were administered intraperitoneally. The 50% convulsive dose (CD50) was determined for each drug and dose combination. Pretreatment with cimetidine resulted in a significant, dose-dependent decrease in the CD50 of lidocaine, whereas ranitidine pretreatment did not significantly alter the lidocaine CD50. A dose of cimetidine (15 mg/kg) that caused a significant decrease in 2-chloroprocaine CD50 (from 180 to 110 mg/kg) caused only an insignificant decrease in lidocaine CD50 (from 59 to 54 mg/kg). If these results can be applied to clinical doses in humans, ranitidine may be a safer premedicant than cimetidine with regard to interactions with local anesthetics.

Anesthetics, Local↗