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Biomedical subjects

M D Winton

Publications and source records attributed to M D Winton.

3 recordsLinked to original sources

Antimicrobial therapy for CAPD-associated peritonitis.

Infectious peritonitis continues to be the leading cause of morbidity in patients on continuous ambulatory peritoneal dialysis (CAPD). Optimum management of CAPD-associated peritonitis requires a concerted effort toward the establishment of the specific agent causing the episode. We have reviewed the current literature relating to the diagnosis and institution of antimicrobial therapy. Controlled comparative trials are needed to determine the efficacy of potentially less toxic therapeutic regimens for peritonitis, for definition of and treatment of exit-site infections, and timing of catheter replacement.

Anti-Infective Agents↗

Activities of five new fluoroquinolones against Pseudomonas pseudomallei.

Thirty-four isolates of Pseudomonas pseudomallei were tested by a broth microdilution technique for susceptibility to amifloxacin, ciprofloxacin, enoxacin, norfloxacin, and ofloxacin. Ciprofloxacin was the most active agent tested, with an MIC for 90% of the strains tested of 8 micrograms/ml. These in vitro results suggest that the fluoroquinolones tested would not be optimal for therapy of melioidosis.

Anti-Bacterial Agents↗