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Biomedical subjects

M D Zhang

Publications and source records attributed to M D Zhang.

10 recordsLinked to original sources
PubMed1992

[Aflatoxins and primary liver cancer--a population based case-control study].

A case-control study of primary liver cancer (PLC) was conducted in 1989 at Fusui County, Guangxi Province. There were 99 PLC cases and 99 age-sex-residence matched controls. There were no difference of age, sex, race, cultural, level, marital status and annual income distribution (P > 0.05). The mean dietary AFB1 intakes of cases and controls were 117.72 + 105.68 mg/d, the mean outputs of AFM1 were 22.56 and 21.62 ng per morning urine respectively. The mean sera aflatoxin-albumin adducts in both groups were 24.96 and 18.72 pg per mg albumin respectively. These indicators were of no statistical significance. Conditional Logistic regression showed that HBV infection (OR = 5.33), drinking pond-ditch water (OR = 3.70), family history of PLC (OR = 2.88), and total alcohol intakes (OR = 1.002) were statistically significant as risk factors (P > 0.05) rather than aflatoxins. This may be due to the fact that the samples selected in hyperendemic area both took high quantities of aflatoxin.

Aflatoxin B1↗
PubMed1991

[An immunological study of endogenous uveitis: changes in peripheral blood T-cell subsets and their transformation rate].

Dynamic changes of peripheral blood T-cell subsets and their transformation rate were studied in 77 cases of EU. The results showed that the percentages of T3+ and T4+ cells, and the T4+/T8+ ratio decreased, while the percentage of T8+ cells increased, and the T-cell transformation rate was significantly lowered. The immunofunctional changes in chronic anterior uveitis and pan-uveitis were particularly remarkable. The findings indicated that abnormal T-cell subsets and the reduced cell-mediated immunofunction played an important role in the pathogenesis of EU.

Adolescent↗
PubMed1991

[Immunological study of endogenous uveitis. I. Dynamic study of autoimmunoreaction].

The autoimmunoreaction was determined with pig eye antigen and bovine retinal soluble antigen (S-Ag) in 77 patients with endogenous uveitis (EU) and 100 healthy individuals. The results showed that lymphocytes of 6 (35.3%) of 17 patients with EU reacted to bovine S-Ag, while those of all 10 healthy subjects were negative. The positivity and titers of serum autoantibodies in the patients with EU were significantly higher than in the healthy subjects and was also related to the activity of EU. These data suggested that the S-Ag sensitized lymphocytes played an important role in the pathogenesis of pan-uveitis, and the serum autoantibodies were significant in the aggravation of EU.

Adolescent↗
PubMed1991

[An immunological study of endogenous uveitis: circulating immune complexes and their specific characteristics].

The levels of circulating immune complexes (CIC) in 77 patients with endogenous uveitis (EU) were found significantly higher than in healthy controls, and also closely correlated with activity of the disease. The CIC level declined during remission and became essentially normal when the disease recovered. CIC was positive in 20 (37.7%) of the 77 cases, and the positive rate was the highest (58.6%) in patients with acute EU. Retinal soluble antigen was found in CIC of 9 patients. The serum C3 level was in negative correlation with the CIC level, and restored to normal on recovery of the disease. The findings indicated that CIC played an important role in the pathogenesis of EU.

Adolescent↗
PubMed1990

Hepatitis delta virus superinfection in Guangzhou area.

Biopsy and autopsy specimens of liver tissues of two series of patients, one of adults and the other children suffering from hepatitis B virus (HBV) infection were used to evaluate hepatitis delta virus antigen (HDAg) by direct immunoperoxidase staining method. The results showed that four HDAg positive cases were found among 30 cases of HBV infected adult patients (13.3%), and 6 were found in 44 cases in the children series (13.6%). Therefore, we are convinced that hepatitis delta virus (HDV) superinfection does exist in Guangzhou area. The superinfection rates in adults and children are almost identical.

Adult↗
PubMed1989

Clinical phenomenology of mental disorders caused by Qigong exercise.

One hundred and nine patients with mental disorders caused by Qigong psychophysical exercise deviation are studied. These patients were divided into schizophrenic type (47 cases) and neurotic type (62 cases) and were analyzed by standard psychiatric rating scales and improved Minnesota multiphasic personality inventory (MMPI). The results show that patients with Qigong deviation presented abnormalities in perception, thinking, and behavior of varying degree. The clinical characteristics could not be classified into extent psychiatric disease units. Most of these patients manifested specific physical symptoms of Qigong deviation. The authors suggest that this kind of mild, benign mental disorder associated with the unique culture of our country be studied to contribute to the study of the classification of mental disorders. Qigong triggered disorders usually normalized during short term follow-up.

Adolescent↗