PubMed Health⌕ Search

Biomedical subjects

M DAVIS

Publications and source records attributed to M DAVIS.

At least 19 recordsLinked to original sources
PubMed1959

The schistosomicidal and toxic effects of some N-p-aminophenoxyalkylamides.

Several N-(omega-p-aminophenoxyalkyl)amides were active against Schistosoma mansoni in mice. One of the most effective, N-(5-p-aminophenoxypentyl)benzamide (M&B3002), acted more rapidly than lucanthone on adult worms but less rapidly than antimony potassium tartrate. It was inactive against immature worms. This compound and M&B2948A (N-(5-p-aminophenoxypentyl)phthalimide) were both active against S. mansoni in hamsters. In monkeys M&B2948A was inactive, whilst M&B3002 was not tested for therapeutic activity. Several of the compounds were examined for the production of visual impairment in cats. Although this property was not entirely absent, its incidence was very much lower in this amide series than among other omega-p-aminophenoxyalkyl derivatives not containing an amide group. M&B3002 and M&B2948A produced impairment of vision in only a small proportion of the large number of cats tested. The general toxicology of the two drugs was studied in several species, and also their absorption and excretion in mice and rats; this was to provide information for a clinical trial.

Amides↗
PubMed1958

The schistosomicidal and toxic effects on some alphaomega-di (p-aminophenoxy)alkanes and related monoamines.

An account is given of the results obtained with a number of p-aminophenoxyalkanes which were examined for activity against Schistosoma mansoni in mice and for the presence of retinotoxicity in cats. The first compound to be found active, 1:5-di(p-aminophenoxy)-pentane dihydrochloride (M & B 968A), was modified in a variety of ways in an attempt to increase its activity and to eliminate its ocular effects. It was found that a p-aminophenoxyalkyl group was common to all the active compounds, but that the rest of the molecule could be any of several different groups, including alkoxy, phenoxy, and phenyl groups, without diminishing the activity. Although at least one p-aminophenoxyalkyl group was essential for schistosomicidal activity, ocular toxicity was also shown by a p-aminophenylalkyl derivative in which the ether linkage was absent.

Alcohols↗