Biomedical subjects
Publications and source records attributed to M Dabrowska.
A number of derivatives of the L-lysine peptides has been obtained and their antibacterial properties were evaluated and compared with those of the ethyl ester of Nalpha-palmitoyl-L-lysyl-L-lysine dihydrochloride. Some correlations have been found between the chemical structure and antibacterial activity of the compounds.
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In twenty four patients diagnosed with Hodgkin's disease we have determined several antiproteases. Our findings have shown the decrease of concentration of alpha-2-macroglobulin and increase of alpha-1-proteinase inhibitor and alpha-1-antichymotrypsin. The observed changes were statistically significant p < 0.001. We did not find any correlation between the concentration of inhibitors and the clinical stage of carcinoma and histopathological data. The determination of the level of antiproteases in patients with cancer disease may be assumed to reflect partly at least the capability of anticancer mechanism in the host.
Six met-enkephalin derivatives substituted in position 4 with D-4-chlorophenylalanine or D-4-fluorophenylalanine were obtained. Their antinociceptive activity was determined after icv administration to rats by tail immersion test. Cataleptic activity and the influence of the analogs obtained on the body temperature were also estimated. All compounds exerted analgesic activity, which was decreased significantly by naloxone. Almost all compounds appeared cataleptic, some of them caused hypothermia.
The maintenance of equilibrium between proteases and their inhibitors has substantial significance for the pathogenesis of the neoplastic disease. It concerns especially the invasiveness of the neoplasms, which increases with rising of the proteases activity or with the decrease of the inhibitory activity of antiproteases. The neoplastic cell has the faculty of producing numerous proteases which by damaging connective tissue facilitates the invasion by the neoplasm. Invasiveness of the neoplasms may be augmented by the production of proteases by the host cells stimulated by the neoplasm. The condition of the proteases--antiproteases balance is also influenced by the production of antiproteases by neoplastic cells. Among numerous antiproteases alpha-2-macroglobulin has most intensive cytotoxic action in relation with the neoplasm. According to data collected from the literature, antiproteases can be regarded as anticarcinogenic agents. On account of this, the estimation of the antiproteases level can be regarded as a measure of the ability of the body system to resist the invasiveness of neoplasms.