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Biomedical subjects

M Dabska

Publications and source records attributed to M Dabska.

At least 19 recordsLinked to original sources

Estrogen receptor in human breast cancer in relation to tumor morphology and endocrine therapy.

The presence of estrogen receptors (ER) was determined in 111 human breast cancer specimens. In 61% of the tumors, specific estrogen binding was found and in 39% of the tumors ER was absent. In 69 tumors no correlation was found between the histological grading of the tumor and the level of ER. The values of ER in tumors from patients over 50 years of age were usually much higher than those for patients under 50 years of age. Different methods of endocrine therapy were applied in 20 patients. In 10 of 15 patients with ER positive tumors, endocrine therapy resulted in remission. Only 1 of 5 patients with ER negative tumors responded with remission. It is concluded that estimation of ER in tumor tissue is helpful in the selection of patients for endocrine therapy.

Adult

Parachordoma: a new clinicopathologic entity.

Parachordoma is a tumor that was established and described by Laskowski in 1951. It is a rare tumor, which appears adjacent to tendons, synovium, and even osseous structures. It is lobular and pseudoencapsulated. Histologically, in some ways, it is compatible with the chordomas of bone with a constant fibrous tissue component. It grows slowly and is only locally invasive. If not adequately excised, it is prone to recur, but complete surgical removal is usually possible. Its exact histogenesis remains obscure. This tumor may have some relationship to the great vesicular cells of chordoid tissue described by Schaffer as "blasige Zellen von chordoiden Gewebe" developing from special synovial cells. Ten cases collected over a period of 26 years at the Institute of Oncology in Warsaw are presented.

Adolescent

Histochemical features of C-cell thyroid carcinoma.

Six cases of C-cell carcinoma of thyroid gland were studied applying histologic and histochemical methods as well as electron microscopy technique. A histologic feature of the carcinoma pattern was the diversity of pictures. Amyloid was commonly found in the carcinoma stroma. In some cells glycogen was present. Histochemically the carcinoma cells were marked by a strong activity of oxidative enzymes (GDH, SDH, LDH and MAO) as well as hydrolitic one (G-6-P and non specific enterases). Serotonin was found in two cases. An ultrastructural feature of carcinoma cells was the presence of cytoplasmic electron-dense, specific "endocrine type" secretory granules.

Amyloid

Usefulness of drill biopsy in the diagnosis of breast tumors.

A retrospective study was undertaken to analyze the usefulness of 600 drill biopsies taken from 557 breast tumors. Based on the first biopsy, the malignant or benign nature of the tumor was accurately estimated in 93.6% of the cases. A diagnosis of cancer was established microscopically in 87.4% of the tumors. In our opinion, this method proved to be valuable and is recommended for outpatient clinics.

Biopsy

[Liposarcoma].

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Aged

[Angiosarcoma].

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Adolescent