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Biomedical subjects

M Dan

Publications and source records attributed to M Dan.

At least 127 records · Page 7Linked to original sources
PubMed1988

The epidemiology of shigellosis in Israel.

Analysis of Shigella isolates referred for serotyping to the Central Shigella Reference Laboratory has revealed a slight predominance of S. sonnei (47%) over S. flexneri (44%) in Israel. In female patients, the predominance of S. sonnei isolates was more accentuated (54 v. 37.5% for S. flexneri). On the other hand, an increased incidence of S. flexneri was observed in military personnel (59 v. 32% for S. sonnei), and even more so in the Arab population (69 v. 19%). Incidence peaked in summer (July, August) for all subgroups.

Dysentery, Bacillary↗
PubMed1987

Bacteremic hypocalcemia. A comparison between the calcium levels of bacteremic and nonbacteremic patients with infection.

Hypocalcemia has been documented in critically ill patients, including those with sepsis and shock. However, its incidence and significance in bacteremic patients without shock has not been established. In the present study the presence of hypocalcemia was evaluated in a group of 67 consecutive bacteremic patients, as compared with 64 infected but nonbacteremic patients. After correction of serum calcium level for serum protein, 25 of the bacteremic patients (37.3%) had "corrected" hypocalcemia (less than 8.5 mg/dL [2.12 mmol/L]), compared with only three in the nonbacteremic group (4.5%). The incidence and magnitude of hypocalcemia in gram-positive and gram-negative infections was similar. In hypocalcemic patients, the "corrected" calcium level was found to be inversely correlated with day of disease and attained a nadir on day 6 to 8 of bacteremia. This nadir was significantly lower in male than in female subjects. Hypocalcemic patients had a significantly higher maximal temperature than normocalcemic ones, but hypocalcemia was unrelated to serum levels of albumin, transaminase, and creatinine.

Aged↗
PubMed1987

Concentrations of ciprofloxacin in human liver, gallbladder, and bile after oral administration.

We have measured concentrations of ciprofloxacin in serum, hepatic tissue, gallbladder, and bile in 10 patients after a single oral dose of 750 mg given before cholecystectomy. Mean liver and gallbladder tissue concentrations were 12.76 micrograms X g-1 +/- 2.79 (SEM) and 5.94 micrograms X g-1 +/- 1.35, respectively. Concentrations in bile taken from the gallbladder (7 patients) ranged from 68 to 225 micrograms X ml-1, with a mean bile/serum concentration ratio of 49. Concentrations in bile taken from the common bile duct (2 patients) were 17 and 16 micrograms X ml-1.

Administration, Oral↗
PubMed1987

Comparison of an agar slide blood culture device with Bactec 6B for the detection of bacteremia.

Each of 1,018 blood culture specimens was inoculated into Bactec 6B (Johnston Laboratories, Towson, MD) and a biphasic blood culture system that incorporates internal removable agar dip slides (Hylab). Ninety clinically significant pathogens were recovered: 66 from both systems, 14 from Bactec only, and 10 from Hylab only. The mean incubation times to positive of the two systems did not differ when data were examined for gram-negative bacilli, gram-positive cocci, total isolates, and contaminants (P greater than 0.05). Contamination rates were also comparable: Bactec 5.4%, Hylab 7.3% (P greater than 0.05). The Hylab system may offer a practical alternative to Bactec 6B.

Agar↗
PubMed1987

Concentration of norfloxacin in human gallbladder tissue and bile after single-dose oral administration.

Concomitant concentrations of norfloxacin in serum and in gallbladder tissue and bile were determined in 10 patients after a single oral dose of 400 mg given before cholecystectomy. Concentrations in gallbladder bile ranged from 0.6 to 15.6 micrograms/ml, with a mean bile/serum ratio of 7.0. The mean concentration in gallbladder tissue was 1.8 +/- 0.8 (standard error) micrograms/g.

Adult↗
PubMed1987

Isolation of Chlamydia trachomatis from the liver of a patient with prolonged fever.

Chlamydia trachomatis was isolated from liver biopsy specimens on two separate occasions in a young, sexually inactive patient with a 10 month history of recurrent episodes of fever, chills, and abdominal pain. Liver function tests showed a five fold increase in alkaline phosphatase, and a 20 fold increase in 5'-nucleotidase. Liver histology changes consisted of mild inflammatory infiltrates in the portal tracts. Treatment with doxycycline was followed by complete recovery. We are not aware of any previous report describing isolation of this organism from the liver parenchyma, or of C trachomatis infection presenting as fever of obscure origin.

Adolescent↗
PubMed1986

Mixed bacterial subdural empyema complicating subdural peritoneal shunt.

Bilateral subdural empyema occurred in a nine-month-old boy with a subdural-peritoneal shunt. Because of the mixed composition of bacterial growths, representative of faecal flora, it is assumed that the infection originated from perforation of the bowel by the distal tip of the shunt catheter, although no abnormal abdominal signs or symptoms were noted.

Anti-Bacterial Agents↗
PubMed1986

Concentration of ciprofloxacin in human prostatic tissue after oral administration.

Concomitant concentrations of ciprofloxacin in serum, urine, and prostatic tissue were determined in 15 patients after single oral doses of 750 mg. Levels in tissue ranged from 0.6 to 4.18 micrograms/g, and therapeutic concentrations were demonstrable for up to 9 h after administration. The mean ratio of tissue to serum concentration was 0.93 +/- 0.08 (standard error).

Administration, Oral↗
PubMed1986

Influence of patient hemogram on growth index values generated from a radiometric detection device.

Blood samples from 20 patients with widely varying concentrations of erythrocytes and leukocyte subtypes were inoculated into BACTEC 6B bottles (Johnston Laboratories, Inc., Towson, Md.). There was no relationship between growth index value and hemogram. Although sterile blood is capable of generating small amounts of 14CO2, the mechanism for this phenomenon is not related to the concentration of a specific type of blood cell.

Adult↗
PubMed1986

Hypersensitivity pneumonitis induced by nalidixic acid.

Interstitial pneumonitis developed in a patient one week after therapy with nalidixic acid was initiated. The causal association between the drug and the lung disease is based on the temporal relationship, an increased eosinophil count in both peripheral blood and fluid obtained by bronchoalveolar lavage, a positive migration inhibitory factor test with nalidixic acid, and exclusion of other causes. This is, to the best of our knowledge, the first report of a pulmonary hypersensitivity reaction to nalidixic acid.

Aged↗