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Biomedical subjects

M Dana

Publications and source records attributed to M Dana.

At least 19 recordsLinked to original sources
PubMed1985

[Supratentorial glioblastoma in adults. Therapeutic results].

This retrospective study concerns 55 adult patients with supratentorial glioblastoma. The tumours were treated by complete or partial surgical excision whenever possible (31 cases), radiotherapy (22 cases) in doses of 60 Gy over 6 to 7 weeks (40 Gy with telecobalt and 20 Gy with superimposed electrons) and multiple chemotherapy (10 cases) with VM26 and CCNU or BCNU. Although the number of patients in some categories was too small for statistical evaluation, the results obtained were in agreement with those found in the literature and indicative of what can be expected. In patients with inoperable tumours the mean survival was increased from 2 to 8 months by radiotherapy or chemotherapy given separately, and from 2 to 9 or 10 months only when these two methods were combined. The mean survival of patients with partial tumoral excision was 2.5 months extended to 10 months after post-operative radiotherapy; one patient in this group who received both radiotherapy and chemotherapy is still alive after more than 5 years. In patients with macroscopically satisfactory excision, the 12 months good quality survival obtained by surgery was apparently prolonged to 22 months with radiotherapy; 3 of these patients who had both radiotherapy and chemotherapy after surgery are alive and in good condition after 15, 16 and 28 months respectively.

Adult↗
PubMed1984

[An unusual form of neoplastic lymphangitis in an irradiated field].

The authors describe an exceptional form of neoplastic lymphangitis occurring in old people some years after surgery and irradiation of a cancer (parotid, breast), the special character of which is that it draws exactly the fields of irradiation. This lymphangitis is at first smooth and later covered with neoplastic nodes which join together. Evolution is in any case the death after some weeks or months. Different pathogenetic hypotheses are discussed, involving the mechanisms of biology of cancer and radiations.

Aged↗
PubMed1982

[Effects of mantle-field irradiation and chemotherapy on respiratory function (author's transl)].

In 15 patients with mediastinal Hodgkin's disease treated with chemotherapy followed by mantle-field irradiation respiratory function tests performed before and after irradiation showed a decrease in vital capacity and FEV1 as compared with pretreatment values. The decrease was maximum at 4 months and regressed over one year. No significant changes were observed in blood gas measurements. Respiratory symptoms, which were frequent after irradiation, almost completely disappeared within one year. The therapeutic combination had no cumulative adverse effect on respiratory function.

Adult↗
PubMed1981

[Long-term evolution of nodular lymphoma. Outcome in 85 patients treated between 1968 and 1975 (author's transl)].

Eighty-five patients with nodular lymphoma diagnosed between 1968 and 1975 were followed up for long periods and were treated by either conventional methods (local radiotherapy and single drug chemotherapy) or by more intensive therapeutic regimens, such as initial combined M.O.P.P. therapy and maintenance treatment with chlorambucil with or without further courses of M.O.P.P. Long-term follow-ups have brought to light some interesting points concerning the prognosis. Dissemination of the disease and large-cell histological pattern were, as already known, unfavourable factors. Neither age nor sex, nor bone-marrow involvement seemed to have any influence. Obtaining complete remissions improved the prognosis, but intensifying the initial and maintenance treatments proved disappointing: the survival rate remained the same, and the incidence of drug induced leukaemias was high. Indeed, relapses appeared to be less responsive to treatment when the patient had initially received multiple chemotherapy. However, in view of the high death rate of the disease (one-third of the patients in this series died within the first 5 years), trying new therapeutic regimens in the hope of obtaining better results, as has been done in Hodgkin's disease, would be fully justified.

Acute Disease↗
PubMed1981

[Multiple chemotherapy (MOPP) followed by either focal or selective radiotherapy in clinical stages IA and II2A of Hodgkin's disease: results after four years of the use of prospective schedule (H 7701) in 79 patients (author's transl)].

Seventy-nine patients with clinical stages IA, or II2A of Hodgkin's disease were treated from January 1977 to April 1980 by a multiple therapy schedule, H 7701. Three courses of MOPP chemotherapy were first given to all patients. They were then randomly allocated to two groups: group 7701 S (38 patients) was treated by mantle irradiation, excluding the mediastinum when this was not initially involved, or inverted Y radiotherapy; group 7701 F (41 patients) was treated by focal irradiation only. After follow-up for 9-48 months (median: 26 months), overall survival was 98,6 p. cent and relapse-free duration 94,9 p cent. No statistical difference exists between the two randomized groups. Four patients relapsed; three are now free of disease after further treatment, while one patient has since died. With this chemotherapy-radiotherapy selective of focal sequence, staging laparotomy is not indicated. Results and side effects of this treatment schedule are compared with those of other treatment strategies.

Adolescent↗
PubMed1980

[Radiotherapy of basal cell epitheliomas of the face (author's transl)].

Great advances have been made in the techniques used for radiotherapy, both in safety measures to avoid accidents due to dosage errors, and by the use of new rays such as electrons from accelerators which permit more selective irradiation avoiding surrounding tissues. The authors discuss the indications for the different radiotherapy methods used in basal cell epitheliomas of the face, when compared with or used in association with other procedures such as operative therapy, in relation to the characteristics of the tumor, its proximity to delicate organs, the age of the patient. The possible esthetic and functional sequelae, and the cost to society.

Basal Cell Carcinoma↗
PubMed1979

[Possibilities of radiation-dose reduction in the treatment of Hodgkin's disease. I. Exclusion of the mediastinum from the radiation field in primary high-cervical or infradiaphragmatic involvement and stage I or II (author's transl)].

A retrospective analysis on 482 patients with localised Hodgkin's disease revealed that none of those with primary high-cervical or primary infradiaphragmatic involvement had any infiltration of the mediastinum, either at the time or later. As a result, prophylactic mediastinal radiation was not practised if high-cervical or infradiaphragmatic lymph-nodes had been affected first. None of these patients had any mediastinal recurrence after at least seven years.

Adolescent↗
PubMed1979

A case of fibrous hamartoma of infancy.

An instance of fibrous hamartoma of infancy (FHI) in the perianal region of an 8-mo-old infant, a hitherto unreported location, is described. The majority of the reported cases occur in the torso and upper extremities. The differential diagnostic features which aid differentiating FHI from other conditions is discussed. Although the tumor may recur after excision, a conservative surgical management appears adequate since all reported cases ultimately have proven to have an excellent prognosis.

Anus Neoplasms↗
PubMed1979

[Results of the radiotherapy in the non Hodgkin's lymphomas treatment (author's transl)].

In our 98 patients all treated by association chemotherapy + cobaltherapy, 37 cases were stages III and IV and 71 cases were of diffuse pathology classification. Meanwhile the results were not so poor: 66% at 5 years survival (all stages) and 69% for stages I and II. The curves of survival rate generally stabilize at 7 years. The prognostic depend of the pathology class: diffuse LBS and diffuse HBS have an evolution similar to acute leukemia (44.5% and 19% at 7 years survival), on the opposite nodular LBS, diffuse LCS have 100% survival at 7 years. Diffuse cases have visceral relapses (liver, bone marrow, Waldeyer ring) or generalized lymphatic involvement; nodular cases have generally localized and only lymph-nodes relapses. The best results by large fields irradiation suggest a contiguous extension of the disease, but there is also distant lymph nodes relapses. In the nodular cases, relapses can be generally cured by localized radiotherapy. In the diffuse case, we do not know if it is better to give total lymphnode irradiation (or to give more chemotherapy with economic irradiation). 10 gastro-intestinal cases were treated by moving strip technique with excellent tolerance and 67.5% at 5 years survival. These results show that interesting results may be obtained in non Hodgkin lymphomas by association of chemotherapy, with selective and moderately large fields irradiation, even in disseminated cases, even in diffuse cases.

Antineoplastic Agents↗
PubMed1978

[Treatment of breast carcinoma. Results of telecobaltherapy associated to surgery (author's transl)].

The study was performed on 156 cases of breast carcinoma treated since 1968 with a follow up of 5 to 9 years. The global actuarial survival in 73,5%. The stages T1 T2 N0 treated by tumor excision gave a prominent result: 93% 5 years survival while preserving the breast. Among grave signs the importance of axillar involvement is outlined: the 5 years survival is 65,5% with N1 M0 while 73,5% with N0 - M0. Local recurrences are rare (8%) and generally in extensive cases. Sequelae are rare (3 to 13%), the most frequent is the arm lymphodema which is related more to the Halstedt surgical procedure than to post operative irradiation. These results in agreement with other publications emphasize the importance of post operative irradiation. Only in the high risk cases one must try in addition to radiotherapy a chemotherapy treatment.

Adult↗