Klinefelter's syndrome and hypostatic leg ulceration.
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Adult↗
Biomedical subjects
M Daniel
Publications and source records attributed to M Daniel.
The amino acid sequence of the dihaem cytochrome c4 from the bacterium Azotobacter vinelandii.
An amino acid sequence is proposed for the cytochrome c4 from the bacterium Azotobacter vinelandii strain OP. It is a single polypeptide chain of 190 residues, with two sets of haem-attachment cysteine residues at positions 14/17 and 119/122. Proteins with similar sequences are also present in denitrifying pseudomonads. There is similarity in sequence between the two halves of the cytochrome c4 molecule, and each half also shows similarity to the sequences of certain monohaem cytochromes c isolated from organisms that are not obviously closely related to A. vinelandii. Detailed evidence for the amino acid sequence of the protein has been deposited as Supplementary Publication SUP 50125 (17 pages) at the British Library Lending Division, Boston Spa, West Yorkshire LS23 7BQ, U.K., from whom copies are available on prepayment.
Amino Acid Sequence↗
Proliferative response of human venous endothelial cells to medium conditioned by human tumour cells.
Serum-free medium conditioned by the prior cultivation of cells of the IPT line (derived from a poorly differentiated carcinoma of the lung) contained material of a high MW which stimulated proliferation in cultures of endothelial cells from human umbilical vein. A response was shown by cells seeded on plastic, gelatin or collagen of type I or type IV, at densities of 25 to 200/mm2, and in media with serum concentrations ranging from 0.5 to 20% v/v. Cells plated on biological substrata showed a greater response than those on plastic.
Angiogenesis Inducing Agents↗
Autoradiographic localization of peripheral benzodiazepine binding sites in the cat brain with [3H]PK 11195.
"Peripheral type" benzodiazepine binding sites were labelled in cat brain membranes by using [3H]PK 11195. This ligand binds to the "peripheral type" binding sites in a reversible, specific and saturable manner. Cat brain binding sites density (congruent to 6 pmol/mg prot.) was higher than in the rat. Pharmacological specificity was demonstrated by the potency order of displacing agents: PK 11195 greater than RO5-4864 greater than dipyridamole greater than diazepam greater than clonazepam. A similar characterization was performed in slide mounted brain sections where [3H]PK 11195 also labelled the "peripheral type" benzodiazepine binding sites. The high percentage of specific binding (80%) at 1 nM of [3H]PK 11195 made possible the autoradiographic studies on binding sites distribution. These sites were heterogeneously distributed in the grey matter and absent in white matter. Visual, auditory and other specific sensory relay stations were highly labelled. The blood pressure regulating nuclei, the vestibulo-cerebellar and the extrapyramidal motor system also presented a very high binding density. As previously described in the rat brain, choroid plexus was also strongly labelled by [3H]PK 11195 in the cat.
Animals↗
Assessment of level of consciousness following severe neurological insult. A comparison of the psychometric qualities of the Glasgow Coma Scale and the Comprehensive Level of Consciousness Scale.
An alternative method of coma assessment is presented and compared with the Glasgow Coma Scale. The merits of the Comprehensive Level of Consciousness Scale as a research tool are presented. An analysis of 101 consecutive consciousness-impaired patients with their short-term outcome is presented.
Adolescent↗
Pharmacological evidence that PK 8165 behaves as a partial agonist of brain type benzodiazepine receptors.
PK 8165, a new quinoline derivative, has a good affinity for brain type benzodiazepine binding sites and an anticonflict activity in the Vogel Test. However, contrarily to classical benzodiazepines (BZ) this compound is devoid of anticonvulsant and sedative properties. As biochemical studies suggested that PK 8165 is a partial agonist for BZ receptors, its interactions with convulsant, sedative and muscle relaxant properties of diazepam (DZ) were investigated. PK 8165 potentiates (12.5 to 50 mg/kg i.p.) the antagonistic effect of DZ on M.E.S.-induced seizures and footshock-induced fighting in mice. Moreover, PK 8165 potentiates in the same dose range the muscle relaxant and hypnotic effects of DZ in mice. These potentiations are specific since PK 8165 does not interfere with phenobarbital and mebubarbital effects in M.E.S. and righting reflex in mice. Also, PK 8165's anticonflict activity (punished drinking in thirsty rats) is antagonized by RO15-1788, a specific antagonist of centrally active BZ.
Aggression↗
Occurrence of ixodid ticks--the main vectors of tick-borne encephalitis virus in urbanized territory.
The influence of urbanization on ticks I. ricinus and I. persulcatus--the main vectors of tick-borne encephalitis virus is discussed on the basis of concrete examples. It has been revealed that under favourable conditions the populations of these tick species can exist for a long time not only in towns and new housing estates, but in the old residential districts as well. The necessity of studying the ecology of urban populations of ixodid ticks is pointed out.
Animals↗
Human lung tumour cell line adapted to grow in serum-free medium secretes angiogenesis factor.
A human lung tumour cell line has been grown in serum-free medium for 12 months and during this period cells were subcultured every 4 days. The culture medium contained an angiogenesis factor which has been purified and shown to be similar to that isolated from other sources including solid tumours. This is the first report that demonstrates de novo synthesis and secretion of angiogenesis factor by a cell line adapted to grow in a serum-free medium.
Angiogenesis Inducing Agents↗
Therapists' and chronic pain patients' perceptions of treatment outcome.
Pain is a complex phenomenon which is influenced by multiple factors; likewise, assessment of chronic pain patients' response to treatment is influenced by many variables. A physician, psychologist, physical therapist, and occupational therapist rated the extent of recovery of 40 chronic pain patients who had spent 4 to 6 weeks in an inpatient chronic pain treatment program. Each patient also rated his/her own degree of improvement. In addition, therapists and patients reported which factors were the primary determinants of their outcome ratings. Although therapists rated the patients as significantly more improved than the patients rated themselves, there was still a high degree of similarity between therapists' and patients' view of recovery. Therapists and patients were in high agreement concerning which patients were classified as treatment successes or failures. Furthermore, activity level and ability to cope with pain were frequently endorsed by therapists and patients as important determinants of recovery rating. Contrary to a previous report, the results of this study suggest that pain patients are not necessarily poor judges of (their own) treatment results. Perhaps more importantly, this study supports the use of a broad-based multidimensional approach to assessing treatment outcome for chronic pain patients.
Adult↗
Laelapidae (Acarina) of some small mammals from Toro game reserve, Uganda.
Laelapid mites of some small mammals from the Toro Game Reserve in Western Uganda were studied. The following species were determined: Laelaps (Echinolaelaps) muricola Trägãrdh, L. (E.) giganteus Berlese, L. (laelaps) grenieri Taufflieb, L. (L.) kampalensis Taufflieb, L. (L.) liberiensis Hirst, Androlaelaps callosus (Berlese) and A. zulu (Berlese). A female and a male of a new species Androlaelaps verneri sp. N. and up to now unknown males of A. callosus and L. kampalensis are described. All species found are briefly discussed.
Animals↗
[Humeral fracture caused by arm wrestling].
Humeral shaft fractures may occur as a result of arm wrestling ("Indian wrestling," "iron arm"), a contest in which the antagonists sit face-to-face, grip hands with their elbows on a table, and try to force the opponent's arm back. A case of this type is reported.
Adult↗
Amino acid sequences of bacterial cytochromes c' and c-556.
The cytochrome c' are electron transport proteins widely distributed in photosynthetic and aerobic bacteria. We report the amino acid sequences of the proteins from 12 different bacterial species, and we show by sequences that the cytochromes c-556 from 2 different bacteria are structurally related to the cytochromes c'. Unlike the mitochondrial cytochromes c, the heme binding site in the cytochromes c' and c-556 is near the COOH terminus. The cytochromes c-556 probably have a methionine sixth heme ligand located near the NH2 terminus, whereas the cytochromes c' may be pentacoordinate. Quantitative comparison of cytochrome c' and c-556 sequences indicates a relatively low 28% average identity.
Amino Acid Sequence↗
[Total hip replacement in a youth with chondroblastoma].
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Adolescent↗
Increased infectivity of oncogenic herpes viruses of primates with tumor promoter 12-O-tetradecanoylphorbol-13-acetate.
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Animals↗
[Occurrence of ticks and chigger mites in urban areas (author's transl)].
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Animals↗
A comparison of developmental dynamics of Dermacentor reticulatus (Fabr.) of different geographic origins and their affection by different microclimate.
Developmental dynamics of D. reticulatus ticks of different geographic origins (NE Poland and SW Slovakia) were investigated and compared. A long-term field experiment was conducted in South Moravia in the zone of thermophilic oak forest. Ticks were studied in two different biotopes: in an open grassy area and in deciduous forest. Differences between the tick populations collected in Poland and Slovakia were observed in the duration of developmental cycle and in the outcome of metamorphosis, depending on biotope. The tick development in the open grassy area was more rapid, but with greater losses. The total production of adults was higher in the population originating from Slovakia.
Animals↗
Development of the tick Ixodes laguri Ol. in the nests of the European suslik Citellus citellus (L.).
In field and laboratory conditions new data were obtained concerning the life cycle of the nidicolous tick Ixodes laguri. The development of this tick was studied in experimental nests of the European suslik and a two-year cycle of I. laguri was demonstrated. However, the materials obtained indicate that a longer cycle may be anticipated.
Animals↗
Note on some diptera (Tabanidae, Glossinidae, Muscidae and related families) at the peak of dry season in Toro Game Reserve, Uganda.
The authors studied the occurrence of haematophagous and non-haematophagous flies in three different collecting sites in the Toro Game Reserve in western Uganda, at the dry season peak (January, February), using canopy trap and baited traps. Collected were 6 species of Tabanidae, 1 species of Glossinidae, 24 species of Muscidae, 3 species of Calliphoridae, 4 species of Sarcophagidae and 3 species of other families.
Animals↗